An update on access to novel treatment for metastatic melanoma in Europe - A 2024 survey of the European melanoma registry and the European association of dermato-oncology.

Advances in cancer treatments have significantly improved their effectiveness, yet access to first-line therapies remains limited. A 2017 survey revealed that over 25 % of metastatic melanoma patients in Europe lacked access to recommended therapies. To address this, the European Association of Dermato-Oncology and the European Melanoma Registry conducted a follow-up study on the registration and reimbursement of first-line treatments.

Resilience in the Face of War: a Collaborative Autoethnography of a Ukrainian Refugee Student's Journey through Europe Striving to Find Oneself.

Objective: This study presents the personal experience of a 19-year-old student who fled the war in Ukraine, journeyed across multiple countries, and ultimately enrolled in a university psychology program in Croatia.

Methods: A collaborative autoethnographic approach was employed to explore the student's experience as a war refugee, traversing Europe, and beginning university life in a foreign country. Data were collected through the student's reflective writing.

Development of the process of determining essential hazardous psychosocial factors of employee stress risk.

The purpose of the study is to determine the impact of hazardous psychosocial factors on stress among employees when performing production tasks to develop recommendations for reducing their impact. Based on the recommendations of the ISO 45003:2021 standard, a special questionnaire was developed to determine hazardous psychosocial factors that lead to the appearance of worker's stress, the answers to which were evaluated on a Likert scale with points from 0 to 4. 68 workers (23 men and 45 women) aged 20 to 45 took part in the survey conducted at industrial enterprises of the Dnipro region in May-June 2023.

Cyber warfare: a study of Zelenskyy's social media political performance strategies and effects.

During the Russia-Ukraine war, Ukrainian President Volodymyr Zelenskyy has strategically used social media to appeal for international support. This reflects a broader trend of political figures relying on digital platforms to shape public opinion and influence global narratives during crises. This work uses three main analysis methods, content, sentiment and social network analysis.

Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions.

5-Aminolevulinic acid (5-ALA) is an essential compound in the biosynthesis of heme, playing a critical role in various physiological processes within the human body. This review provides the thorough analysis of the latest research on the molecular mechanisms and potential therapeutic benefits of 5-ALA in managing metabolic disorders. The ability of 5-ALA to influence immune response and inflammation, oxidative/nitrosative stress, antioxidant system, mitochondrial functions, as well as carbohydrate and lipid metabolism, is mediated by molecular mechanisms associated with the suppression of the transcription factor NF-κB signaling pathway, activation of the transcription factor Nrf2/heme oxygenase-1 (HO-1) system leading to the formation of heme-derived reaction products (carbon monoxide, ferrous iron, biliverdin, and bilirubin), which may contribute to HO-1-dependent cytoprotection through antioxidant and immunomodulatory effects.

Earthworm occurrence dataset extracted from Russian-language literature.

Background: Earthworms are one of the most important components of temperate ecosystems and groups of soil animals globally, but data on their distribution around the world are still incomplete and uneven. Northern Eurasia is a region for which available data on earthworm distribution is extremely poor. At the same time, generations of Soviet and Russian researchers have performed extensive research and accumulated a large amount of data on the distribution of earthworms in this vast region.

Global Health and Peace: The Elusive Path with a Focus on Palestine, Ukraine, and Venezuela.

The interrelationality of health and peace is complex, multifactorial, and imbued with political and economic challenges. Peace and health outcomes reflect shared fundamental values related to the achievement of a balanced holistic condition on the individual and collective level. This causal relationship between social inequity and health requires special attention be paid to the impact of political instability and structural violence on undermining health systems in conflict zones.

Renewable energy transition in Europe in the context of renewable energy transition processes in the world. A review.

Both the global and European energy sectors have been undergoing a deep transition for several years, associated with a reduction in the overall share of conventional coal-based energy in favor of new technologies, especially energy from renewable sources (RES). This transition is moving from centralized production towards distributed technologies and from providing only energy to end users towards combining innovative products and services with it. Electricity consumers are becoming prosumers connected to the grid and generating an increasing amount of energy.

Integrating sexual and reproductive health in higher education and healthcare services in Ukraine: A sustainable initiative for empowering war-affected youth.

Integrating Sexual Reproductive Health and Rights (SRHR) into educational programs and healthcare services supports the EU Eastern Partnership and the UN's Agenda 2030. A Swedish Institute (SI)-funded project empowers undergraduate students in medicine, psychology, and social work to support SRHR among youth and young adults in wartime and post-war Ukraine by incorporating the subject into university curricula. In August 2024, a study tour to Sweden was conducted by managers and faculty from Ukrainian universities, during which the visitors to Sweden identified the need to establish Youth Clinics at Ukrainian universities to address the SRHR needs of the war-affected youth population.

[Professor Boksha Vyacheslav Georgievich.].

