634 results match your criteria: "Unidad de Hospitalización de Salud Mental[Affiliation]"

Background: Some of the key challenges during the breast cancer diagnosis process include a lack of information and negative psychological consequences, such as distress and anxiety about the process. Implementing a psychoeducational program during the diagnosis process may enhance the well-being of women. "" is an Internet-Based Psychoeducational Program (IBPP) that comprises three interventions: A ("Improving Your Health Habits and Self-Care"), B ("Waiting for the Result of Your Biopsy"), and C ("Supporting You After Your Breast Cancer Diagnosis").

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Unlabelled: Individuals with psychiatric disabilities face significant challenges in achieving workforce inclusion, presenting a critical public health issue. The enactment of Law 21.015 on this matter offers an opportunity for improvement.

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Background: Hospital readmissions of users with personality disorders are frequent and represent a high personal and economic cost for health systems. This study aimed to identify risk factors associated with readmission in this population, examining sociodemographic and clinical variables.

Methods: A retrospective observational study was conducted, using electronic records.

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Tc-DTPA-Collagen Radiotracer for the Noninvasive Detection of Infective Endocarditis.

ACS Infect Dis

January 2025

Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain.

Infective endocarditis (IE) represents a significant concern among hospital-acquired infections, frequently caused by the Gram-positive bacterium . Nuclear imaging is emerging as a noninvasive and precise diagnostic tool. However, the gold standard radiotracer [F]-FDG cannot distinguish between infection and inflammation, resulting in false positives.

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Background: Alterations of dopamine (DA) transmission in the brain reward system can be associated with an addictive-like state defined as food addiction (FA), common in obese individuals. Subjects affected by FA experience negative feelings when abstinent from their preferred diet and may develop mood disorders, including depression, sustained by alterations in brain DA pathways.

Objective: This study aims to investigate the impact of long-term abstinence from a palatable diet on depressive-like behavior in rats, exploring neurochemical alterations in monoamine and endocannabinoid signaling in DA-enriched brain regions, including ventral tegmental area, dorsolateral striatum, substantia nigra and medial prefrontal cortex.

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Corrigendum to "Lung function decline in people with serious mental illness: A call to action" [European Neuropsychopharmacology (2024) 41-46/ ENP-24-342].

Eur Neuropsychopharmacol

January 2025

Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal, 14004 Córdoba, Spain; Reina Sofia University Hospital, Avenida Menéndez Pidal 7, 14004 Córdoba, Spain; University of Cordoba, Departament of Morphological and Sociosanitary Science, Córdoba, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

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Disordered eating in anorexia nervosa: give me heat, not just food.

Front Public Health

November 2024

Venres Clínicos Unit, College of Psychology, University of Santiago de Compostela, Santiago de Compostela, Spain.

The recommendation to apply external heat to patients with anorexia nervosa (AN) was first documented by William Gull in 1874. Gull encountered this practice during his tenure as a consultant physician, responsible for issuing medical certifications for wealthy clients seeking admission to Ticehurst Asylum, one of the most successful and reputable private asylums in England. Gull attributed the origins of this practice to the studies by Charles Chossat (1796-1875), a physiologist, physician, and politician from Geneva, who discovered the therapeutic effects of heat on starved animals by chance.

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Evaluation of the neuroprotective effect of antipsychotics by serum quantification of protein S100B.

Farm Hosp

November 2024

Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, España; Facultad de Enfermería y Fisioterapia, Universidad de Cádiz, Cádiz, España.

Objective: This research delves into the intricate interplay between antipsychotic medications and neuroprotection focusing on the S100B protein, a central player in the regulation of neuroapoptotic activity.

Method: Blood samples were collected to assess serum S100B protein levels using an immunoassay of immunoelectrochemiluminescence. The first two samples were collected with a 3-month interval between each, and the third sample was obtained 6 months after the previous one.

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Reducing self-stigma in psychosis: A systematic review and meta-analysis of psychological interventions.

