1 results match your criteria: "USAHelmy Institute for Medical SciencesCenter for Aging and Associated Diseases[Affiliation]"
Distinct pathways of cholesterol biosynthesis impact on insulin secretion.
J Endocrinol
January 2015
Department of Physiology and BiophysicsInstitute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-000 São Paulo, BrazilDepartment of AnesthesiologyVA San Diego Healthcare System and University of California-San Diego, VASDHS (9125), 3350 La Jolla Village Drive, San Diego, California 92161, USAHelmy Institute for Medical SciencesCenter for Aging and Associated Diseases, Zewail City of Sciences and Technology, Giza, Egypt.
Results from previous investigations have indicated that glucose-stimulated insulin secretion (GSIS) is affected by changes in cholesterol and its intermediates, but the precise link between secretion and cholesterol has not been thoroughly investigated. In this study, we show the contribution of both protein isoprenylation and cholesterol-dependent plasma membrane structural integrity to insulin secretion in INS-1E cells and mouse islets. Acute (2 h) inhibition of hydroxyl-methylglutaryl-CoA reductase by simvastatin (SIM) resulted in inhibition of GSIS without reduction in total cellular cholesterol content.
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