Placenta microbiology and histology and the risk for severe retinopathy of prematurity.

Purpose: To test the hypothesis that the presence of bacteria and/or histologic inflammation in the placenta of infants born preterm is associated with an increased risk for severe retinopathy of prematurity (ROP).

Methods: This was a prospective cohort study. Exploratory and multivariable data analyses were used, including logistic regression models with interaction terms.

Infection, oxygen, and immaturity: interacting risk factors for retinopathy of prematurity.

Background: Interactions among known risk factors for retinopathy of prematurity (ROP) remain to be clarified.

Objectives: The aim of this study was to identify risk factors associated with ROP and to explore the interrelationships between prominent risk factors for ROP.

Methods: From an institutional cohort of 1,646 very preterm newborns with gestational age <30 weeks or birth weight <1,501 g, we selected infants with a gestational age <30 weeks who met the criteria for ROP screening (n = 622) for a nested case-control analysis.

High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis.

Context: Low oxygen saturation appears to decrease the risk of severe retinopathy of prematurity (ROP) in preterm newborns when administered during the first few weeks after birth. High oxygen saturation seems to reduce the risk at later postmenstrual ages (PMAs). However, previous clinical studies are not conclusive individually.

Maternal obesity and neonatal Apgar scores.

Objective: To determine whether maternal obesity in early pregnancy is associated with low neonatal 5-min Apgar scores while adjusting for confounders.

Methods: Data were obtained from Maine State Birth Records Database. Analyses were restricted to information on 58,089 white women and their newborns.