Ultrastructural and morphometric study of regeneration dynamics in the rabbit lower jaw after Β-tricalcium phosphate transplantation.

Objective: Aim: The aim of this study is to determine the dynamics of histoarchitectural changes in the bone-ceramic regenerate after transplantation β-tricalcium phosphate into an experimental defect in the rabbit mandible.

Patients And Methods: Materials and Methods: Adult male rabbits aged 6-7 months and weighing 2.5-3 kg were used for the study.

The effect of the treatment and prevention complex on the activity of the antioxidant protection system in experimental periodontitis combined with stress.

Objective: Aim: To investigate the periodontal protective properties of the developed therapeutic and prophylactic complex in terms of pro- and antiradical protection system on an experimental toxic calcium-deficiency model of periodontitis under noise and cold stress.

Patients And Methods: Materials and Methods: Calcium-deficiency toxicity was modelled in animals with the addition of noise and cold stress. The effect of the developed therapeutic and prophylactic complex consisting of the oral gel and the food supplement on the indicators of pro- and antioxidant protection in the blood and periodontal tissues of rats was studied.

Practices of trauma-informed learning and their influence on the level of situational and personal anxiety of students who are studying face-to-face during hostilities.

Objective: Aim: To reveal the essence of trauma-informed learning in the context of the functioning of a person's inner world and the impact on changing the levels of situational and personal anxiety.

Patients And Methods: Materials and Methods: The study involved 900 people who are pursuing higher education during the military operations on the territory of Ukraine. Two parts of the Spielberger State-Trait Anxiety Inventory (STAI) questionnaire were used to determine low, medium, and high levels of situational and personal anxiety.

Gastroesophageal reflux disease: problematic issues of organising outpatient medical care for the adult population.

Objective: Aim: To determine the problematic issues of the organization of outpatient medical care for patients with gastroesophageal reflux disease (GERD) at the current stage by analyzing the incidence rates and the structure of visits to doctors of a medical institution over a 5-year period.

Patients And Methods: Materials and Methods: The reported data on the provision of outpatient medical care by doctors of various specialties to the adult population with GERD (ICD-10: К21, К44) from 01.01.

Significance of oxidative stress in liver damage of male and female rats with simulated ethanol hepatitis.

Objective: Aim: to find out the gender characteristics of oxidative mechanisms of liver damage in rats with ethanol hepatitis (EH).

Patients And Methods: Materials and Methods: The study was performed on 48 white male and female rats: 1 - control, 2 - acute EH (12,5 ml/kg of a 40% ethanol solution prepared on 5% solution of glucose for 7 days).The diene and triene conjugates (DC, TC), Schiff's bases (SB), TBA-active products (TBA-ap), activity of superoxide dismutase (SOD) and catalase (CAT) were determined in the blood serum.

Modelling business processes in palliative care management: ways to optimise resource management.

Objective: Aim: To evaluate the impact of corrective coefficients on the income of multidisciplinary mobile palliative care teams (MMPCT) in Ukraine under different scenarios, such as new contracts, patient count, and service cost variability, to identify optimization pathways for resource management in palliative care.

Patients And Methods: Materials and Methods: A comprehensive literature review was conducted, including sources from JAMA Scholar and PubMed. The Monte Carlo method simulated 10 000 scenarios of uncertainty, such as patient count and diagnoses, to assess the effect of corrective coefficients.

Early results of transabdominal preperitoneal inguinal hernia repair (TAPP) using invasive and non-invasive methods of mesh fixation.

Objective: Aim: To evaluate the early postoperative results of surgical treatment of patients with inguinal hernias after laparoscopic transabdominal preperitoneal inguinal hernia repair (TAPP) using invasive and non-invasive methods of fixation of prosthetic material.

Patients And Methods: Materials and Methods: The study included 76 patients (average age 61,4±15,3 years; 69 [91 %] males, 7 [9 %] females) with primary uncomplicated unilateral inguinal hernias who underwent TAPP. Patients were divided into two groups: group 1 - 52 patients in whom the AbsorbaTack fixation device was used to secure the mesh; group 2 - 24 patients in whom the LiquiBand FIX8 cyanoacrylate adhesive was used.

Modern combined approach to the surgical treatment of patients with post-traumatic tympanic membrane perforation due to blast injuries and eustachian tube dysfunction.

Objective: Aim: To improve the effectiveness of surgical treatment for patients with post-traumatic tympanic membrane perforations and concurrent Eustachian tube dysfunction through simultaneous combined surgical methods.

Patients And Methods: Materials and Methods: We analyzed clinical and functional outcomes of 35 patients (mean age: 34 ± 10,5 years) with tympanic membrane perforations caused by acoustic and blast injuries. The patients were divided into two groups: the first group (n=17) underwent only tympanoplasty type 1, while the second group (n=18) underwent simultaneous septoplasty, inferior turbinectomy, and tympanoplasty with prolonged middle ear ventilation using a subanular Silverstein tube.

