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Radiofrequency ablation: effect of tumor- and organ-specific pharmacologic modulation of arterial and portal venous blood flow on coagulation diameter in an N1-S1 tumor model.

J Vasc Interv Radiol

June 2012

Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.

Article Synopsis
  • The study aimed to compare tumor and normal liver blood flow differences and assess the effectiveness of radiofrequency (RF) ablation combined with glucagon, adenosine, or saline in rats.
  • Results showed that glucagon and adenosine significantly reduced the blood flow in tumors compared to saline, with glucagon and adenosine achieving over 66% reduction.
  • Post-ablation, the treated tumors showed a 100%-165% increase in the ablated area, indicating that medication could effectively change blood flow and potentially improve tumor treatment strategies.
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