Cross-Sectional Survey among General Population Regarding Knowledge and Attitude toward Antibiotic Usage in Western Saudi Arabia.

Background: Antibiotic resistance is a threatening issue to human wellbeing and an obstacle in the treatment process of many life-threating illnesses. This study aims to assess the knowledge and attitudes toward antibiotic usage among the general population in Jeddah, Saudi Arabia.

Methods: A self-administered cross-sectional survey of 460 participants was distributed among the general population in Jeddah in the form of a validated questionnaire.

p53 Rather Than β-Catenin Mediated the Combined Hypoglycemic Effect of () and Roscoe in the Streptozotocin-Induced Diabetic Model.

The antioxidant, hypoglycemic, and insulin-enhancing effects of ginger and cinnamon were previously confirmed in experimental and human studies, while the combined effect of ginger and cinnamon was not thoroughly investigated until now. This study was designed to assess the antidiabetic effect of combined administration of ginger ( Roscoe) and cinnamon ( L.) in streptozotocin (STZ)-induced diabetic rats compared to metformin and to explain the mechanism behind this effect.

Epidemiology of depression and anxiety among undergraduate students.

Aims: Depression and anxiety are the most common and prevalent mental health issues among undergraduate students. This study aimed to investigate the prevalence of anxiety and depression, their associated predictors, and to assess knowledge and use of antidepressant medications among university students in Jordan.

Methods: A cross-sectional survey-based study was conducted in Jordan among undergraduate students from all levels of study.

Safety and discontinuation rate of immune checkpoint inhibitors used in patients with solid and hematological malignancies. A population based retrospective analysis.

Background: The discovery of immune checkpoint inhibitors caused a paradigm shift in cancer treatment and led to a major improvement in clinical outcomes. However, they may induce inflammatory side effects that are known as immune-related adverse effect (iRAE). This study aimed to assess the safety profile and discontinuation rate of immune checkpoint inhibitors in cancer patients.

Dexamethasone and diclofenac intramuscular mixture injection and risk of death: A case series study.

Diclofenac and dexamethasone injection mixture could be associated with fatal cardiovascular events, further studies are warrantied to explore the safety of this injection mixture and explore the genetic role of it.

Clinical impact of the first pass effect on clinical outcomes in patients with near or complete recanalization during mechanical thrombectomy for large vessel ischemic stroke.

Background And Purpose: The first pass effect has been reported as a mechanical thrombectomy (MT) success metric in patients with large vessel occlusive stroke. We aimed to compare the clinical and neuroimagign outcomes of patients who had favorable recanalization (mTICI 2c or mTICI 3) achieved in one pass versus those requiring multiple passes.

Methods: In this "real-world" multicenter study, patients with mTICI 2c or 3 recanalization were identified from three prospectively collected stroke databases from January 2016 to December 2019.

Knowledge and awareness of the general population and healthcare providers about retinoblastoma: It is time to know the glow.

Retinoblastoma is the most frequent primary intraocular tumour in childhood. Early detection of retinoblastoma is the key to successful management with a higher chance of survival. This study aims to assess the knowledge of the general population and healthcare providers about retinoblastoma in term of presentation, risk factors, timing for diagnosis, and complications.

Cybercrime Awareness among Saudi Nationals: Dataset.

The supplementary dataset presented in this paper was used to measure the level of cybersecurity awareness of cybercrime in Saudi Arabia, presented in detail in [1]. The data were collected during the period of August to October of 2019. The dissemination process took place via an online questionnaire.

Multidrug-resistant in Raw Milk: Molecular Characterization and the potential impact of camel's Urine as an Antibacterial Agent.

Raw milk is one of the most important vehicles for transmitting various pathogens, especially (). Multidrug-resistant pathogens are highly prevalent among mastitic cows in various dairy farms worldwide. Therefore, our current study is based on the identification of from mastitic cow's milk and their resistance to various antibacterial agents.

The COVID-19 pandemic: prediction study based on machine learning models.

COVID-19 was first discovered in Wuhan, China in December 2019. It is one of the worst pandemics in human history. Recent studies reported that COVID-19 is transmitted among humans by droplet infection or direct contact.

The Pattern of Allopurinol Prescription Among Chronic Kidney Disease Patients in a Tertiary Care Centre: A Single-Centre Experience.

Context: Hyperuricemia is prevalent in patients with chronic kidney disease (CKD). Although it is associated with CKD incidence and progression, treating asymptomatic hyperuricemia with uric acid-lowering agents is still debatable.

Aim Of Work: determine the rate of non-classical prescription of allopurinol in CKD patients.

The willingness of the Saudi Arabian population to participate in the COVID-19 vaccine trial: A case-control study.

Objectives: This study examines the Saudi Arabian population's willingness to participate in clinical trials for the coronavirus disease 2019 (COVID-19) vaccine, comparing recovered cases' willingness with that of healthy volunteers.

Methods: A case-control study was conducted on the Saudi Arabian population during September 2020. The data were collected from recovered COVID-19 participants as the case group, and healthy volunteers as the control group.

Effect of high-power Nd:YAG laser on the growth of and : an experimental study.

[Purpose] The aim of this study was to evaluate the effect of high-power Nd:YAG laser on and bacterial growth. [Materials and Methods] Seven samples of and seven samples of were prepared in the microbiology lab, one used as a control sample and the remaining six samples used as experimental samples, which were irradiated by a high-power laser (LASERSIX ME, 15W) with a total dose of 500 and 700 J. The primary measure was the semi-qualitative assessment of turbidity and bacterial count; the turbidity was assessed 24 h after laser application.

Impact of COVID-19 on the rate of stroke cases at a tertiary hospital in Makkah, Saudi Arabia.