Psychiatry Res

December 2024

Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Grup MERITT, Fundació Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain; Fundació de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain.

The burden of self-stigma in psychosis has been widely studied, leading to the development and implementation of self-stigma reduction programmes to ameliorate its impact. In order to successfully improve self-stigma in psychosis, we must evaluate the effect of available interventions to help clinicians select the most appropriate approach for their patients. This systematic review and meta-analysis aimed to evaluate the effect of self-stigma reduction interventions in people with psychosis while considering the interventions' characteristics as an important moderator of their effect.

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Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose transporter, i.e.

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ANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.

Int J Mol Sci

October 2024

Laboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.

Article Synopsis
  • The IA polymorphism is linked to both the Ankyrin Repeat and Kinase Domain-containing I gene (ANKK1) and the D2 dopamine receptor gene, posing challenges in understanding its role in addictions and psychiatric disorders due to unclear ANKK1 functions.
  • Research using SH-SY5Y neuroblastoma models shows that ANKK1 interacts with FARP1, a synapse protein, contributing to neuronal maturation and the activation of the Wnt/PCP pathway while promoting neuritogenesis.
  • Interactions between ANKK1 and WGEF are crucial for regulating RhoGTPases during neuronal differentiation, indicating that ANKK1 may play a significant role in organizing the brain's structural response related to IA-associated
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Article Synopsis
  • A large-scale, cross-national study examined the impact of removing the "excessiveness" requirement for diagnosing generalized anxiety disorder (GAD) among individuals living in challenging circumstances.
  • Data from over 133,000 adults across various income countries revealed that eliminating this criterion raises the global prevalence of GAD from 2.6% to 4.0%, especially in low- and middle-income countries.
  • Non-excessive worriers, while less severe, exhibit similar socio-demographic traits and impairment levels as excessive worriers, indicating they are significant cases deserving diagnosis and treatment.
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Lung function decline in people with serious mental illness: A call to action.

Eur Neuropsychopharmacol

December 2024

Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Avenida Menéndez Pidal, 14004 Córdoba, Spain; Reina Sofia University Hospital, Avenida Menéndez Pidal 7, 14004 Córdoba, Spain; University of Cordoba, Departament of Morphological and Sociosanitary Science, Córdoba, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

This prospective observational study aimed to evaluate the rate of change in forced expiratory volume in the first second (FEV1) and to explore the factors associated with changes in FEV1 in people with serious mental illness (SMI). Sixty subjects diagnosed with schizophrenia or bipolar disorder who were smokers and without history of respiratory illness agreed to participate. The mean (range) follow-up period was 3.

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Article Synopsis
  • Adolescent stress and alcohol exposure can lead to increased risk of mental disorders in adulthood, with notable differences between males and females in their responses.
  • The study involved male and female rats subjected to stress and alcohol to evaluate hormonal and genetic changes, revealing sex-specific responses in hormones like ACTH and CORT, and gene expressions related to stress response.
  • Key findings included that stressed males had lower alcohol levels, females had heightened ACTH under stress, and distinct patterns in hormonal changes and gene expression between sexes were observed, indicating the complexity of their interactions.
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Circulating Cell-Free Mitochondrial DNA in Plasma of Individuals with Schizophrenia and Cognitive Deficit in Mexican Population.

Neuropsychiatr Dis Treat

September 2024

Laboratorio de Genómica de las Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México, México.

Purpose: Cognitive domains are affected in patients with schizophrenia. Mitochondrial dysfunction has been proposed as a possible origin of these symptoms. Cell-free mitochondrial DNA (cf-mtDNA) is an indicator of cellular stress, and it can be identified in individuals with age-associated disorders, this study aimed to explore the presence of cf-mtDNA in plasma of schizophrenia patients and its association with cognitive deficit.

