The effect of succinic acid in liposomal emulsion on the humoral component of the immune system of rats.

Objective: Aim: To investigate the effect of succinic acid on the humoral component of the immune system in rats.

Patients And Methods: Materials and Methods: The study was conducted on two groups of mature non-linear white rats (males) of similar weight (200-270 g, aged 6-8 months), with 5 animals in each group. The control group was fed a standard diet with free access to water throughout the experiment.

Anatomic-biomechanical substantiation of stabilization of the sacroiliac joint in cases of unstable pelvic injuries with a countersink-compression screw.

Objective: Aim: Study the mechanism of interaction between the 'sacroiliac joint - screw' system and determine the optimal parameters of the stabilizing structure, the strength of the system connection through computer modeling, and anatomical-biomechanical experiment.

Patients And Methods: Materials and Methods: The optimal parameters of the stabilizing structure for the sacroiliac joint were calculated using software package MathCAD. To validate the results of the numerical modeling, corresponding investigations of mechanical characteristics and determination of stiffness of the studied systems were conducted by an upgraded testing stand, TIRAtest-2151.

Treatment of chronic wounds of the lower limb with the use of VAC-therapy. Impact on immunity and bacterial films.

Objective: Aim: To improve the results of treatment of patients with chronic wounds of the lower extremities by using complex treatment, including surgical interventions, VAC- therapy, as well as studying the effect of negative pressure on bacterial films of wounds, based on microbiological examination and immune-histochemical data.

Patients And Methods: Materials and Methods: During the period from 2019 to 2023 at the department's clinic, 68 patients with chronic wounds of the lower extremities were examined and treated. These are mainly women (n=63) aged from 35 to 80 years.

Change of the anterior talus-fibular ligament length of asymptomatic patients during inversion stress test.

Objective: Aim: To study the ATFL length among asymptomatic population of young patients on both joints by using the method of ultrasound examination of the ankle joint and applying the inversion stress test.

Patients And Methods: Materials and Methods: the length of the ATFL was measured among 60 boys and 60 girls during the research. Sonography was performed on both joints, in each of the two studied positions, three times per position in order to obtain the average ligament length.

Heart rate and blood pressure in soccer players differing in sports qualification.

Objective: Aim: To investigate the effects of exercise training on heart rate and blood pressure in soccer players of different skill levels.

Patients And Methods: Materials and Methods: 693 soccer players with different sports qualifications were studied. Heart rate (HR) and blood pressure (BP) were measured at rest at the beginning of the preparatory phase of the training cycle.

Biomarkers of inflomation in the blood of patients with the degenerative lumbar spine disease and complications after transpedicular fixation.

Objective: Aim: To investigate the peculiarities of deviations of preoperative values of biochemical markers of inflammation in the blood serum of patients with degenerative diseases of the lumbar spine after transpedicular fixation, with a complicated postoperative course to predict the development of various postoperative complications.

Patients And Methods: Materials and Methods: The content of glycoproteins (GP), sialic acids (SA), C-reactive protein (CRP), seroglicoids (SG), haptoglobin (HG), Veltman`s test (VT) were investigated. The results are comparable by the Student-Fisher method.

Evaluation of the clinical effectiveness of conservative (pre-surgical) treatment schemes for generalized periodontitis in patients with various somatic pathologies.

Objective: Aim: Optimization of conservative treatment schemes for generalized periodontitis (GP) against the background of somatic pathology, depending on the indicators of the Community Periodontal Index of Treatment Needs (CPITN).

Patients And Methods: Materials and Methods: CPITN was performed in 134 patients with GP against the background of various somatic pathologies and divided into main and comparison subgroups. Treatment scheme No.

Woman's self-realization in the system and structure of family relations.

Objective: Aim: To study the peculiarities of self-realization of women with different states of family interaction, to build a mathematical model that allows to identify the probability of self-realization of women, depending on their psycho-emotional, individual-psychological, behavioral and partnership patterns, to consider the family as a whole system, to define the phenomenon of family interaction as a leading the construct of the process of family functioning, to distinguish levels of family crisis and states of family interaction.

Patients And Methods: Materials and Methods: Women of different social status and level of self-realization participated in this study.

Results: Results: In the given sample, it was displayed what percentages of divorced women compared to those living in families are self-actualized in their lives.

