Antioxidant System Activity in Roots and Shoots of Bean Cultivars in Response to Seed Treatment with Auxin as a Potential Model of Interaction with Endophytic Bacteria.

Plant growth-promoting endophytic bacteria (PGPEB), producing auxins, are offered for a promising eco-friendly crop production. Precise bacterial strain selection is essential to ensure consistent and effective plant growth and resilience. Creating a model for the optimal dose-dependent interactions between PGPEB and hosts is necessary for understanding the mechanisms of high-precision selection of the inoculant composition to enhance bacterial preparations' efficacy.

[Pharmacogenomic and pharmacometabolomic biomarkers of the efficacy and safety of antidepressants: focus on selective serotonin reuptake inhibitors].

The efficacy and safety of psychopharmacotherapy with antidepressants is of great medical importance. The search for clinical and biological predictors for choosing the optimal psychopharmacotherapy with antidepressants is actively underway all over the world. Research is mainly devoted to searching for associations of polymorphic gene variants with the efficacy and safety of therapy.

Predicting Field Effectiveness of Endophytic Inoculants for Common Bean Using Morphometric and Biochemical Markers.

According to four field experiments, after the inoculation of L. cultivar Ufimskaya with the commercial strain 26D and the promising strain 10-4, it was found that inoculation with 10-4 improved seed productivity (SP) by 31-41% per plant, but only in dry years. In contrast, all 4 years of inoculation with 26D were ineffective or neutral.

Novel binuclear copper(II) complexes with sulfanylpyrazole ligands: synthesis, crystal structure, fungicidal, cytostatic, and cytotoxic activity.

New binuclear copper(II) [Cu(II)] tetraligand complexes (six examples) with sulfanylpyrazole ligands were synthesized. Electron spin resonance (ESR) studies have shown that in solution the complexes are transformed to the mononuclear one. Fungicidal properties against Candida albicans were found for the Cu complexes with benzyl and phenyl substituents.

Gene pool preservation across time and space In Mongolian-speaking Oirats.

The Oirats are a group of Mongolian-speaking peoples residing in Russia, China, and Mongolia, who speak Oirat dialects of the Mongolian language. Migrations of nomadic ethnopolitical formations of the Oirats across the Eurasian Steppe during the Late Middle Ages/early Modern times resulted in a wide geographic spread of Oirat ethnic groups from present-day northwestern China in East Asia to the Lower Volga region in Eastern Europe. In this study, we generate new genome-wide and mitochondrial DNA data for present-day Oirat-speaking populations from Kalmykia in Eastern Europe, Western Mongolia, and the Xinjiang region of China, as well as Issyk-Kul Sart-Kalmaks from Central Asia, and historically related ethnic groups from Altai, Tuva, and Northern Mongolia to study the genetic structure and history of the Oirats.

The Nitro Group Reshapes the Effects of Pyrido[3,4-]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells.

Serine-threonine protein kinases of the DYRK and CLK families regulate a variety of vital cellular functions. In particular, these enzymes phosphorylate proteins involved in pre-mRNA splicing. Targeting splicing with pharmacological DYRK/CLK inhibitors emerged as a promising anticancer strategy.

New Triphenylphosphonium Salts of Spiropyrans: Synthesis and Photochromic Properties.

The most important area of modern pharmacology is the targeted delivery of drugs, and one of the most promising classes of chemical compounds for creating drugs of this kind are the photochromic spiropyrans, capable of light-controlled biological activity. This work is devoted to the synthesis and study of the photochromic properties of new triphenylphosphonium salts of spiropyrans. It was found that all the synthesized cationic spiropyrans have high photosensitivity, increased resistance to photodegradation and the ability for photoluminescence.

Diversity of Arbuscular Mycorrhizal Fungi in Distinct Ecosystems of the North Caucasus, a Temperate Biodiversity Hotspot.

