Nowadays and the future of the 3d digital technologies in modern orthodontics.

Objective: Aim: To investigate the usage trends of different 3D digital technologies in modern orthodontics during the previous eight years to identify their future prospects.

Patients And Methods: Materials and Methods: A systematic literature search on PubMed revealed 258,059 publications concerning digital technologies in modern orthodontics. Amongst 125 eligible articles, we chose 37 high quality articles.

Correction of dysmenorrhea in teenage girls with autonomic dysfunction syndrome.

Objective: Aim: The aim of our study was detection and correction of dysmenorrhea in teenage girls with autonomic dysfunction syndrome.

Patients And Methods: Materials and Methods: The research group consisted of 37 teenage girls, aged 12-16 years, who were undergoing rehabilitation treatment with signs of dysmenorrhea and vegetative dysfunction syndrome. The study lasted for 2 years (2020-2021).

Clinical and diagnostic features of Crohn's disease in young children.

Objective: Aim: To highlight the distinctive features of CD in young children, based on personal clinical experience in observation and treatment, with the objective of improving the accuracy of diagnosis and the effectiveness of treatment.

Patients And Methods: Materials and Methods: The study involves the results of treatment 11 young children with CD. The diagnosis was based on the combination of the following data: clinical manifestations of the disease and its course, as well as the results of laboratory, instrumental, and step biopsy with morphological studies.

Peculiarities of neurovegetative regulation in children and adolescents with sarcopenia according to heart rate variability indicators.

Objective: Aim: To find what extent the state of neurovegetative regulation in children and adolescents with sarcopenia differs from their peers without signs of sarcopenia.

Patients And Methods: Materials and Methods: The sarcopenic index and hand grip strength, which were simultaneously in the range below the 25th percentile of the reference values of these indicators for the corresponding age and gender, were considered the criteria for sarcopenia. A bioelectrical impedance analyzer, "TANITA MC- 780 MA" (Japan), was used to obtain the SI indicator.

Differentiated approach to management of patients with irritable bowel syndrome and ulcerative colitis in non-alcoholic fatty liver disease.

Objective: Aim: To determine the main clinical and laboratory features and severity of colon dysbiosis in irritable bowel syndrome (IBS) and IBD in patients with NAFLD.

Patients And Methods: Materials and Methods: 80 patients with NAFLD were examined. Patients were divided into two groups.

Iron deficiency and heart failure with preserved ejection fraction.

Objective: Aim: We aimed to assess the prevalence of ID in patients HFpEF and its relation to functional capacity and quality of life.

Patients And Methods: Materials and Methods: We included in the analysis 121 consecutive outpatients newly diagnosed of HFpEF and tested with iron-related parameters. Patients were subdivided in two groups according to the presence of ID (n = 76, mean age 65.

Specifics of barrier function impairment of the large intestine in patients with ulcerative collitis and joint damage.

Objective: Aim: To study the characteristics of barrier function impairments of the large intestine in patients with UC and concomitant joint damage.

Patients And Methods: Materials and Methods: At the clinical base of the Department of Therapy and Family Medicine, 80 patients with inflammatory bowel disease (IBD) were examined. Patients with IBD were divided into two groups.

Analysis of the intensity of carious infection of teeth in children permanently living in conditions of a pollated ecosystem.

Objective: Aim: Assessment of dental caries and its impact on the level of dental health of children aged 15-18 years of Upper Tysa region, who constantly live in conditions of combined negative effects of factors of natural and technological genesis.

Patients And Methods: Materials and Methods: During the dental examination, the incidence of dental caries in 360 children aged 15-18 years from various biogeochemical zones of the cross-border region of the Upper Tysa region was studied and assessed using the International Caries Detection and Assessment System - ICDAS II (International Caries Detection and Assessment System).

Results: Results: It was found that the use of physiologically suboptimal drinking water from decentralized water resources is among the environmental determinants of the state of dental health of children in the Upper Potyssia.

Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes mellitus.

Objective: Aim: To conduct a comparative analysis of the effectiveness of basic therapy and basic therapy with the inclusion of quercetin in patients with COVID-19 with concomitant type 2 diabetes.

Patients And Methods: Materials and Methods: There were examined 60 patients with COVID-19 with concomitant T2DM. Upon admission into the hospital and again after 10 days, serum levels of interleukin-6, C-reactive protein, procalcitonin, ferritin, endothelin-1 were determined, and capillaroscopy of the nail plate was performed.

Serotonin levels in children with cognitive impairment in delayed speech development in non-alcoholic fatty liver disease with obesity and Covid-19.

Objective: Aim: To identify features of changes in serum serotonin and tryptophan levels in children with cognitive impairment (CI) and delayed speech development (DSD) at non-alcoholic fatty liver disease (NAFLD) and COVID-19.

Patients And Methods: Materials and Methods: The study included 108 children with CI and DSD at NAFLD. The children were divided into 2 groups: group 1 included children with COVID-19 (n=58); group 2 consisted of 50 children without COVID-19.

Violation of vitamin and mineral homeostasis in children with recurrent respiratory diseases.

Objective: Aim: To examine and analyze the state of vitamin and mineral homeostasis in children with recurrent respiratory diseases.

Patients And Methods: Materials and Methods: To achieve the goal, 62 children of primary school age with a diagnosis of Recurrent Respiratory diseases were examined in comparison with data of healthy children of the control group (n=26). The study included a clinical examination of children, determination of serum vitamin and mineral levels.