Small common bile duct - the risk factor for post-ERCP pancreatitis in patients with choledocholithiasis.

Objective: Aim: To investigate the risk factors for PEP in patients with choledocholithiasis.

Patients And Methods: Materials and Methods: We have retrospectively analyzed 253 cases with choledocholithiasis that underwent ERCP. The primary endpoint was the occurrence of PEP.

Preliminary study of the influence of maternal and neonatal NOS3 (rs1799983), IL1B (rs1143634) genes variants and their intergenic interaction on the development of hypoxic-ischemic encephalopathy in newborns in the context of treatment planning.

Objective: Aim: To determine the influence of maternal and neonatal variants of the eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) genes and their intergenic interactions on the development of HIE in newborns.

Patients And Methods: Materials and Methods: The study included a cohort of 105 newborns and their 99 mothers. Determination of variants of the genes eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) was carried out for the patients of study groups.

Photoregulation of the biosynthetic activity of fungus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation.

This article presents new data on the integrated use of colloidal solutions of nanoparticles and low-intensity laser radiation on the biosynthetic activity of the medicinal mushroom . Traditional mycological methods, colloidal solutions of biogenic metals, and unique photobiological methods have also been used. It was found that colloidal solutions of nanoparticles of all metals used increased the growth characteristics of (55-60%), while irradiation of the fungal inoculum with laser light in a medium with nanoparticles reduced the growth activity of mycelia by 12.

Measurement of multidifferential cross sections for dijet production in proton-proton collisions at .

A measurement of the dijet production cross section is reported based on proton-proton collision data collected in 2016 at by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of up to 36.3 . Jets are reconstructed with the anti- algorithm for distance parameters of and 0.

Anticancer Attributes and Multifaceted Pharmacological Implications of Laetrile and Amygdalin.

Laetrile, known as vitamin B17, is often used interchangeably with amygdalin. Laetrile is a semi-synthesis product of amygdalin, whereas amygdalin is a naturally occurring substance in many plants. Both compounds have a nitrile functional group that, when activated by the intestinal enzyme β-glucosidases, releases hydrogen cyanide.

Peculiarities of cardio-respiratory relationships in qualified athletes with different types of heart rhythm regulation according to respiratory maneuver data.

Introduction: Our goal was to determine the differences in changes in cardiovascular and cardiorespiratory interaction indicators during a respiratory maneuver with a change in breathing rate in athletes with different types of heart rate regulation.

Methods: The results of a study of 183 healthy men aged 21.2 ± 2.

Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity.

Introduction: Marie-Unna hereditary hypotrichosis (MUHH) is an autosomal dominant disorder characterized by a specific pattern of hair loss. Initially described in 1925 by Marie-Unna in a German family spanning over seven generations, MUHH represents a previously unidentified form of congenital hypotrichosis. It typically presents as sparse hair at birth with a coarse texture, followed by regrowth during childhood then, finally, gradual hair loss at puberty, resembling pattern of androgenetic alopecia.

Mental Health Assessment of the Population: Study Protocol of the MAP Research Program in Ukraine (MAP-U) and in Zurich (MAP-Z).

Objectives: To conduct mental health surveillance in adults in Ukraine and Ukrainian refugees (Canton of Zurich, Switzerland) as an actionable scientific foundation for public mental health and mental healthcare.

Methods: Mental Health Assessment of the Population (MAP) is a research program including prospective, population-based, digital cohort studies focused on mental health monitoring. The study aims to include 17,400 people from the general population of Ukraine, 1,220 Ukrainians with refugee status S residing in the canton of Zurich, and 1,740 people from the Zurich general population.

Advancements in Artificial Intelligence in Noninvasive Cardiac Imaging: A Comprehensive Review.

Background: Technological advancements in artificial intelligence (AI) are redefining cardiac imaging by providing advanced tools for analyzing complex health data. AI is increasingly applied across various imaging modalities, including echocardiography, magnetic resonance imaging (MRI), computed tomography (CT), and nuclear imaging, to enhance diagnostic workflows and improve patient outcomes.

Hypothesis: Integrating AI into cardiac imaging enhances image quality, accelerates processing times, and improves diagnostic accuracy, enabling timely and personalized interventions that lead to better health outcomes.