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Article Synopsis
  • Health care providers are experiencing increased levels of stress, anxiety, and depression post-COVID-19, necessitating ongoing mental health support and monitoring.
  • The study examined job stressors among Spanish health care providers, finding that physicians faced worse stress outcomes compared to nurses, particularly related to workload and social interactions.
  • Key predictors of mental health issues differ between physicians and nurses, with physicians affected by inequity in social interactions and job satisfaction, while nurses are impacted by role ambiguity and interpersonal conflicts.
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Pathways to strengthen the climate resilience of health systems in the Peruvian Amazon by working with Indigenous leaders, communities and health officers.

BMJ Glob Health

September 2024

Unidad de Ciudadanía Intercultural y Salud Indígena (UCISI), Facultad de Salud Pública y Administración, Universidad Peruana Cayetano Heredia, San Martín de Porres, Peru

Background: Indigenous knowledge and responses were implemented during the COVID-19 pandemic to protect health, showcasing how Indigenous communities participation in health systems could be a pathway to increase resilience to emergent hazards like climate change. This study aimed to inform efforts to enhance climate change resilience in a health context by: (1) examining if and how adaptation to climate change is taking place within health systems in the Peruvian Amazon, (2) understanding how Indigenous communities and leaders' responses to climatic hazards are being articulated within the official health system and (3) to provide recommendations to increase the climate change resilience of Amazon health systems.

Methods: This study was conducted among two Peruvian Amazon healthcare networks in Junin and Loreto regions.

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Design and validation of novel flow cytometry panels to analyze a comprehensive range of peripheral immune cells in mice.

Front Immunol

August 2024

Unidad de Medicina y Cirugía Experimental, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

The use of flow cytometry in mice is constrained by several factors, including the limited availability of mouse-specific antibodies and the need to work with small volumes of peripheral blood. This is particularly challenging for longitudinal studies, as serial blood samples should not exceed 10% of the total blood volume in mice. To address this, we have developed two novel flow cytometry panels designed to extensively analyze immune cell populations in mice during longitudinal studies, using only 50 µL of peripheral blood per panel.

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To explore the experiences and preferences of patients and healthcare professionals regarding the development of an app to provide psychological intervention to improve emotion regulation in the context of bariatric surgery (BS). Sixteen people (6 patients who underwent BS and 10 professionals) participated in two separate focus group sessions. We performed a content analysis of transcribed focus group discussions to extract and organize categories, subcategories and areas.

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The management of schizophrenia necessitates a comprehensive treatment paradigm that considers individual patient nuances and the efficacy of lurasidone in addressing schizophrenia symptoms, particularly at elevated dosages. Numerous randomized trials have affirmed the efficacy of lurasidone across various dimensions of schizophrenia, demonstrating marked enhancements in positive, negative and cognitive symptoms compared to a placebo. In addition, lurasidone exhibits potential in ameliorating agitation amongst acutely ill patients, showcasing greater efficacy at higher doses.

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This real-world study aimed to describe patient and clinical characteristics, treatment patterns and outcomes for patients with HR+/HER2- metastatic breast cancer receiving abemaciclib in France, Italy and Spain. A multicenter chart review was conducted for adult females with HR+/HER2- advanced/metastatic breast cancer who received abemaciclib in routine care. Real-world progression-free survival (rwPFS) was estimated via Kaplan-Meier curves.

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Cocoa is widely known for its health benefits, but its neurocognitive impact remains underexplored. This preclinical study aimed to investigate the effects of cocoa and cocoa polyphenols on hippocampal neuroplasticity, cognitive function and emotional behavior. Seventy young-adult C57BL/6JRj male and female mice were fed either a standard diet (CTR) or a diet enriched with 10% high-phenolic content cocoa (HPC) or low-phenolic content cocoa (LPC) for at least four weeks.

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Vulvovaginal candidiasis (VVC) is characterized as a very common fungal infection that significantly affects women's health worldwide. Essential oils (EOs) are currently being evaluated as an alternative therapy. The development of efficient techniques such as micro- or nanoencapsulation for protecting and controlling release is essential to overcome the limitations of EO applications.

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