Dynamic indicators of the antioxidant system in children with acute respiratory pathology depending on the therapy scheme.

Objective: Aim: To improve the early diagnosis, course, prediction of the development of Acute Respiratory pathology in children, taking into account the state of antioxidant system (AOS).

Patients And Methods: Materials and Methods: The research group included school-age children (10-14 years old) with Acute Respiratory pathologe (n=111) and a control group (n=25).diseases in comparation.

Local anesthesia in adolescents with high anxiety levels.

Objective: Aim: To assess the effectiveness of local anesthesia in the treatment of acute forms of caries, pulpitis, and periodontitis in adolescents with a high level of baseline anxiety.

Patients And Methods: Materials and Methods: 1.7 ml of local amide anesthetic from the articaine series was used.

Molecular-genetic characteristics of hmgb1 mrna expression in blood of women with endometriosis associated with infertility.

Objective: Aim: To examine HMGB1 expression in the blood of women with endometriosis-associated infertility and to establish its role in disease progression.

Patients And Methods: Materials and Methods: We analyzed HMGB1 gene expression levels in two groups: 20 women with endometriosis-associated infertility (main group) and 10 healthy women (control group). The study was conducted at Bukovinian State Medical University and the Centre of Reproductive Medicine.

The second week corneal changes in rodents model of streptozotocin-induced diabetes.

Objective: Aim: Installation the changes of the microstructural rearrangement of the layers of the rat cornea at the end of the second week of experimental streptozotocin- induced diabetes.

Patients And Methods: Materials and Methods: The research was conducted on 15 sexually mature, outbred white male rats, weighing 120-130 g. Two groups of animals were used in the work: the first group with developing diabetes (2 weeks after administration of streptozotocin); the second group served as control and received injections of 0.

Epidemiology of complications associated with gynecological laparoscopy procedures in Ukraine: results a multicenter study.

Objective: Aim: To estimate the frequency of complications during laparoscopic gynecologic surgery for benign diseases in women and identify associated risk factors in Ukraine.

Patients And Methods: Materials and Methods: A multicenter, prospective cohort study was performed in gynecological departments from 10 regional hospitals of Ukraine between January 1, 2020, to December 31, 2022. The study included gynecologic laparoscopies for benign diseases in women performed at these hospitals.

Influence of elemental composition on the stability of restorative structures in permanent teeth in children from different geographical areas of residence.

Objective: Aim: To evaluate the correlation between the mineral composition of the hard tissues of the teeth and the percentage of defects and loss of various restorative materials in permanent teeth in children living in the lowland and mountainous geographical zones of Transcarpathian region.

Patients And Methods: Materials and Methods: 1050 permanent teeth of different groups filled with different materials were studied. An ultra-microscopic examination by the method of raster electron microscopy was carried out and the mineral composition of the teeth was evaluated.

Endometrial hyperplasia as a consequence of mixed urogenital infections.

Objective: Aim: Investigation of hyperproliferative diseases of the female genital organs as a consequence of mixed urogenital infections.

Patients And Methods: Materials and Methods: The study included 56 women of reproductive age who experienced discomfort in the external genital area in the form of excessive vaginal discharge and/or unpleasant odour of the discharge, itching in the external genital area (main group). The control group consisted of 30 somatically and gynaecologically healthy patients.

Analysis of the prevalence of allergic rhinitis among children in Uzhhorod.

Objective: Aim: To analyze data on the prevalence of allergic rhinitis (AR) among children in Uzhhorod.

Patients And Methods: Materials and Methods: 373 patients who consulted a pediatric allergist at the Uzhgorod City Children's Polyclinic were under observation.

Results: Results: After examination of 373 patients with AR, it was found that girls predominated by gender, namely 54.

Intra-abdominal hypertension and pancreatic destruction in patients with acute necrotizing pancreatitis.

Objective: Aim: To determine the relationship between intra-abdominal hypertension and the volume of pancreatogenic necrosis in patients with acute necrotizing pancreatitis.

Patients And Methods: Materials and Methods: A prospective single-center study of 32 adults with acute necrotizing pancreatitis (ANP). A correlation was made between the maximum intra-abdominal pressure (IAP) in the early phase of the disease and the area of pancreatic necrosis and extrapancreatic necrosis (EPN) according to CT data.

Anastomotic leak: genetic aspects of prediction and choice of surgical treatment tactics.

Objective: Aim: To improve the treatment results of patients with anastomotic leaks by studying genetic predisposition.

Patients And Methods: Materials and Methods: The object of this prospective study were 17 patients with anastomotic leaks. A group of 80 practically healthy people was tested as control.

Biomarker diagnostics of endothelial dysfunction in patients with acute coronary syndrome and non-alcoholic fatty liver disease.

Objective: Aim: To determine the severity of endothelial dysfunction (ED) in patients with acute coronary syndromes (ACS) in non-alcoholic fatty liver disease (NAFLD).

Patients And Methods: Materials and Methods: The study included 124 patients with ACS. Group 1 included 74 patients after ACS and NAFLD, and group 2 consisted of 50 patients after ACS without liver damage.

From open-ended to multiple-choice: evaluating diagnostic performance and consistency of ChatGPT, Google Gemini and Claude AI.

Objective: Aim: To determine the performance and response repeatability of freely available LLMs in diagnosing diseases based on clinical case descriptions.

Patients And Methods: Materials and Methods: 100 detailed clinical case descriptions were used to evaluate the diagnostic performance of ChatGPT 3.5, ChatGPT 4o, Google Gemini, and Claude AI 3.