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Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan.
Nat Microbiol
June 2023
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Article Synopsis
- The study explores the gut virome of centenarians, revealing that they possess a more diverse range of viruses compared to younger and older adults.
- It identifies new viral genera linked to Clostridia and shows a shift towards increased lytic viral activity in centenarians.
- Additionally, the research suggests that enhanced phage-encoded functions in centenarians may aid in essential metabolic pathways, potentially improving gut health and immune resistance.