Prevalence and control of hypertension in COVID-19 positive cases.

Background: The coronavirus disease (COVID-19) is an infectious disease caused by the newly discovered SARS-CoV-2 virus. Patients diagnosed with COVID-19 experience several complications including hypertension or elevated blood pressure which is a serious medical condition that significantly increases the risks of heart, brain, and kidney diseases.

Objectives: To assess the prevalence and control of hypertension in COVID-19 patients.

Bibliometric analysis: A few suggestions (Part Two).

This manuscript serves as a follow-up to our previous work, "Bibliometric Analysis: A Few Suggestions," where we highlighted key aspects of bibliometric research and offered recommendations for improving its rigor. In this draft, we expand on those ideas and provide additional suggestions aimed at enhancing the depth and scope of bibliometric analysis. By analyzing 36 randomly selected bibliometric studies, we identified common practices and gaps in the field, which informed the inclusion of new recommendations not covered in our earlier paper.

The tumor distance to the main hepatic vessels is a predictor of recurrence-free survival and overall survival in hepatocellular cancer.

Introduction: The impact of the distance of the tumor from the main hepatic vessels (DTV), such as the Glissonean pedicle or hepatic veins, on oncological outcomes for Hepatocellular carcinoma (HCC) patients is relatively understudied. Therefore, the objective of this study was to explore the correlation between DTV and survival in patients with HCC after curative hepatic resection.

Methods: Consecutive patients who underwent curative-intent liver surgery for HCC between April 2018 and May 2023 were identified from a prospective database.

Assessment of lipid peroxidation and total antioxidant capacity in patients with breast cancer.

Aim: Breast cancer (BC), a disease in which abnormal breast cells grow out of control and form tumors, is a prevalent life-threatening disease worldwide. Oxidative stress has been implicated in the development and progression of various cancers, including BC. Assessing lipid peroxidation and overall antioxidant status in BC offers valuable information on disease progression, patient prognosis, and the effectiveness of therapeutic options.

Regulation of INPP5E in Ciliogenesis, Development, and Disease.

Inositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune regulation, hemopoietic cell dynamics, and macrophage proliferation, differentiation, and phagocytosis. Mutations in cause Joubert and Meckel-Gruber syndromes in humans; these are characterized by brain malformations, microphthalmia, situs inversus, skeletal abnormalities, and polydactyly. Recent studies have demonstrated the key role of INPP5E in governing intracellular processes like endocytosis, exocytosis, vesicular trafficking, and membrane dynamics.

Fracture resistance and behavior of endodontically treated maxillary premolars with varying ferrule heights and post numbers: A laboratory study.

Purpose: To investigate how varying ferrule heights and the number of glass fiber posts affect fracture resistance and behavior of endodontically treated maxillary first premolars with substantial loss of tooth structure.

Materials And Methods: Twenty-four extracted endodontically treated human maxillary first premolars were divided into three groups (n = 8) based on ferrule height and post number. The groups were as follows: premolars of 2 mm ferrule height that were restored with single posts (control group), premolars of 0.

Quantum-resilient software security: A fuzzy AHP-based assessment framework in the era of quantum computing.

The introduction of quantum computing has transformed the setting of information technology, bringing both unprecedented opportunities and significant challenges. As quantum technologies continue to evolve, addressing their implications for software security has become an essential area of research. This paradigm change provides an unprecedented chance to strengthen software security from the start, presenting a plethora of novel alternatives.

Synergistic design of a graphene oxide-mediated polyaniline/α-FeO ternary heterostructure: advancing photocatalytic degradation and adsorption efficiency.

With the growing threat of organic pollutants in water bodies, there is an urgent need for sustainable and efficient water decontamination methods. This research focused on synthesizing a novel Z-scheme ternary heterostructure composed of graphene oxide (GO)-mediated polyaniline (PANI) with α-FeO and investigated its potential in brilliant green (BrG) and ciprofloxacin (CIP) degradation tests under visible light. The ternary composite demonstrated exceptional photocatalytic activity, with the optimized 10%PANI/GO/α-FeO (10PGF) photocatalyst achieving 99.