Maternal cell-free DNA in early pregnancy for preeclampsia screening: a systematic review.

Purpose: To quantify the separation between maternal blood cell-free (cf)DNA markers in preeclampsia and unaffected pregnancies and compare with existing markers. This approach has not been used in previous studies.

Methods: Comprehensive systematic literature search of PubMed to identify studies measuring total cfDNA, fetal cf(f)DNA or the fetal fraction (FF) in pregnant women.

New Layered Boride NiPtB ( = 0.5) with a Ternary Derivative Structure of MoB.

A novel ternary boride, NiPtB ( = 0.5), was obtained by argon-arc melting of the elements followed by annealing at 750 °C. It exhibits a new structure type with the space group ( = 2.

Empathy During Crises: Investigating Attitudes, Tolerance, and Ingroup-Outgroup Dynamics in Response to Refugee Movements.

Objective: In times of societal crises, it is pivotal to understand and share others' feelings. Yet, the role of empathy in fostering prosocial responses during societal crises has not gained enough attention. Our study uses the onset of Russia's war on Ukraine to examine three key questions: (1) Is empathy related to attitudes toward pro-refugee policies? (2) Does empathy correlate with a higher tolerance for diverse opinions on refugee policies? (3) Is empathy linked to perceived interpersonal closeness toward social in- and outgroups, including refugees?

Methods And Results: Using observational data from online surveys conducted with a largely representative quota sample from Germany (N = 1199-1631) during the initial months of the war, we found that empathy was associated with significantly higher support of pro-refugee policies, driven primarily by empathic concern.

Alternative Role of B/b Knob-Hole Interactions in the Fibrin Assembly.

The self-assembly of fibrin is a vital process in blood clotting, primarily facilitated by the interactions between knobs "A" and "B" in the central E region of one molecule and the corresponding holes "a" and "b" in the peripheral D regions of two other fibrin molecules. However, the precise function of the interactions between knob "B" and hole "b" during fibrin polymerization remains a subject of ongoing debate. The present study focuses on investigating intermolecular interactions between knob "B" and hole "b".

Environmental impacts of restructuring the EU's natural gas supply and consumption: Learnings from the 2022 energy crisis.

In 2022, the European Union put forward the REPowerEU plan in response to Russia's invasion of Ukraine, aiming at enhancing short-term energy security by diversifying imports and reducing natural gas demand while accelerating the deployment of renewable alternatives in the long term. Here, we quantify the life cycle environmental impacts of both REPowerEU's short-term measures, including the controversial extended coal-fired power plant operations, and how the first year of the crisis was managed in practice. We find that the policy measures' impact on greenhouse gas (GHG) emissions would be negligible, although they could have detrimental effects on other environmental categories.

Devonian-Mississippian magmatism related to extensional collapse in Svalbard: implications for radiating dyke swarms.

Background: Despite extensive studies of the Mesozoic-Cenozoic magmatic history of Svalbard, little has been done on the Paleozoic magmatism due to fewer available outcrops.

Methods: 2D seismic reflection data were used to study magmatic intrusions in the subsurface of eastern Svalbard.

Results: This work presents seismic evidence for west-dipping, Middle Devonian-Mississippian sills in eastern Spitsbergen, Svalbard.

Primordial black holes and their gravitational-wave signatures.

In the recent years, primordial black holes (PBHs) have emerged as one of the most interesting and hotly debated topics in cosmology. Among other possibilities, PBHs could explain both some of the signals from binary black hole mergers observed in gravitational-wave detectors and an important component of the dark matter in the Universe. Significant progress has been achieved both on the theory side and from the point of view of observations, including new models and more accurate calculations of PBH formation, evolution, clustering, merger rates, as well as new astrophysical and cosmological probes.

Efficacy of Cevimeline on Xerostomia in Sjögren's Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Background: Xerostomia, or dry mouth, is a common and debilitating symptom in patients with Sjögren's syndrome, affecting their quality of life. Although Cevimeline, a muscarinic agonist, has been investigated as a potential treatment, its efficacy and optimal dosage remain uncertain. This study aims to assess the effectiveness of Cevimeline in relieving xerostomia in patients with Sjögren's syndrome by a meta-analysis of randomized clinical trials (RCT).