2 results match your criteria: "USA. Luke.Rothermel@UHHospitals.org.[Affiliation]"
ASO Author Reflections: The Association Between Sentinel Lymph Node Biopsy and Melanoma-Specific Survival in the Elderly.
Ann Surg Oncol
November 2024
University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.
J Exp Clin Cancer Res
September 2022
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Background: Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency in cancer. The enzyme protects cancer cells under metabolic stress, including nutrient limited conditions in the tumor microenvironment.
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