Background: Investigations that are focused on arbuscular mycorrhizal fungus (AMF) biodiversity is still limited. The analysis of the AMF taxa in the North Caucasus, a temperate biodiversity hotspot, used to be limited to the genus level. This study aimed to define the AMF biodiversity at the species level in the North Caucasus biotopes.

Hormonal Status of Transgenic Birch with a Pine Glutamine Synthetase Gene during Rooting In Vitro and Budburst Outdoors.

Improving nitrogen use efficiency (NUE) is one of the main ways of increasing plant productivity through genetic engineering. The modification of nitrogen (N) metabolism can affect the hormonal content, but in transgenic plants, this aspect has not been sufficiently studied. Transgenic birch () plants with the pine glutamine synthetase gene were evaluated for hormone levels during rooting in vitro and budburst under outdoor conditions.

Treatment of Metastatic Renal Cell Carcinoma with Checkpoint Inhibitors in Clinical Practice in the Volga-Ural Region of the Eurasian Continent.

Introduction: Renal cancer ranks 10 in the mortality structure of the Russian Federation. The introduction of checkpoint inhibitors has changed the paradigm of treatment of patients with malignant neoplasms.

Method: Data from clinical trials have shown good progression-free median and median overall survival.

Single-Bubble Sonoluminescence of Colloidal Suspensions of Europium(II) Salt Nanoparticles.

Colloidal suspensions of EuCl, EuBr, and EuSO nanoparticles (<50 nm) in dodecane and EuSO in 70% HSO were synthesized. Moving single-bubble sonoluminescence (m-SBSL) spectra were obtained for a bubble performing radial oscillations in these suspensions and translational motions at the antinode of a standing ultrasonic wave with a frequency of about 27 kHz. In these spectra (at a spectral resolution of 10 nm), the sono-excited luminescence bands of the Eu ion were detected for the first time, coinciding in the shape and position of the maxima (404, 413, and 377 nm for EuCl, EuBr, and EuSO, respectively) with the bands of Eu located in a crystalline environment in the photoluminescence spectra of nanoparticles of europium salts in suspensions.

[The characteristics and problems of professional activity of medical workers in conditions of COVID-19 pandemic].

The article is based on the results of sociological survey of medical workers of the Republic of Bashkortostan in 2021. The approaches to issues of their professional activities are analyzed. It is argued that the COVID-19 pandemic has aggravated a number of systemic problems accumulated in health care system in last years.

Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers.

Epidemiological data highlight prostate cancer as a significant global health issue, with high incidence and substantial impact on patients' quality of life. The prevalence of this disease is associated with various factors, including age, heredity, and race. Recent research in prostate cancer genetics has identified several genetic variants that may be associated with an increased risk of developing the disease.

Genetic methods in honey bee breeding.

The honey bee Apis mellifera is a rather difficult object for selection due to the peculiarities of its biology. Breeding activities in beekeeping are aimed at obtaining bee colonies with high rates of economically useful traits, such as productivity, resistance to low temperatures and diseases, hygienic behavior, oviposition of the queen, etc. With two apiaries specializing in the breeding of A.

Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis.

Discovery of molecular mechanisms of primary osteoporosis development is fundamental to understand the pathogenesis of musculoskeletal diseases in general and for identifying key links in the genetic and epigenetic regulation of bone remodelling genes. The number of identified molecular genetic markers for osteoporosis is increasing but there is a need to describe their functional interactions. These interactions have been determined to be associated with the control of expression of a number of transcription factors and the differentiation of mesenchymal stem cells through the pathway of osteoblastogenesis or adipogenesis, and monocytic precursors through the pathway of osteoclastogenesis.

Effect of Plastic Deformation on the Structure and Mechanical Properties of the Zn-4Ag-1Cu Zinc Alloy.

