Genome-wide identification and diversity of FAD2, FAD3 and FAE1 genes in terms of biotechnological importance in Camelina species.

Background: False flax, or gold-of-pleasure (Camelina sativa) is an oilseed that has received renewed research interest as a promising vegetable oil feedstock for liquid biofuel production and other non-food uses. This species has also emerged as a model for oilseed biotechnology research that aims to enhance seed oil content and fatty acid quality. To date, a number of genetic engineering and gene editing studies on C.

Calm me down, or I'll leave: anxiety and institutional support among Ukrainian academic staff during wartime.

Background: Mental health conditions among academic staff are a growing global concern, driven by factors such as heavy workloads, job insecurity, and a lack of institutional support. Anxiety, one of the most common mental health problems, is particularly widespread in academia, affecting cognitive function and productivity. In Ukraine, the ongoing war has intensified these challenges, creating unprecedented working conditions for academic staff.

Flow-diverting stents for the treatment of unruptured distal anterior cerebral artery aneurysms: analysis of the CRETA Registry.

Background: Data about the safety and the efficacy of flow diversion for distal anterior cerebral artery (DACA) aneurysms are limited. We present the largest multicenter analysis evaluating the outcomes of flow diversion in unruptured DACA aneurysm treatment.

Methods: Databases from 39 centers were retrospectively reviewed for unruptured DACA aneurysms treated with flow-diverting stents.

Gut Microbiome as a Target for Anti-ageing Interventions.

Trillions of various microorganisms inhabit the human intestine whilst having myriads of effects on the body. They participate in the metabolism of nutrients, support the work of the immune system, regulate operation of the nervous system, and produce vitamins, short-chain fatty acids, and a number of other compounds necessary for the host. An imbalance or disruption in the normal microbial community is called dysbacteriosis or dysbiosis.

The October 7, 2023, Attack on Israel Indicates a Change in Trauma Patterns of Terror Victims, due to the Use of Thermobaric Weapons.

Introduction: The terror attack on October 7, 2023, in southern Israel resulted in approximately 1,200 civilians and security personnel killed. Of the civilians murdered, approximately 200 men, women, and children were murdered inside their homes, while the remaining casualties were murdered in an open field at a music festival, in their cars, or in the streets of local cities.

Materials And Methods: Currently, official data have not yet been published regarding the types of injuries suffered by Israeli civilians during the terror attack.

Effects of Alkali-Metal Counterions on the Vibrational Dynamics of the DNA Hydration Shell.

The effects of alkali-metal ions (Li, Na, K, Rb, and Cs) on the vibrational dynamics of the DNA ion-hydration shell were studied through classical molecular dynamics simulations. As a result, the vibrational spectra of the DNA-water-salt systems were calculated within the framework of two approaches, using dipole-dipole and velocity-velocity autocorrelation functions. We dissect the effect of the individual compartments of the DNA double helix (minor groove, major groove, and phosphate groups) on the behavior of the systems.

Efficacy of Wilate Prophylaxis in Reducing Nosebleeds in Patients with Severe VWD - A Post-hoc Analysis of the WIL-31 Study.

Background: Prophylaxis with a von Willebrand factor (VWF) concentrate is recommended in von Willebrand disease (VWD) patients with a history of frequent and severe bleeds. Despite nosebleeds being a frequent manifestation of VWD, few studies have investigated the efficacy of factor prophylaxis in preventing nosebleeds in patients with severe VWD.

Methods: This post-hoc analysis of a prospective, 12-month, phase 3 study assessed the efficacy of wilate in the prevention of nosebleeds in 33 patients aged ≥6 years with severe type 1, type 2 or type 3 VWD.

Intermetallic Materials for High-Capacity Hydrogen Storage Systems.

In this article, we provide an overview of hydrogen storage materials, taking our previous results as examples. Towards the end of the paper, we present a case study in order to highlight the effects of substitutional alloying, compositional additives, and nanostructuring on the hydrogen sorption properties of magnesium-based intermetallics. Specifically, partial substitution of Mg by Li and d-elements by p-elements leads to structural changes, inducing disorder and the formation of high-entropy alloys.

Support for temporary protection of displaced populations in the EU: A conjoint experiment.

Millions of people were forced to flee Ukraine after Russia's invasion on February 24, 2022, one of the fastest displacements in decades. Citizens' response in EU countries (where most displaced Ukrainians arrived) has been considerably more positive than in past refugee crises. This study investigates several possible drivers of this difference.

Fluctuations of Anterior Chamber Depth and Astigmatism in Pseudophakic Eyes.

Purpose: To explore the significance of changes in anterior chamber depth (ΔACD) and astigmatism between 4 and 8 weeks following uneventful phacoemulsification.

Patients And Methods: Anterior chamber depth (ACD, mm), autorefractometry and subjective refraction were monitored in pseudophakic eyes implanted with non-toric IOLs (group 1, SA60AT, n=36; group 2, SN60WF, n=34; group 3, ICBOO, n=16) and phakic control group (n=30, group 4a, for ACD and autorefractometry) over four weeks. Changes in subjective refractions were compared with repeatability in normal phakic eyes (n=30, group 4b).

Transitions in growing networks using a structural complexity approach.

Structure changes or transitions are common in growing networks (complex networks, graphs, etc.) and must be precisely determined. The introduced quantitative measure of the structural complexity of the network based on a procedure similar to the renormalization process allows one to reveal such changes.

High drug-loaded amorphous solid dispersions of a poor glass forming drug: The impact of polymer type and cooling rate on amorphous drug behaviour.

