Tunable TiZrMoC Coatings: A Comprehensive Study of Microstructure, Mechanical Properties, and Wear Resistance.

TiZrMoC coatings were deposited on Si(100) substrates using a DC dual magnetron sputtering. The composition was controlled by adjusting the sputtering parameters of the TiZrMo and graphite targets. The influence of graphite target current on the resulting coating properties was explored.

Evaluation of Fifteen 5,6-Dihydrotetrazolo[1,5-]quinazolines Against : Integrating In Vitro Studies, Molecular Docking, QSAR, and In Silico Toxicity Assessments.

(), the second most prevalent Candida pathogen globally, has emerged as a major clinical threat due to its ability to develop high-level azole resistance. In this study, two new 5,6-dihydrotetrazolo[1,5-]quinazoline derivatives ( and ) were synthesized and characterized using IR, LC-MS, H, and C NMR spectra. Along with 13 previously reported analogues, these compounds underwent in vitro antifungal testing against clinical isolates using a serial dilution method (0.

Functional interaction of melatonin with gasotransmitters and ROS in plant adaptation to abiotic stresses.

Melatonin is considered a multifunctional stress metabolite and a novel plant hormone affecting seed germination, root architecture, circadian rhythms, leaf senescence, and fruit ripening. Melatonin functions related to plant adaptation to stress stimuli of various natures are considered especially important. One of the key components of melatonin's stress-protective action is its ability to neutralise reactive oxygen species (ROS) and reactive nitrogen species directly.

ANATOMY OF THE MAXILLARY SINUS: IMPLICATIONS FOR ODONTOGENIC SINUSITIS DEVELOPMENT.

Unlabelled: This study investigates the anatomical prerequisites that could contribute to the development of this condition.

Material And Methods: Using multi-slice computed tomography (MSCT), the study examined the structure and relationships of key anatomical features, including the alveolar process, sinus wall thickness, and the position of the teeth in relation to the maxillary sinus.

Results: The results revealed that the lower wall of the maxillary sinus is predominantly formed by the alveolar process, with significant variability in wall thickness, especially between the central and lateral regions.

POSSIBILITY OF IMPROVING DISEASE PREDICTION USING MATHEMATICAL MODELS.

Throughout their existence, people have sought to know what tomorrow holds for them. It was especially important to learn about a full life, illness or death. Science is the essence of human knowledge, which is organized according to certain principles, a real connection of judgments, predictions and problems of reality and its individual spheres or aspects.

PECULIARITIES OF THE SECOND MESIOBUCCAL CANAL IN MAXILLARY FIRST MOLAR: A RETROSPECTIVE ANALYSIS.

Unlabelled: The first maxillary molar is one of the most difficult teeth for endodontical treatment; it presents the highest failure rates due to the impossibility of locating and treating the second mesiobuccal canal (MB2). The aim of our work was study of second mesiobuccal canal in maxillary first molar and compare obtained data with literature sources for increasing the efficiency of treatment.

Materials And Methods: The study involved 59 patients with exacerbation of chronic pulpitis or chronic periodontitis who were distributed according to age: 14-20 years, 21-30 years and 31-40 years.

Near-infrared light therapy normalizes amyloid load, neuronal lipid membrane order, rafts and cholesterol level in Alzheimer's disease.

Cholesterol dysregulation, disorder of neuronal membrane lipid packing, and lipid rafts lead to the synthesis and accumulation of toxic amyloid-β (Aβ), contributing to the development of Alzheimer's disease (AD). Our study shows that near-infrared (NIR) transcranial photobiomodulation therapy (tPBMT) can reduce Aβ load and restore the properties of neuronal plasma membrane, including Aβ production, bilayer order, rafts, lipid content, and Ca channels during AD. Mice in the experiments were exposed to 808-nm LED for 1 h daily over 3 months.

MOLDOVA - SYSTEMATIC PREPAREDNESS FOR MEDICAL RESPONSE TO RADIATION EMERGENCIES.