It is known that zinc biodegradable alloys are a promising material for producing biomedical implants for orthopedics and vascular stents. Among them, the Zn-Ag-Cu zinc alloy is of special interest due to the antibacterial and antimicrobial properties of Ag and Cu. To improve the mechanical properties of the Zn-4Ag-1Cu zinc alloy, the effect of equal-channel angular pressing (ECAP) on the microstructure and strength has been investigated.

Design of silicone interfaces with antibacterial properties.

Silicone implants are widely used for plastic or reconstruction medical applications. However, they can cause severe infections of inner tissues due to bacterial adhesion and biofilm growth on implant surfaces. The development of new antibacterial nanostructured surfaces can be considered as the most promising strategy to deal with this problem.

Comprehensive Study of the Mechanism of the "Aromatic Nitroso Oxide-Olefin" Interaction as a Function of the Reagents' Structure.

Using reaction model systems (nitroso oxide ArNOO, Ar = MeNCH or ONCH; exhaustive set of methyl- and cyano-substituted ethylenes), a detailed study of the reaction mechanism of ArNOO with unsaturated compounds was carried out using the density functional theory (M06L/6311 + G(d,p)). The reaction is preceded by the formation of a reagent complex of stacking type, which is favorable for further transformation. Depending on the structure of alkene, the reaction may proceed two extreme mechanisms: synchronous (3 + 2)-cycloaddition (the most typical case) or one-center nucleophilic attack of the terminal oxygen atom of ArNOO on the less substituted carbon atom of the double bond.

Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan.

About 5-10% of all ovarian cancer cases show familial clustering, and some 15-25% of familial ovarian cancer cases are mediated by high-penetrance mutations in the BRCA1 and BRCA2 genes. Only few other genes have been identified for familial ovarian cancer.We conducted targeted next-generation sequencing of the protein coding region of 21 candidate genes, including UTR regions, in genomic DNA samples of 48 patients with familial ovarian cancer from the Republic of Bashkortostan.

COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments.

The novel coronavirus infection (COVID-19) causes a severe acute illness with the development of respiratory distress syndrome in some cases. COVID-19 is a global problem of mankind to this day. Among its most important aspects that require in-depth study are pathogenesis and molecular changes in severe forms of the disease.

Whole Exome Sequencing Study Suggests an Impact of , and Genes on Diffuse Gastric Cancer Development.

Gastric cancer (GC) is one of the most common cancer types in the world with a high mortality rate. Hereditary predisposition for GC is not fully elucidated so far. The aim of this study was identification of possible new candidate genes, associated with the increased risk of gastric cancer development.

Photochromic and Luminescent Properties of a Salt of a Hybrid Molecule Based on C Fullerene and Spiropyran-A Promising Approach to the Creation of Anticancer Drugs.

For the first time a pyrrolidinofullerene salt containing a spiropyran group and an ammonium group, capable of reversibly reacting to UV radiation, has been synthesized. Photoinduced reactions of the synthesized compounds were studied using absorption and luminescence spectroscopies, spectral and kinetic characteristics were measured. The hybrid molecule was found to exhibit intrinsic fluorescence even in the spirocyclic form.

[The impact of social economic factors and family dietary intake on health of children and adolescents].

The impact of social economic factors, digitalization, sanctions and quality of family diet is manifested in increasing effect of these factors on lifestyle, environment and health of children and adolescents. The surrounding reality affects their organism in formative way due to digitalization of various areas of activity. The consequences of pandemic, announced new sanctions of Western countries, environmental pollution and digitalization of life result in deterioration of life conditions and population health.

Synthesis, Photochromic and Luminescent Properties of Ammonium Salts of Spiropyrans.

New salts of photochromic indoline spiropyrans capable of reversibly responding to UV radiation were synthesized to develop light-controlled materials. Photoinduced reactions of the synthesized compounds were studied using absorption and luminescence spectroscopies, and the quantum yields of photoisomerization and other spectral and kinetic characteristics were measured. It was shown that the light sensitivity and photostability of the synthesized compounds are considerably influenced by the length of the spacer between the indole and ammonium nitrogen atoms.