Genome-Wide Association Mapping of Macronutrient Mineral Accumulation in Wheat ( L.) Grain.

The focus on increasing wheat ( L.) grain yield at the expense of grain quality and nutrient accumulation can lead to shortages in macronutrient minerals, which are dangerous for human health. This is important, especially in nations where bread wheat is used in most daily dietary regimens.

The Perils of Methanol Exposure: Insights into Toxicity and Clinical Management.

Methanol is a widely used industrial and household alcohol that poses significant health risks upon exposure. Despite its extensive use, methanol poisoning remains a critical public health concern globally, often resulting from accidental or intentional ingestion and outbreaks linked to contaminated beverages. Methanol toxicity stems from its metabolic conversion to formaldehyde and formic acid, leading to severe metabolic acidosis and multiorgan damage, including profound CNS effects and visual impairments.

Repurposing Dapagliflozin for Mitigation of the Kidney Injury Triggered by Cadmium in Rats: Role of Autophagy, Apoptosis, and the SIRT1/Nrf2/HO-1 Pathway.

The antioxidant/antiapoptotic features of dapagliflozin (DPG) have mediated its beneficial actions against several experimental models. However, no studies have been conducted to determine whether DPG mitigates the renal injury triggered by cadmium (Cd). Herein, DPG was studied for its potential to attenuate kidney damage in Cd-intoxicated rats, as well as to unravel the mechanisms involving oxidative events, autophagy, and apoptosis.

Phytochemical Analysis and Multifaceted Biomedical Activities of Extract as Natural Product-Based Therapies.

This study examined the phytochemical profile and biomedical activities of , a halophytic and drought-resistant shrub. HPLC analysis showed gallic acid (1905.1 μg/g), catechin (1984.

Unraveling Genetic Variation and Inheritance Patterns in Newly Developed Maize Hybrids for Improving Late Wilt Disease Resistance and Agronomic Performance Under Artificial Inoculation Conditions.

Late wilt disease caused by the fungal pathogen represents a major threat to maize cultivation in the Mediterranean region. Developing resistant hybrids and high-yielding offers a cost-effective and environmentally sustainable solution to mitigate yield losses. Therefore, this study evaluated genetic variation, combining abilities, and inheritance patterns in newly developed twenty-seven maize hybrids for grain yield and resistance to late wilt disease under artificial inoculation across two growing seasons.

Vitiligo detection capabilities of 1D photonic crystal biosensing design.

This theoretical work focuses on the application of Tamm resonance-based biosensing using a one-dimensional photonic crystal for detecting skin vitiligo, a condition caused by the loss of pigment in the body. This biosensor utilizes the interaction of light with the photonic structure to identify the specific biomarkers associated with vitiligo. The proposed structure is composed of prism/Ag/skin-sample/(GaP/PS)/glass.

Synthesis of Schiff bases based on Chitosan, thermal stability and evaluation of antimicrobial and antitumor activities.

A Schiff base of Chitosan was prepared by condensing of the Chitosan (CS) with six aromatic aldehydes and confirmed by FT-IR, NMR, XRD, TGA, and DSC. XRD results showed the disappeared of peaks at 2θ = 10° for CS and appeared one peaks at around 2θ of 23° for Schiff bases, while TGA was demonstrated that the thermal stability of CS has improved after the modification with the corresponding aldehyde. Also, DSC shows endothermal peak of CS at 100 °C due to the loss of water and second thermal event related to the decomposition of amine units with an exothermic peak at 295 °C, while Schiff bases shows endothermal peak around 70-95 °C which is related to the loss of water for all samples and the second exothermic peak around 260-280 °C is related to the decomposition of the amine group in the polymer units.

Formulation and characterization of inhalable dasatinib-nanoemulsion as a treatment potential against A549 and Calu-3 lung cancer cells.