September 14, 2024 was the 100th anniversary of the birth of a major scientist, specialist in the field of medical climatology, clinical physiology of respiration and circulation, Honored Scientist of the Ukrainian SSR, Doctor of Medical Sciences, Professor Vyacheslav Georgievich Boksha (14.09.1924-22.

[Professor Stanislav Iosofatovich Zalesky - founder of hydrogeochemical and balneological study of natural resources of Siberia].

Stanislav Iosofatovich Zalesky - the first head of the Department of General Medical Chemistry of the Imperial Tomsk University (currently the Department of Chemistry of the Siberian State Medical University), a versatile scientist and public figure, acknowledged expert in medical, chemical, hydrogeological and balneological sciences. Professor S.I.

Chaotic property in general fractional calculus.

We prove the chaos property, in the sense of Devaney, of the discrete-time fractional derivative understood in the framework of general fractional calculus. The latter means the discretization of a differential-convolution operator whose kernel has the Laplace transform belonging to the Stieltjes class.

Synchronization cluster bursting in adaptive oscillator networks.

Adaptive dynamical networks are ubiquitous in real-world systems. This paper aims to explore the synchronization dynamics in networks of adaptive oscillators based on a paradigmatic system of adaptively coupled phase oscillators. Our numerical observations reveal the emergence of synchronization cluster bursting, characterized by periodic transitions between cluster synchronization and global synchronization.

Emotions, Religious Faith, and Coping Strategies of Ukrainians at the Beginning of the 2022 Russo-Ukraine War: A Qualitative Study.

In the early part of the Russo-Ukrainian war, the conflict-affected process indicated a complex array of emotions and that people sought religious faith as a coping strategy. We explore emotions and coping with a qualitative study of 22 Ukrainians at the start of the Russian invasion of February 2022. Ukrainians experienced a range of shifting emotions, including fear and hatred, but also positive emotions such as hope and pride.

Porous Nanocomposite Implants With Gold Nanoparticles for Plastic Surgery.

This study presents an innovative approach to improve implant biointegration and reduce implant-associated infections using porous poly(vinyl formal) nanocomposite matrices incorporated with gold nanoparticles and antimicrobial/anticancer drugs for plastic surgery applications. The porous matrices were characterized using physicochemical techniques and in vitro biochemical assays. The results demonstrated the biocompatibility of PVF nanocomposites and their potential for functionalization with various bioactive molecules and drugs, thereby enhancing their therapeutic efficacy.

Substygophily in Dinaric Karst: A Model Case of Locally Endemic Minnows (Leuciscinae).

The Dinaric Karst extends along the Adriatic coast of the Western Balkan Peninsula and is home to a group of "karst minnows" of the genera , , and , which have adapted to the highly variable water conditions in the karst by spending up to several months underground, but require surface habitats for spawning, defining them as substygophiles. The three species of the genus , , , and , are defined by restricted ranges, making them vulnerable to pollution and extended draughts caused by the climate change. In this study, the phylogeny of Leusciscinae was reconstructed using 15 and one , one , and one complete mitochondrial genomes and the position of the genus within the subfamily as sister species to the clade was confirmed.

Vaccination of pregnant women: an overview of European policies and strategies to promote it.

Maternal immunization is a valuable tool for protecting mother and unborn child from vaccine-preventable diseases. However, the implementation of strategies for vaccinating pregnant women has only recently gained traction. This work is aimed at providing an overview of European vaccination strategies and gathering evidence on interventions enhancing vaccination knowledge, attitudes, and behaviors (KAB) in pregnant women.

Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells.

Many pathogens including viruses enter cells by endocytosis. We identified and evaluated novel endocytosis inhibitors capable of blocking the entry of the HIV-1 Tat protein into neuronal cells and investigated their potential protective properties against Tat-induced neurotoxicity. In this study, the compounds Les-6631 and Les-6633 were synthesized and assessed.

Nosocomial transmission of NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center associated with patients from Ukraine.

We studied nosocomial transmission of multidrug-resistant bla-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center. Whole-genome multilocus sequence typing revealed two genetic clusters consisting of 2 and 5 K. pneumoniae isolates, both from Ukrainian medical evacuees and Dutch patients.

C60 fullerene improves the contractile activity of the injured rat muscle gastrocnemius.

The powerful antioxidant properties of C60 fullerenes have been widely used in biomedical nanotechnology. Owing to the negative effects of free radicals in oxidative stress processes, antioxidants are required to protect injured muscles. Here, the effect of water-soluble C60 fullerenes (daily oral dose 1 mg/kg) on the process of restoration of contractile activity of skeletal muscle of rats (muscle gastrocnemius) 15 days after the initiation of open trauma of different severity was studied for the first time.

A mixed methods exploration of HIV and drug use disclosure in healthcare settings among HIV-positive women who inject drugs in Ukraine.

Disclosing one's HIV status or drug use in healthcare settings has significant implications for public and individual health. It is related to reduced occupational risk of infection for medical providers, improved care, reduction in disease transmission, and other clinical benefits for patients. However, disclosure can be challenging and problematic due to its discrediting aspects.