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USA. Icahn School of Medicine at Mount ... Publications | LitMetric

13 results match your criteria: "USA. Icahn School of Medicine at Mount Sinai[Affiliation]"

Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate.

bioRxiv

September 2024

Department of Cell, Developmental, and Regenerative Biology, Mount Sinai, New York, NY 10029, USA.

Article Synopsis
  • Cardiac Purkinje fibers are crucial for coordinating heart contractions and understanding their biology is limited due to challenges in creating these cells from human stem cells.
  • Researchers analyzed single-cell data from mouse hearts to identify key signaling pathways, such as Notch signaling, that are involved in the formation of Purkinje fiber cells.
  • Activating Notch signaling in human embryonic stem cell-derived cardiomyocytes not only transformed their shape and electrical properties to resemble Purkinje fibers but also altered their gene expression, resulting in lower contractile force and differing responses to anti-arrhythmogenic drugs.
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Digital therapeutics have evolved rapidly with technological advances in healthcare. Despite their increasing use, gaps remain in understanding their regulatory frameworks, integration, and efficacy for conditions like substance use disorder, insomnia, attention deficit hyperactivity disorder, and post-traumatic stress disorder. This study evaluates FDA-approved digital therapeutics and explores their potential to revolutionize psychiatric treatments amid ongoing technological and regulatory changes.

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Objective: The COVID-19 pandemic altered health outcomes in populations through a host of downstream social, economic, and psychological changes, especially among those with chronic non-communicable diseases (NCDs). Some studies reveal worsened glycemic control and weight gain, while others indicate improved glycemic control and weight loss. Thus, evidence demonstrates conflicting results in this context.

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Background: Diabetes mellitus (DM) is common among persons experiencing homelessness (PEH), often inadequately managed, and carries significant costs. mHealth strategies including short messaging service (SMS) texting have been feasible and acceptable, and improved control of chronic diseases including DM. SMS strategies for DM have not been tested among PEH despite the accessibility of mobile phones.

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Background: As the pandemic wanes, there is an opportunity to reevaluate resultant changes in graduate medical education (GME), particularly from the viewpoints of those affected most. We aimed to assess both trainee and faculty perceptions on the educational changes and innovations resulting from the pandemic to inform future educational planning.

Methods: We surveyed trainees and core education faculty at three New York City children's hospitals.

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Introduction Laparoscopic (LAP) colectomy is now the "gold" standard for diverticulitis; the role of hand-assisted LAP (HAL) and Open methods today is unclear. This study assessed the elective use of these methods for diverticulitis. Methods A retrospective review of demographic, comorbidity (Carlson Comorbidity Index [CCI]), resection type, and short-term outcomes was carried out.

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Background: Knowledge about the harms of tobacco use deters initiation and is associated with cessation. Most studies on this knowledge in the general population have been in high-income countries, but the tobacco use burden is increasing in low-income and middle-income countries. We sought to estimate levels of knowledge about tobacco-related diseases in 22 countries and determine the factors associated with differences in knowledge.

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In vivo comparison between cardiac allograft vasculopathy and native atherosclerosis using near-infrared spectroscopy and intravascular ultrasound.

Eur Heart J Cardiovasc Imaging

September 2015

NewYork-Presbyterian/Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, New York, NY, USA Department of Cardiology, Shaare Zedek Medical Center, 12 Shmuel (Hans) Beyth Street, Jerusalem 91031, Israel

Aims: The aim was to compare cardiac allograft vasculopathy to native atherosclerosis by near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS).

Methods And Results: Twenty-seven atherosclerotic (non-transplant) patients and 28 heart transplant recipients undergoing routine surveillance coronary angiography underwent NIRS-IVUS imaging of the left anterior descending coronary artery. In each proximal, middle, and distal coronary artery segment, the maxLCBI4mm [4-mm long segment with maximum lipid core burden index (LCBI)] and corresponding IVUS parameters were compared.

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Predictors of new-onset distal neuropathic pain in HIV-infected individuals in the era of combination antiretroviral therapy.

Pain

April 2015

Children's Hospital, Los Angeles, CA, USA HIV Neurobehavioral Research Program, University of California, San Diego, CA, USA Icahn School of Medicine at Mount Sinai, New York, NY University of Washington, Seattle, WA, USA Washington University, St Louis, MO, USA University of Texas Medical Branch, Galveston, TX San Diego State University, San Diego, CA Alliant International University, San Diego, CA.

Despite modern combination antiretroviral therapy, distal neuropathic pain (DNP) continues to affect many individuals with HIV infection. We evaluated risk factors for new-onset DNP in the CNS Antiretroviral Therapy Effects Research (CHARTER) study, an observational cohort. Standardized, semiannual clinical evaluations were administered at 6 US sites.

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A news media analysis of the economic and reputational penalties of the hospital readmissions reduction program.

Inquiry

June 2015

The New York Academy of Medicine, New York, NY, USA Icahn School of Medicine at Mount Sinai, New York, NY, USA University of Pennsylvania, Philadelphia, PA, USA

Section 3025 of the Affordable Care Act (ACA) of 2010 established the Hospital Readmissions Reduction Program (HRRP), an initiative designed to penalize hospitals with excess 30-day readmissions. This study investigates whether readmission penalties under HRRP impose significant reputational effects on hospitals. Data extracted from 2012 to 2013 news stories suggest that the higher the actual penalty, the higher the perceived cost of the penalty, the more likely it is that hospitals will state they have no control over the low-income patients they serve or that they will describe themselves as safety net providers.

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Objective: Laquinimod is an oral therapeutic agent under investigation for the treatment of Crohn's disease (CD), Huntington's disease, lupus nephritis and multiple sclerosis. This dose escalation study evaluated the safety and efficacy of laquinimod as induction therapy in patients with active moderate-severe CD.

Design: Multicentre, double-blind, sequential-cohort, randomised controlled trial with laquinimod doses of 0.

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Objective: We examine the ways that romantic relationship biographies are related to whether, how, and with whom individuals complete advance care planning (ACP), preparations for end-of-life medical care.

Method: Data are from an Internet survey of 2,144 adults aged 18 to 64, all of whom were either married to or cohabiting with an opposite-sex partner.

Results: Cohabitors were less likely than married people to complete ACP.

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