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Extracellular DNA in cord blood plasma and applications in cord blood banking for sample identification.
Transfusion
August 2009
National Cord Blood Program, 310 E 67 Street, New York, NY 10065, USA.
Article Synopsis
- The study explores whether human genomic DNA exists in the plasma of cord blood (CB) units, which could assist in accurate genetic identification.
- The researchers confirmed that extracellular DNA (EC-DNA) levels are significantly higher in CB plasma compared to adult plasma and noted that these levels increase over time with reduced cell viability.
- These findings suggest that using EC-DNA from CB plasma could reliably verify the identity of plasma aliquots in CB banking, enhancing traceability and safety in transplantation.