Enhancing the aqueous solubility via amorphization of crystalline poor glass-forming drugs represents a challenge, particularly when drug dosing is high. In such scenarios, there is often a need for high polymer loadings, leading to an increase in the dosage form mass and less patient acceptability. This work investigated the role that polymer type and after-melt cooling rate had upon the amorphicity of solid dispersions (SDs) containing high levels of naproxen and three commonly used polymeric excipients: Eudragit® EPO, Kollidon® VA64, and Soluplus®.

Occupational safety of healthcare workers in the terms of the Covid-19 pandemic as the public health aspect.

Objective: Aim: To assess the level of occupational safety, health and hygiene of healthcare workers in the terms of the COVID-19 pandemic..

Patients And Methods: Materials and Methods: bibliosemantic, bibliographic, analytical, statistical methods as well as a systemic approach have been used in the research.

International standards for conducting biomedical research with human participation.

Objective: Aim: To conduct a comprehensive analysis and systematization of international standards for biomedical research involving human participants, to identify their key principles and implementation mechanisms, as well as to evaluate their effectiveness in ensuring ethical and legal norms during such research..

Patients And Methods: Materials and Methods: This research employs a diverse array of scientific inquiry methods, encompassing both general scientific approaches and specialized techniques.

The role of university clinics in advancing higher medical education.

Objective: Aim: To explore the multifaceted role of university clinics in shaping medical professionals, advancing medical knowledge, and improving healthcare delivery. Special attention is given to their function as primary platforms for practical training, the development of professional competencies, and the implementation of innovative teaching methods in medical education..

The severity and outcome of Covid-19 depend on the various activities of the renin-angiotensin-aldosterone system, level of the opioid growth factor, [met5]-enkephalin and pre-existing comorbidities.

Objective: Aim: The aim of the study was evaluation of the methionine-enkephalin in patients with severe COVID-19 with various activities of the renin-aldosterone system in comparison with COVID-19 patients with pre-existing comorbidities (renal cell cancer, critical limb ischemia) and adverse pregnancy outcomes..

Patients And Methods: Materials and Methods: To test our hypothesis, this case-control study consisted of 20 healthy donors (control group); 49 patients with a positive diagnosis of COVID-19 according to PCR analysis; 15 patients with a positive diagnosis of COVID-19 in combination with renal cell cancer; 29 patients with a positive diagnosis of COVID-19 in combination with critical limb ischemia, 10 pregnant womens with COVID-19.

Peculiarities of leadership qualities manifestation by modern managers of police organizations: psychological aspect.

Objective: Aim: To study the psychological peculiarities of the manifestation of leadership qualities by modern managers of police organizations..

Patients And Methods: Materials and Methods: The research conducted in 2022-2024 involved 64 mid-level managers of police organizations and 462 officers from police units directly subordinated to these managers.

The role of intraoperative angiography in treating acute lower limb artery occlusion.

Objective: Aim: To compare the results of surgical treatment of patients with acute lower limb artery occlusion with and without intraoperative angiography..

Patients And Methods: Materials and Methods: Comparative analysis was conducted on the surgical treatment outcomes of 119 patients with acute lower limb artery occlusion treated at the Vascular Surgery Center of the Clinical Hospital ≪Feofaniya≫ State Administrative Department from 2017 to 2022.

Pentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod.

Objective: . Aim: To find out the influence of melatonin on the enzyme activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase in the liver of rats with alloxan diabetes under conditions of variable photoperiod.

Patients And Methods: Materials and Methods: Experiments were conducted on male outbred white rats weighing 180±10 mg.

Evaluation of the treatment effectiveness in children with coronavirus infection.

Objective: Aim: To study and analyze the treatment effectiveness in children with identified Coronavirus infection..

Patients And Methods: Materials and Methods: included the treatment and analysis of the study results of of children (n=68, aged 14.

The modern view of the use of extracorporeal detoxification in the treatment of drug poisoning (overdose).

Objective: Aim: To analyze the results of the application of extracorporeal detoxification methods in the treatment of drug poisoning and their complications..

Patients And Methods: Materials and Methods: The studied data of 129 patients aged 18-46 years with severe drug poisoning treated at the Kyiv toxicological center in 2010-2020.

Complications in gynecological surgeries in Ukraine: results a multicenter study.

Objective: . Aim: To analyze the complications during gynecologic surgery procedures and identify possible risk factors associated with this type of surgery in Ukraine.

Patients And Methods: Materials and Methods: We conducted a multicenter, retrospective cohort study in tertiary care hospitals from 12 regions of Ukraine from January, 2021, to December, 2023.

Indicators of oxidative stress in the organs of the reproductive system of rats under conditions of long-term ethanol exposure.

Objective: . Aim: To investigate changes in oxidative stress indicators in rats under conditions of long-term ethanol exposure.

Patients And Methods: Materials and Methods: We studied the effect of prolonged exposure to ethanol on the activity of free radical processes in the gonads of rats of both sexes.

Sex features of the development of oxidative stress in high and low hypoxic resistancy rats, which experienced repeated stressful episodes of immobilization.

Objective: Aim: of the study was to find out the sexual characteristics of the development of oxidative stress in rats with high and low resistance to hypoxic hypoxia (HRH, LRH) during repeated stressful episodes of immobilization..

Patients And Methods: Materials and Methods: The study was performed on 96 white HRH, LRH male and female Wistar rats.

Experience of endovenous high-frequency electric welding in the treatment of chronic diseases of the lower extremities veins.

Objective: Aim: The purpose was to improve the results of treatment of chronic diseases of the lower extremities veins by using endovenous high-frequency electric welding in automatic mode, and to evaluate the obtained results..

Patients And Methods: Materials and methods: The results of treatment of 146 patients with chronic diseases of the lower extremities veins in the period from 2018 to 2023 were analyzed.