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Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer.
Lancet
August 2003
Breast Center and the Departments of Medicine, Pathology, and Molecular and Cellular Biology, Baylor College of Medicine, and the Methodist Hospital, Houston, TX 77030, USA.
Background: Systemic chemotherapy for operable breast cancer substantially decreases the risk of death. Patients often have de novo resistance or incomplete response to docetaxel, one of the most active agents in this disease. We postulated that gene expression profiles of the primary breast cancer can predict the response to docetaxel.
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