Objectives: To assess and quantify the impact COVID-19 has had thus far on ischemic stroke admission rate and severity (National Institutes of Health Stroke Scale (NIHSS) score) at a single tertiary center in Makkah, Saudi Arabia.

Methods: This is a retrospective analysis performed on admitted cases with definitive final diagnoses of transient ischemic attack (TIA) and ischemic stroke at King Abdullah Medical City in Makkah between January 1, 2020 and July 2020.

Results: Sixty-nine patients were included in our study, 41 of whom presented at our facility before the pandemic and 29 during the pandemic.

Combination of coumarin and doxorubicin induces drug-resistant acute myeloid leukemia cell death.

Background: Chemotherapy remains to be the method of choice used by clinicians to treat acute myeloid leukemia (AML) patients. However, the most common problem usually faced in the course of treatment is multidrug resistance (MDR). Nowadays, combination therapy involving natural products as adjuvant therapy to chemotherapy and radiotherapy has been used for many of health problems.

Emergency oncology admissions during COVID-19 pandemic: a major institution experience from Saudi Arabia.

Background: The WHO has declared the coronavirus disease 2019 (COVID-19) pandemic in March 2020. Cancer patients are considered a highly susceptible group. The effect of this pandemic on cancer mortality is still unknown.

A National Survey of Self-Prescription of Beta-Blockers and Their Relation to Undiscovered Anxiety Among Medical and Pharmacological Students in Saudi Arabia.

Background: The development of beta-blocker (BB) medications is considered one of the most critical milestones of drug research. Several trials showed possible anti-anxiety effects of BBs. Our primary goal is to investigate the prevalence of anxiety disorder and the use of BBs as anxiolytic without medical prescription among medical and pharmacological students in Saudi Arabia.

Stabilization of β-Galactosidase on Modified Gold Nanoparticles: A Preliminary Biochemical Study to Obtain Lactose-Free Dairy Products for Lactose-Intolerant Individuals.

The unique chemical, optical, and electrical characteristics of nanoparticles make their utilization highly successful in every field of biological sciences as compared to their bulk counterpart. These properties arise as a result of their miniature size, which provides them an excellent surface area-to-volume ratio, inner structure, and shape, and hence increases their surface characteristics. Therefore, this study was undertaken to engineer gold nanoparticles (AuNPs) for improving their catalytic activity and stability in biotechnological processes.

The role of exercise therapy in managing post-radiotherapy trismus in head and neck cancer.

Trismus is a post-radiotherapy complication that affects survivors of head and neck cancers. It is described as the reduction of mouth opening to less than 35 mm. The condition is a progressive process; hence early intervention is crucial to prevent further damage and weakness to the elevator muscles of the mandible.

The pH-Induced Specific Area Changes of Unsaturated Lipids Deposited onto a Bubble Interface.

In this work, we used an original experimental setup to examine the behavior of insoluble monolayers made with pH-sensitive lipids. Two kinds of unsaturated lipids were chosen: a cationic one (lipid ) bearing an ammonium headgroup and an anionic one (lipid ) terminated with an acidic phenol group. The lipids were deposited onto an air bubble interface maintained in an aqueous phase and, after stabilization, were subjected to a series of compressions performed at different pH values.

Cost considerations of dermatological care in Jordan: a cross-sectional study.

Background: Physicians play a key role in improving patient adherence, specifically in dermatological care. Expensive medications are associated with poor patient adherence and worsening clinical outcomes. This study aims to explore the cost estimation interest of patients with dermatological conditions, the influence of the cost on their drug use behavior, and cost communication practices by dermatologists.

Measuring the level of cyber-security awareness for cybercrime in Saudi Arabia.

The revolution in the Information Technology (IT) field has led to a significant increase in the number of people connected to and utilizing the Internet. However, it has also introduced severe security risks: valuable information such as passwords, financial accounts, and other confidential data are considered attractive targets for attackers. Cyber-attacks against this infrastructure can not only lead to data leakage but can also have significant financial implications and even lead to loss of life.

Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction for which there is an unmet need for better treatment options. Although oxidative stress is a common feature of neurodegenerative diseases, notably PD, there is currently no efficient therapeutic strategy able to tackle this multi-target pathophysiological process. Based on our previous observations of the potent antioxidant and neuroprotective activity of SELENOT, a vital thioredoxin-like selenoprotein, we designed the small peptide PSELT from its redox active site to evaluate its antioxidant properties in vivo, and its potential polyfunctional activity in PD models.

Robot-Assisted Radical Prostatectomy in Low-Volume Regions: Should It Be Abandoned or Adopted? A Multi-Institutional Outcome Study.

To present multinational experience in robot-assisted radical prostatectomy (RARP) by fellowship-trained expertise in low-volume regions in Gulf Cooperation Council (GCC) countries and to compare the current results with global outcomes reported in recent meta-analyses. A retrospective review of prospectively collected data was performed for patients undergoing RARP for localized prostate cancer (PCa). Three fellowship-trained surgeons at four academic and referral centers in Saudi Arabia and Kuwait performed all procedures between February 2014 and December 2019.

The Effectiveness of the SKINCARE Bundle in Preventing Medical-Device Related Pressure Injuries in Critical Care Units: A Clinical Trial.

Objective: To examine the impact of a medical device-related pressure injury (MDRPI) prevention bundle/mnemonic on the incidence of acquired MDRPIs in critically ill patients.

Methods: This study used a prospective, single-arm, open-label clinical design and was carried out from January to April 2020 in CCUs in a Saudi Arabian tertiary hospital. All participants received the SKINCARE bundle intervention, which is based on the best available evidence for MDRPI prevention in CCUs.