Survival Analysis of Anaplastic Thyroid Carcinoma With Various Therapeutic Modalities: Twenty-Seven Years' Experience in a Single Cancer Center.

Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid gland malignancy. Several consensuses support the concept of multimodal therapy that combines surgery, radiation, chemotherapy, and targeted therapy. However, patient's comorbidity, poor performance status, and metastasis often make it impossible for patients to undergo multimodal therapy.

An S100A8/A9 neutralizing antibody potently ameliorates contact hypersensitivity and atopic dermatitis symptoms.

Contact hypersensitivity (CHS) and atopic dermatitis (AD) are pervasive inflammatory skin diseases with similar symptoms, and the global prevalence of both conditions is steadily rising. Many compounds and biotics have been developed to target molecules critical to the etiology or pathogenesis of CHS and AD. However, such molecules are sometimes ineffective or lose potency over the therapeutic course.

Intracranial neurenteric cyst in the cerebellopontine angle: a case report.

Neurenteric cysts, rare benign tumors, are most often found in the cervical or thoracic spinal cord, with intracranial occurrences being extremely uncommon. This case report describes a 52-year-old female with a neurenteric cyst in the cerebellopontine angle, presenting with headaches and balance disturbances. Magnetic resonance imaging (MRI) revealed a cystic lesion causing hydrocephalus, and surgical removal was performed using a retrosigmoid approach.

High levels of soluble P-selectin, neutrophil extracellular traps, and myeloperoxidase as risk factor of deep vein thrombosis in malignancy patients receiving platinum-based chemotherapy.

Backgrounds: Venous Thromboembolism (VTE) is a disease entity comprising Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). VTE events increase the mortality rate of patients with cancer receiving platinum-based chemotherapy. Soluble P-Selectin, Neutrophil Extracellular Traps (NET), and myeloperoxidase (MPO) are risk factors associated with DVT in malignancy patients receiving platinum-based chemotherapy.

Probiotics Supplementation for Improving Glucolipid Parameters in Individuals with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Trials.

The absence of suitable intervention significantly increases the likelihood of type 2 diabetes mellitus (T2DM) development in people with prediabetes. Recent statistical findings indicate that the gut microbiome might influences the development of insulin resistance. The objective of our study was to assess the efficacy and safety of probiotic supplementation in individuals diagnosed with prediabetes.

Surgical Outcomes of Lateral Ulnar Collateral Ligament Reconstruction Versus Repair for Posterolateral Rotatory Instability of the Elbow: A Systematic Review and Meta-analysis.

Background: The aim of surgical treatment for posterolateral rotatory instability (PLRI) of the elbow is to restore the integrity of the lateral ulnar collateral ligament (LUCL), with ligamentous reconstruction being the preferred option for recurrent symptomatic PLRI. However, there is no clinical evidence demonstrating the superiority of reconstruction versus repair. Treatment options currently depend on the cause of the LUCL injury and surgeon preference.

Seeking and encountering online information for menstrual health: a qualitative study among adolescent schoolgirls in Gianyar Regency and Denpasar City, Bali, Indonesia.

Sufficient and accurate information is a requirement for menstrual health and supports adolescents in realising their human rights. As mobile connectivity increases globally, many young people may seek or encounter menstrual health information online through web-based platforms, social media, or health apps. Despite the relevance of online information, menstrual health research and programming have focused on formal and school-based learning.

Formal Security Reassessment of the 5G-AKA-FS Protocol: Methodological Corrections and Augmented Verification Techniques.

The 5G-AKA protocol, a foundational component for 5G network authentication, has been found vulnerable to various security threats, including linkability attacks that compromise user privacy. To address these vulnerabilities, we previously proposed the 5G-AKA-Forward Secrecy (5G-AKA-FS) protocol, which introduces an ephemeral key pair within the home network (HN) to support forward secrecy and prevent linkability attacks. However, a re-evaluation uncovered minor errors in the initial BAN-logic verification and highlighted the need for more rigorous security validation using formal methods.

Correlation of CD44 Protein Expression with Larger Tumor Size and Advanced Stage of Breast Cancer Patients.

Objectives: This study aimed to determine the expression of CD44 in breast cancer and its association with patients' clinicopathological data, particularly in Bali.

Material And Methods: This was a cross-sectional study in the Integrated Biomedical Laboratory and Biochemistry Laboratory of the Faculty of Medicine Udayana University, during January-December 2022, which lasted 12 months with 46 samples.

Results: The study showed that the age range of our subjects was 38-86 years old, with the majority of the parity being less than three.

Global knowledge flows and the psychiatric encounter in Indonesia.

In this article, we examine the clinical encounters of people diagnosed with a severe mental illness (SMI). Drawing on more than 1-year of ethnographic research and interviews in Indonesia, we show that instances of moral self-reflection occurring in the process of acquiring and appropriating clinical insight emerge at the intersection of heterogeneous discursive regimes. When biomedical notions of health and illness dominate these discourses, they reimagine pre-existing notions about spirituality and religion.

