2 results match your criteria: "USA. Phamrah@tuftsmedicalcenter.org.[Affiliation]"
Herpes simplex virus-1 KOS-63 strain is virulent and causes titer-dependent corneal nerve damage and keratitis.
Sci Rep
February 2021
Department of Ophthalmology, Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA.
To investigate the acute clinical, immunological, and corneal nerve changes following corneal HSV-1 KOS-63 strain inoculation. Corneas of C57BL/6 mice were inoculated with either low dose (Ld) or high dose (Hd) HSV-1 KOS-63 or culture medium. Clinical evaluation was conducted up to 7 days post inoculation (dpi).
View Article and Find Full Text PDFEffect of herpes simplex keratitis scar location on bilateral corneal nerve alterations: an in vivo confocal microscopy study.
Br J Ophthalmol
March 2022
Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
Article Synopsis
- The study investigates how the location of herpes simplex virus (HSV)-induced scars affects nerve density in the cornea using a technique called in vivo confocal microscopy (IVCM).
- It involved 39 patients with unilateral corneal scars, with nerve density measured and compared against 24 age-matched controls, revealing significant decreases in nerve density and corneal sensation in affected eyes.
- The results indicate that both central and peripheral corneal nerve densities decrease due to HSV scars, and interestingly, the nerve density also diminishes in the asymptomatic, contralateral eyes, reflecting the pattern of scar distribution.