Low anterior resection syndrome in distal rectal cancer patients and its correction methods.

Objective: Aim: To evaluate and compare the functional outcomes and quality of life in distal rectal cancer patients after low anterior resection with the formation of a transverse double-fold reservoir (TDFR) and without it.

Patients And Methods: Materials and Methods: The retrospective study enrolled 80 patients with distal rectal cancer: 40 patients who underwent low anterior resection with the formation of a TDFR, and 40 patients with the formation of a colorectal anastomosis (control group). The follow-up period was 10-60 months, with a median follow-up of 36 months after primary surgery.

The role of bone inflammation in the pathogenesis of maxillary sinus cyst formation.

Objective: Aim: To evaluate the role of maxillary bone inflammation in the formation of MSCs through the comprehensive assessment of histological and radiological research results and the determination of receptor activator of nuclear factor kappa-B (RANKL) in tissue homogenates, nasal secretions, and blood plasma.

Patients And Methods: Materials and Methods: We included 25 patients aged 20 to 65 with maxillary sinus cysts. We analyzed computed tomography and used enzyme-linked immunosorbent assay with human TNFSF11 (RANKL) in biological samples.

Periodontitis upon hypothyroidism of young people.

Objective: Aim: To study the periodontal tissues and to establish the Magnesium content in oral liquid and capillary blood of young people with hypothyroidism from areas with Iodine deficiency.

Patients And Methods: Materials and Methods: In order to study the prevalence of periodontal disorders there were 330 people aged from 25 to 44 years from areas with natural Iodine deficiency enrolled in this examination. Primary hypothyroidism was diagnosed in 195 people (they made up the group I), and 135 people did not have any accompanying endocrine pathology (group II).

Characteristics of therapeutic and diagnostic errors in the management of traumatic brain injury by healthcare professionals: insights from forensic medical examinations on the quality of medical care.

Objective: Aim: To identify defects in the diagnosis and treatment of traumatic brain injury (TBI) committed by medical personnel at various stages of providing medical care based on the results of forensic medical examinations.

Patients And Methods: Materials and Methods: The article based on the study of medical care defects in cases of TBI. The research was conducted according to the data of forensic medical examinations by the SI "Main Bureau of Forensic Medical Examination of the Ministry of Health of Ukraine" from 2012 to 2021.

The state of formation of a careful attitude towards health in the modern youth.

Objective: Aim: The aim of the study was to explore the factors that influence the development of a caring attitude toward health in modern youth as a foundation for an active life stance.

Patients And Methods: Materials and Methods: Various methods, including analysis of normative and scientific sources, systematic analysis, and empirical research, were employed. An anonymous survey of 114 pedagogical students was conducted to assess how much they value their health.

Follow-up performance of patients with cutaneous melanoma: recommendations for an effective strategy.

Objective: Aim: To investigate the incidence of progression and median time for metastasizing, the development of recurrent localization, and to identify localizations with a high tendency to recurrence of melanoma during 10 years of patient follow-up observation.

Patients And Methods: Materials and Methods: The retrospective data of dynamic observation by dermatovenereologists of SIS ≪CIHT≫ SAD of 183 patients with skin melanoma for the period 2014 - first half of 2024.

Results: Results: Among 183 cases of melanoma, 23 cases (12,6%) were detected in stage III and 11 cases (6,0%) in stage IV, so the neglect rate was 18,6%.

Assessment of society's readiness for the legalization of euthanasia, carried out in the field of palliative medicine.

Objective: Aim: To determine the signs of society's readiness to legalize euthanasia for palliative patients by interviewing both the patients themselves and their relatives (caregivers) and specialists who provide medical, psychological, social and spiritual services at the end-of-life.

Patients And Methods: Materials and Methods: The study was carried out using a sociological method among palliative patients of three regions of Ukraine (Lviv, Kyiv and Kharkiv) on a random sample of 377 people surveyed during 2022-2024. The conducted research confirmed and clarified the previous results with greater reliability.

Risk factors affecting the success of single-stage laparoscopic choledocholithiasis treatment: a retrospective analysis.

Objective: Aim: To identify and evaluate the risk factors affecting the success of single-stage laparoscopic treatment for choledocholithiasis.

Patients And Methods: Materials and Methods: We performed a retrospective analysis of treatment of 139 patients who underwent single-stage laparoscopic CBD exploration and cholecystectomy from 2018 to 2024. Data were analysed by the use of multivariate logistic regression to identify significant predictors of negative outcomes.

Kallikrein-kinin system pathogenetic importance in experimental benign prostatic hyperplasia.

Objective: Aim: To analyze the mechanisms of regulation of the body's proteolytic systems during inflammation, detection of inflammation markers in blood and prostate secretions in the experimental benign prostatic hyperplasia in rats.

Patients And Methods: Materials and Methods: The study was conducted on 30 male rats on the model of benign prostatic hyperplasia. Rats were randomized as following: the 1st group (n=6) - intact animals; the 2nd group (n=24) - rats with benign prostatic hyperplasia.