Ecytonucleospora hepatopenaei (EHP) disease prevalence and mortality in Litopenaeus vannamei: a comparative study from Eastern India shrimp farms.

Ecytonucleospora hepatopenaei (EHP), a microsporidian parasite first named and characterized from the Penaeus monodon (black or giant tiger shrimp), causes growth retardation and poses a significant threat to shrimp farming. We observed shrimp farms associated with disease conditions during our fish disease surveillance and health management program in West Bengal, India. Shrimp exhibited growth retardation and increased size variability, particularly in advanced stages, exhibiting soft shells, lethargy, reduced feeding and empty midguts.

Total Elbow Arthroplasty as the Treatment of Choice for a Young Man with Neglected Terrible Triad of the Elbow Joint and Schizophrenia: A Case Report.

In young patients, the use of total elbow arthroplasty (TEA) is rarely preferred due to its high rate of mechanical failure. Poor compliance and psychological problems encountered may lead to increased difficulty in management. A 38-year-old male complained stiffness and pain on his left elbow.

Empowering Deaf Children Through KatakLarita in Sexual Safety Education.

In the depth topic of child protection, the alarming prevalence of sexual violence remains a dark thread that permeates every layer of society. This report delves into the implementation of "KatakLarita," an innovative and inclusive educational initiative aimed at enhancing sexual safety education for deaf children. Results showed that using "KatakLarita" as learning media helped deaf students improve significantly in sexual safety knowledge.

Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia.

Background: Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insulin-like growth factor 1 (IGF-1). Increased cancer risk is also associated with increased adipose tissue, such as in abdominal obesity, due to the higher risk of insulin resistance and hyperinsulinemia.

A Novel Scoring System for Assessing In-Hospital Mortality Risk in Patients With Liver Cirrhosis.

Background Mortality among patients with liver cirrhosis has recently increased in Indonesia. However, predicting the prognosis of patients hospitalized with liver cirrhosis remains a clinical challenge due to its variability and dependence on multiple factors. A simple and accurate method is required to identify high-risk patients.

Minimizing food oxidation using aromatic polymer: From lignin into nano-lignin.

Food loss and waste caused by oxidation result in environmental and economic losses and health threats. Lignin is an abundant aromatic polymer with varied antioxidant capacity, which can reduce food oxidation caused by radical species exposure. The lignin antioxidant strength can be influenced by source, type, structure, processing, degradation products, chemical modifications, and particle size.

Effect of preventive chemotherapy for neglected tropical diseases in Indonesia from 1992 to 2022: A systematic review and meta-analysis.

Objectives: This study aimed to describe the prevalence of lymphatic filariasis (LF), soil-transmitted helminthiasis (STH) and schistosomiasis (SC) in Indonesia before and after PC implementation through a systematic review and meta-analysis.

Methods: Embase, MEDLINE, PubMed, Scopus, Web of Science and Google Scholar were searched for articles published between 1 January 1992 and 31 December 2022, reporting LF, STH and SC in Indonesia. Using the Ministry of Health lists of districts receiving PC programs, we identified whether data collection was conducted before or after PC implementation in that particular district.

Effectiveness and safety of mineralocorticoid receptor antagonists in heart failure patients with and without diabetes: a systematic review and meta-analysis.

Background: Mineralocorticoid receptor antagonists (MRAs) have been shown to improve outcomes in various populations of heart failure (HF) patients. However, the impact of concomitant diseases, such as diabetes mellitus (DM), on these outcomes remains unclear. This meta-analysis aimed to evaluate the efficacy and safety of MRAs in heart failure patients with and without diabetes mellitus.

Occipital Vascularized Bone Graft for Reconstruction of a C3-C7 Defect.

The number of spinal reconstruction cases is growing, as are the accompanying complications. Wound complications after spinal reconstruction can be fatal and can affect up to 19% of patients undergoing major spine surgery. The discipline of spinoplastic surgery is characterized by the use of vascularized bone grafts to reconstruct spinal defects, which provide better results compared with nonvascularized and allogenic equivalents, owing to their superior blood supply.

Radiomic Features as Artificial Intelligence Prognostic Models in Glioblastoma: A Systematic Review and Meta-Analysis.

Background: Glioblastoma, the predominant primary tumor among all central nervous systems, accounts for around 80% of cases. Prognosis in neuro-oncology involves assessing the disease's progression in different individuals, considering the time between the initial pathological diagnosis and the time until the disease worsens. A noninvasive therapeutic approach called radiomic features (RFs), which involves the application of artificial intelligence in MRI, has been developed to address this issue.

Exploring the Role of Nurses in Travel Medicine to Improve Service Performance in Travelers: A Systematic Review.

Nurses play an important role in travel medicine. However, information about the role of nurses in travel medicine is still limited. This systematic literature review is aimed to exploring the role of nurses in travel medicine to improve service performance in travelers.