Under the conditions of a full-scale russian invasion of Ukraine, the danger of the development of radiation and nuclear emergency situations in the region has increased significantly. An external independent assessment of the ability of health care system of the Republic of Moldova to respond to emergency situations revealed the need to develop a training program for medical workers on the basics of responding to radiation and nuclear threats. In addition, the evaluation recommended the development of a standard for victims care taking into account the existing evidence base.

IMPLEMENTATION OF THE EDUCATIONAL MODULE «MANAGING EXPOSURE ASSESSMENT AND MEDICAL RESPONSE TO A RADIATION EMERGENCY IN UKRAINE».

The WHO educational module УДК «Ma naging exposure assessment and medical response to a radiation emergency in Ukraine» was developed and implemented. In total, 25 trainings were conducted for 377 healthcare professionals from 6 regions of Ukraine during 2023-2024.

INTEGRATING RADIOLOGICAL IMAGING TECHNIQUES INTO ANATOMY EDUCATION: MEDICAL TRAINING ENHANCEMANT THROUGH EARLY CT AND MRI TEACHING.

Unlabelled: Brain morphology understanding is essential for radiologists, neurologists, and neurosurgeons. Historically, anatomical learning of brain relied on ex vivo specimens. Modern in vivo brain CT and MRI provide spatial, three-dimensional imaging capabilities crucial to help diagnose diseases, plan surgeries, and monitor treatment progress.

SYNCHRONOUS COLON CANCER ASSOCIATED WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA. CLINICAL CASE.

We present а rare clinical case of successful surgical treatment - combined left-sided hemicolectomy and cecal resection for colon cancer of two locations in a patient with idiopathic thrombocytopenic purpura, which, in our opinion, is due to radiation exposure is presented. It is shown that the biological effects of long-term ionizing radiation on critical organs can have a diverse nature both in terms of the time of occurrence and in their structure, which requires an individual approach, the involvement of related specialists and the necessary medical preoperative preparation for precise planning of surgical intervention taking into account all possible risks.

BIOCHEMICAL MARKERS OF MISCARRIAGE ASSOCIATED WITH THE INTRAPLACENTAL ACCUMULATION OF 137Cs.

Unlabelled: The impact of the environment on human health in modern conditions cannot be underestimated. The study of thepathogenesis of disease is impossible without establishing the factors of destabilization of biological membranes.The article highlighted the problem of lipid peroxidation and antioxidant defense associated with the accumulationof radiocesium in the placenta.

A COMPARATIVE STUDY OF CARDIOVASCULAR TOXICITY OF EPIRUBICIN AND DOXORUBICIN IN PATIENTS WITH BREAST CANCER.

Unlabelled: Patients with breast cancer (BC) are at high risk of cardiotoxicity (CT) due to combination of anticancer treatment.Cardio-vascular (СV) complications lead to the delay or discontinuation of anticancer therapy, which significantlyworsens the prognosis. Anthracyclines (AC) are the main drugs included in most anticancer treatment regimens.

PATTERNS OF DEVELOPMENT OF CLINICAL AND FUNCTIONAL DISORDERS OF THE BRONCHOPULMONARY SYSTEM IN THE POST-ACCIDENT PERIOD IN PERSONS EXPOSED TO IONIZING RADIATION.

The objective was to study the relationship between clinical symptoms and the functional state of the bronchopulmonary system of clean-up workers of the Chornobyl Nuclear Power Plant accident with chronic obstructive pulmonary disease in the remote post-accident period.Materials and methods. A retrospective analysis of 824 cases of COPD in male patients who underwent inpatienttreatment in the radiation pulmonology department from 2014 to 2024 was conducted.

STRUCTURE AND CHARACTERISTICS OF THE CHORNOBYL NPP ACCIDENT SURVIVORS REASONS OF DEATH ACCORDING TO THE MATERIALS OF MEDICAL EXPERTISE FOR THE CAUSAL RELATIONSHIP OF DISEASES WITH THE EFFECT OF IONIZING RADIATION IN THE REMOTE POSTACCIDENTAL PERIOD (2024 year).

