11 results match your criteria: "USC Diabetes and Obesity Research Institute.[Affiliation]"
Objective: The relationship between cortisol and perceived stress is poorly understood. We sought to determine whether perceived stress is associated with cortisol biomarkers in adolescents.
Methods: We examined 229 adolescents (mean age = 15.
Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population.
Diabetes Care
August 2024
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Objective: While most genetic variants of type 2 diabetes (T2D) are suggested to be associated with β-cell dysfunction cross sectionally, their association with the longitudinal change of β-cell function remains largely unknown.
Research Design And Methods: We analyzed data from 6,311 participants without T2D at baseline (mean [SD] age 51.6 [8.
A saturated map of common genetic variants associated with human height.
Nature
October 2022
Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Article Synopsis
- Common SNPs may account for 40-50% of human height variation, and this study identifies 12,111 SNPs linked to height from a large sample of 5.4 million individuals.
- These SNPs cluster in 7,209 genomic segments, encompassing about 21% of the genome and showing varying densities enriched in relevant genes.
- While these SNPs explain a substantial portion of height variance in European populations (40-45%), their predictive power is lower (10-24%) in other ancestries, suggesting a need for more research to enhance understanding in diverse populations.
Mind- and Body-Based Interventions Improve Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
J Integr Complement Med
February 2023
Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Only 51% of patients with type 2 diabetes achieve the hemoglobin A1c (HbA1c) <7% target. Mind and body practices have been increasingly used to improve glycemic control among patients with type 2 diabetes, but studies show inconsistent efficacy. The authors conducted a systematic review and meta-analysis to assess the association between mind and body practices, and mean change in HbA1c and fasting blood glucose (FBG) in patients with type 2 diabetes.
View Article and Find Full Text PDFPublisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Nat Commun
February 2021
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Nat Commun
January 2021
Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Article Synopsis
- * A large study involving over 150,000 individuals found that genetic effects on fasting insulin vary by sex, specifically at the IRS1 and ZNF12 gene locations, with women showing higher RNA expression levels for ZNF12.
- * The findings highlight that fasting insulin in women correlates more strongly with certain conditions like waist-to-hip ratio and anorexia nervosa, indicating that metabolic health differences between sexes may provide insight into their respective genetic influences.
Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach.
Prostaglandins Other Lipid Mediat
June 2020
Department of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, United States; USC Diabetes and Obesity Research Institute, Los Angeles, CA United States. Electronic address:
Soluble epoxide hydrolase (sEH) converts several FFA epoxides to corresponding diols. As many as 15 FFA epoxide-diol ratios are measured to infer sEH activity from their ratios. Using previous data, we assessed if individual epoxide-diol ratios all behave similarly to reflect changes in sEH activity, and whether analyzing these ratios together increases the power to detect changes in in-vivo sEH activity.
View Article and Find Full Text PDFRe-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases.
Curr Diab Rep
September 2017
Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Thalians E103, Los Angeles, CA, 90048, USA.
Purpose Of Review: The purpose of the review was to revisit the possibility of the endocannabinoid system being a therapeutic target for the treatment of obesity by focusing on the peripheral roles in regulating appetite and energy metabolism.
Recent Findings: Previous studies with the global cannabinoid receptor blocker rimonabant, which has both central and peripheral properties, showed that this drug has beneficial effects on cardiometabolic function but severe adverse psychiatric side effects. Consequently, focus has shifted to peripherally restricted cannabinoid 1 (CB1) receptor blockers as possible therapeutic agents that mitigate or eliminate the untoward effects in the central nervous system.
An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
Endocrinology
September 2015
Department of Medicine (P.R.S., E.A.D., J.W.R., C.S.N.), Center for Public Health Genomics (A.J.M., S.S.R.), and Department of Chemistry (E.A.D.), University of Virginia, Charlottesville, Virginia 22904; Department of Biochemistry (N.D.P.), Center for Genomics and Personalized Medicine Research (N.D.P.), Center for Diabetes Research (N.D.P.), Center for Public Health Genomics (C.D.L., N.D.P., L.E.W.), Department of Biostatistical Sciences (C.D.L.), and Division of Public Health Sciences (L.E.W.), Wake Forest School of Medicine, Winston-Salem, North Carolina 27157; Department of Physiology and Biophysics (R.M.W.), Department of Preventive Medicine, and USC Diabetes and Obesity Research Institute (R.M.W.), Keck School of Medicine of University of Southern California, Los Angeles, California 90033; and Institute for Translational Genomics and Population Sciences (K.D.T.) and Department of Pediatrics (K.D.T.), Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502.
Genome-wide association studies in human type 2 diabetes (T2D) have renewed interest in the pancreatic islet as a contributor to T2D risk. Chronic low-grade inflammation resulting from obesity is a risk factor for T2D and a possible trigger of β-cell failure. In this study, microarray data were collected from mouse islets after overnight treatment with cytokines at concentrations consistent with the chronic low-grade inflammation in T2D.
View Article and Find Full Text PDFResponse to 'Energy balance measurement: when something is not better than nothing'.
Int J Obes (Lond)
July 2015
Nutrition Obesity Research Center, The University of Alabama at Birmingham, Birmingham, AL, USA.
Variation in PPARG is associated with longitudinal change in insulin resistance in Mexican Americans at risk for type 2 diabetes.
J Clin Endocrinol Metab
March 2015
Department of Research & Evaluation (M.H.B., J.W., M.T., J.M.L., A.H.X.), Kaiser Permanente Southern California, Pasadena, California; Department of Preventive Medicine (N.W., R.M.W., T.A.B.), Keck School of Medicine of University of Southern California (USC), Los Angeles, California; Medical Genetics Institute (K.D.T., T.H.), Cedars-Sinai Medical Center, Los Angeles, California; Department of Medicine (E.T.), Keck School of Medicine of USC, Los Angeles, California; USC Diabetes and Obesity Research Institute (R.M.W., T.A.B.), Los Angeles, California; Department of Physiology & Biophysics (R.M.W., T.A.B.), Keck School of Medicine of USC, Los Angeles, California.
Context: Peroxisome proliferator-activated receptor gamma (PPARG) is a susceptibility locus for type 2 diabetes mellitus (T2DM). Although cross-sectional associations have been reported, primarily for Pro12Ala, few longitudinal studies in nondiabetic populations have been conducted.
Objective: This study aimed to examine whether and to what extent variation in PPARG is associated with longitudinal changes in anthropometric and metabolic traits in Mexican Americans at risk for T2DM.