Objective: Dasatinib (DTB) is a second-generation tyrosine kinase inhibitor that was found it could help with lung cancer treatment. However, DTB has low aqueous solubility and poor bioavailability due to its incomplete absorption and high first-pass effect. The objective of this study was to improve DTB's solubility, delivery, and efficacy as a potential lung cancer treatment by developing an inhalable DTB-nanoemulsion (DNE) formulation.

Surgical vs. Conservative Treatment of Distal Radius Fractures in the Elderly: A Systematic Review and Meta-Analysis.

Elderly patients with distal radius fractures (DRFs) pose a significant medical challenge due to their high incidence and related healthcare costs. Both surgical methods like volar plate fixation and conservative approaches such as casting are common, yet their relative effectiveness remains unclear. This review and meta-analysis compare surgical and conservative treatments, focusing on wrist functionality, upper extremity performance, grip strength, and pain after one year.

Pedicle Flap Combined With Soft Tissue Graft for the Management of an Isolated Deep Buccal Recession in Auto-Transplanted Maxillary Molar: A Case Report.

This case report introduced a new technique to manage buccal deep isolated recession with loss of keratinized tissue. This technique is indicated where there is a good amount of keratinized tissue lateral to the defect and deep vestibule. In this case report, a 27-year-old male patient was referred to a periodontal surgery clinic for the management of an 8 mm buccal recession with loss of keratinized tissue related to auto-transplanted maxillary molar that caused discomfort to the patient.

The prevalence of dental anomalies among Saudi Population in Makkah, Saudi Arabia.

Background: Morphological and structural abnormalities are common dental anomalies. Identifying DA and determining their prevalence can play an important role in reducing the risk of surgical intervention and improving occlusion, leading to successful dental treatments. Thus, this study aimed to determine the prevalence of DA using panoramic radiographs (OPG) in Makkah, Saudi Arabia according to gender.

The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers.

Purpose: The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study investigated the variability in treatment recommendations for localized STS across different German-speaking tertiary sarcoma centers.

Wealth-based inequalities in tuberculosis prevalence among households having children and young adults in India: insights from Indian demographic and health surveys (2015-2021).

Background: Tuberculosis (TB) remains a significant health concern in India, especially among households with children and young adolescents aged 6-17 years. Despite ongoing research, there is a knowledge gap regarding specific risk factors for TB within this demographic. This study aims to bridge this gap by examining the association between TB and various socio-demographic factors, including socioeconomic status, nutritional status, and environmental conditions.

Apical periodontitis microbiome association with salivary and serum inflammatory burden.

Aims: Apical Periodontitis (AP) involves complex interactions between the root canal microbiome and the host immune response, with potential risk of local and systemic inflammatory burden, however there is no evidence available regarding correlation between microbiome and inflammatory marker levels. This study aims to identify the microbiome of saliva, intracanal and blood samples in AP subjects and investigate the correlation between intracanal and blood microbiomes with serum inflammatory biomarker levels, and salivary microbiomes with salivary inflammatory biomarker levels.

Methodology: Saliva, Intracanal and blood samples were collected from AP patients undergoing root canal retreatment.

Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study.

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited treatment options yielding poor outcomes. This study aimed to evaluate the real-world clinical characteristics, treatment patterns, and outcomes of patients with locally advanced unresectable and de-novo metastatic PDAC in Saudi Arabia, providing regional data to compare with international benchmarks.

Methods: This is a retrospective, multicentre study involving 350 patients diagnosed with unresectable locally advanced or de-novo metastatic PDAC between January 2015 and November 2023.

Biosynthesis and health promoting traits of green synthesized cobalt oxide nanoparticles.

Nanomedical applications have increased significantly. This work aimed to fabricate and characterize cobalt oxide nanoparticles (CoOnps) synthesized biologically via aqueous Alhagi maurorum extract and evaluate their cytotoxic and antimicrobial impacts. Green-synthesized CoOnps were prepared and analyzed using UV-Vis spectrophotometer UV-vis, Scanning electron microscopy (SEM), Transmission electron microscopy TEM, Energy dispersive X-ray analysis EDAX, Fourier transform infrared, FTIR, and X-ray diffraction (XRD).