Unlabelled: Problem of the causal relationship of disease that became the reason of death with the effect of ionizing radiation and due to harmful influence of the Chornobyl Catastrophe during performance of professional, military or official duties and / or living on radiation-contaminated areas, additional exposure not through their own fault but due to a radiation accident, caused the development of a special form of medical expertise as part of the of medical social protection system for suffered contingents in the remote postaccidental period.

Objective: To study and characterize the structure of the survivor categories (clean-up workers and victims) of the Chernobyl Catastrophe in the remote post-accident period (2013-2024) regarding the causal relationship of disease that became the reason of death with the effect of ionizing radiation and due to harmful influence of the Chornobyl Catastrophe based on the materials of expert cases of the Central Interdepartmental Expert Commission of the Ministry of Health of Ukraine (CIEC).

Material And Methods: The work was performed in the design of a retrospective study that based on analysis of the structure of all categories of Chornobyl NPP accident (ChNPP) survivors during 2008-2024 years and studying of 58,137 medical expert cases, including 19,524 postmortem cases, which were considered by CIEC during 2013-2023 to establish a causal relationship between the disease and influence of radiation exposure and other harmful factors and conditions during ChNPP accident.

RELATIONSHIP OF THE PERCEIVED STRESS LEVEL, ANTHROPOMETRIC INDICATORS AND BODY COMPOSITION IN CHILDREN EXPERIENCING PERMANENT NEGATIVE IMPACT OF THE COVID-19 PANDEMIC AND THE WAR IN UKRAINE.

Objective: to assess the impact of stressful life events occuring with the period of restrictive measures introductionconnected to the COVID-19 pandemic and during the full-scale Russian aggression, on the anthropometric indicators and body composition of children aged 10-17 years.

Materials And Methods: The research group consisted of 56 boys and 70 girls aged 10-17 years who lived in radioactively contaminated areas of Zhytomyr, Rivne, and Kyiv regions with a soil contamination density of 137Cs from 18 kBq/m2 to 235 kBq/m2. The impact of stressful factors was assessed using the stress perception scale (PSS-10).

POST-RADIATION NEUROCOGNITIVE DEFICIT IN THE CHORNOBYL CLEAN-UP WORKERS: GERIATRIC ASPECTS (PART І).

Objective: to study the features of cognitive disorders in the remote period following exposure to ionizing radiation (IR) in the elderly participants of the liquidation of the consequences of the Chornobyl NPP accident (Chornobyl clean-up workers) with chronic cerebrovascular disorders.

Materials And Methods: The retrospective and prospective cohort study with the external and internal controlgroups. The randomized sample of the male elderly participants (attained age more than 60 years old) in liquidationof the consequences of the accident (Chornobyl clean-up workers, liquidators) at the Chornobyl nuclear power plant(ChNPP) in 1986-1987 (main group, n = 52) recruited from the Clinico-epidemiological registry (CER) of StateInstitution «National Research Center for Radiation Medicine, Hematology and Oncology of The National Academyof Medical Sciences of Ukraine» (NRCRMHO) with verified chronic cerebrovascular disorders (CVD) was examined.

SUPEROXIDE DISMUTASE (SOD2) GENE VAL16ALA POLYMORPHISM AND CHANGES IN THE VENTILATION LUNG CAPACITY OF CHILDREN - RESIDENTS OF RADIOACTIVELY CONTAMINATED TERRITORIES AND CHILDREN WHO HAVE BEEN AFFECTED BY STRESSFUL LIFE EVENTS DURING WARTIME.

Objective: to determine the distribution of genotypes of genetic polymorphism of manganese superoxide dismutaseand to assess the ventilation lung capacity in children- residents of radioactively contaminated areas and childrenexposed to stressful life events during the war period.

Materials And Methods: The study involved school-age children - residents of radioactively contaminated areas(RCA) and children exposed to stressful life events during wartime. All those examined had no clinical signs of respiratory pathology.

DYSREGULATION OF AUTOPHAGY IN PERIPHERAL BLOOD LEUCOCYTES IS A FACTOR IN THE DEVELOPMENT OF INFLAMMAGING IN IMMUNOCOMPROMISED PERSONS ON THE EXAMPLE OF THE SERVICEMEN OF THE DEFENSE FORCES OF UKRAINE AND CLEAN-UP WORKERS OF THE CHORNOBYL ACCIDENT.