A nickel implant induces cell death through autophagy in the connective tissue capsule in an experimental model.

Objective: Aim: To identify cellular autophagy markers around nickel-containing implant as evidence of metal hypersensitivity reactions in an animal model.

Patients And Methods: Materials and Methods: Rats were sensitized to nickel using a modified model involving the administration of NiSO4 with adjuvants. Subsequently, nickel plate implants (Ni content at 98.

Potential and real dangers of the chemical warfare agents use during the full-scale invasion into Ukraine.

Objective: Aim: To analyze modern threats of the use of chemical warfare agents on the line of contact during the full-scale invasion into Ukraine.

Patients And Methods: Materials and Methods: The study was carried out with the use of theoretical methods (information retrieval, analytical, descriptive, generalization, system analysis and information synthesis) and the construction of trends with the identification of the coefficient of determination.

Results: Results: Most of damage cases of the military men of the Armed Forces of Ukraine were caused by the enemy's use of such groups of chemical warfare agents with an irritating effect as lacrimators and sternites, more specifically K-51 grenades with chloropicrin (PS) and 2-chlorobenzalmalononitrile (CS), RGR grenade with 2-chlorobenzalmalononitrile (CS) and RG-Vo (862-3-23) grenades with chloroacetophenone (CN).

Problems of harmonization of the criminal legislation of the certain continental law countries to ensure the protection of the circulation of medicinal products.

Objective: Aim: To find out the problems of the harmonization of the criminal legislation of the certain continental law countries to ensure the protection of the circulation of medicinal products.

Patients And Methods: Materials and Methods: This study is based on the analysis of the international legal acts, in particular, the Directives of the EU, as well as Medicrime Convention, national acts of criminal legislation of the certain continental law countries (Germany, Austria, Switzerland, Ukraine, etc.), national judicial practice, data on the number of criminal proceedings in the courts of Ukraine, criminal and medical law legal doctrine (38 normative legal acts and 15 court judgments), data of the Office of the Prosecutor General of Ukraine.

Impact of the Covid-19 pandemic and state of war on the availability and quality of mental health services.

Objective: Aim: To investigate the relationship between the COVID-19 pandemic and the conditions of state of war in Ukraine on the availability and quality of services in the field of mental health and to improve further research in this direction.

Patients And Methods: Materials and Methods: Bibliographic, epidemiological, sociological, statistical methods were used in the research. The sociological survey covered 315 respondents in Kyiv region and 206 respondents in Kyiv.

The problem of resilience of families with the consequences of war psychotrauma.

Objective: Аim: To determine the characteristics of family resilience to the consequences of war psychotrauma.

Patients And Methods: Materials and Methods: The experimental group included 23 young families (46 people, average age 28,20 ± 1,33 years) forcibly resettled from the zone of active hostilities; the control group consisted of 25 young families (50 people, average age 28,16 ±1,72 years) from Kyiv, who did not change their place of residence and did not witness active hostilities. The following psychodiagnostic methods were used questionnaires: "Diagnosis of personality behavior in a conflict situation"; "Communication in the family"; Marriage satisfaction test-questionnaire; Connor-Davidson-10 resilience scale.

Outcomes of implementing updated curricula for enhancing digital competence in undergraduate and post-diploma nursing education.

Objective: Aim: To assess the effectiveness of updated curricula in developing digital competence and enhancing the use of information and communication technologies in healthcare at the undergraduate and post-diploma levels of nursing education.

Patients And Methods: Materials and Methods: The updated 'Digigram for Healthcare Professionals' test tool, consisting of 75 questions, was utilized to assess the digital competence of 90 students and 136 practicing nurses before and after training in the Health Informatics curricula, updated through the USAID Health Reform project grant program at Zhytomyr Medical Institute in Ukraine during the first half of 2024. Additionally, the satisfaction of both groups with the curricula content was evaluated.

Diagnostic value of laboratory markers of enteric dysfunction in preterm infants.

Objective: Aim: To study the peculiarities of food tolerance disorders in premature infants, taking into account the risk factors of gestational age and maternal labor, the peculiarities of the course of perinatal pathology, in order to determine pathogenetically sound clinical and laboratory criteria.

Patients And Methods: Materials and Methods: A comprehensive clinical and laboratory evaluation was performed on 67 preterm infants of gestational age 32 to 33/6 weeks with severe food tolerance disorders in perinatal pathology. The comparison group consisted of 31 newborns with gestational age of 34 to 37 weeks.

Comparison of the experience and perception of artificial intelligence among practicing doctors and medical students.

Objective: Aim: To analyze and compare the experiences and perceptions of artificial intelligence (AI) among practicing doctors and medical students.

Patients And Methods: Materials and Methods: A survey was conducted among 30 doctors and 30 fifth-year master's students enrolled in the "Medicine" program. Participants were asked about their experiences with AI, their perceptions of AI's impact on their education and practice, and their views on the benefits and drawbacks of AI in the medical field.