Objective: To assess the functional state and age-related characteristics of autophagy in peripheral blood leukocytes as a risk factor for the development of inflammaging using the example of the servicemen of the DefenseForces of Ukraine and clean-up workers of the Chornobyl accident.

Materials And Methods: A total of 103 male patients aged 28-77 (56,48 ∓ 9,05) years were examined. They included: the main group - 23 servicemen of the Defense Forces of Ukraine aged 44-59 (50,21 ∓ 5,13) years; the comparison group - 57 clean-up workers of the Chornobyl accident aged 56-63 (60,31 ∓ 1,78) years; and the control group -23 civilians aged 28-77 (53,26 ∓ 15,98) years.

STATE OF CARDIOVASCULAR SYSTEM IN SERVICEMEN OF UKRAINE ARMED FORCES AND EMERGENCY WORKERS OF THE CHORNOBYL ACCIDENT. COMPARATIVE ANALYSIS.

Objective: To conduct a comparative analysis of cardiovascular system state in emergency workers (EW) of theaccident at the Chornobyl NPP and servicemen (SM) of Ukraine Armed Forces (UAF) who took part in the fightagainst russian military aggression, and to assess the role of military service factors on the development of cardiac pathology.

Materials And Methods: The study included 81 male EW and 161 SM of UAF, who were examined and treated in thecardiology department of NRCRMHO from 2022 to 2024. The average age of the surveyed EW was (56.

MOLECULAR-GENETIC PHENOTYPES OF BREAST CANCER, THEIR PROLIFERATIVE ACTIVITY, DEGREE OF SPREADING AND DIFFERENTIATION IN PATIENTS WHICH WERE SUFFERED BY THE ACCIDENT AT ChNPP.

Objective: analysis of molecular genetic phenotypes, their proliferative activity, degree of spread and differentiation of tumors in breast cancer patients affected by the accident at the Chornobyl Nuclear Power Plant.

Materials And Methods: 96 breast cancer patients who were exposed to ionizing radiation as a result of the accident at the Chornobyl Nuclear Power Plant were examined. Clinical, radiological, instrumental, morphological,immunohistochemical research methods were used.

ELECTROPHYSIOLOGICAL CHANGES IN THE PARTICIPANTS OF THE LIQUIDATION OF THE CONSEQUENCES OF THE CHORNOBYL ACCIDENT AND THE MILITARY PERSONNEL OF THE UKRAINIAN DEFENSE FORCES RECOVERING FROM CORONAVIRUS DISEASE (COVID-19).

Objective: to conduct a clinical and neurophysiological study of Chornobyl clean-up workers and military personnelof the Armed Forces of Ukraine (AFU) with previous coronavirus disease (COVID-19) and individuals of the comparison groups to study the impact of long-term effects of ionizing radiation, psychoemotional stress and previouscoronavirus infection on cerebral functioning.

Materials And Methods: A prospective clinical study of Chornobyl clean-up workers and servicemen of the ArmedForces of Ukraine (AFU) who had coronavirus disease (COVID-19) and individuals of the comparison groups. Themain group - 30 males participated in liquidating the consequences of the Chornobyl Nuclear Power Plant (ChNPP)accident with previously verified COVID-19 (Chornobyl clean-up workers).

STRUCTURAL AND FUNCTIONAL BONE FEATURES IN CHILDREN RESIDING IN THE RADIOLOGICALLY CONTAMINATED TERRITORIES OF UKRAINE.

Objective: Evaluation of structural features and metabolic/biochemical abnormalities of the bone tissue and relevant regulation patterns in children, residing in the radiologically contaminated territories (RCT).

Materials And Methods: Children (n = 148) aged 7 to 18 years old were involved in the study. Bone mineral density (BMD) is given in 3 grades according to the mean square deviation values, namely Grade I - standard (n = 75),Grade II - reduced (n = 45) and Grade III - very low one (n = 28).