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Molecular and pathologic characterization of AML with double Inv(3)(q21q26.2).

Cancer Genet

January 2019

Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Pathology, UH Cleveland Medical Center, 10524 Euclid Ave, Cleveland, OH 44106, USA. Electronic address:

The inv(3)(q21q26.2) altering a single chromosome 3 homolog is an established myeloid malignancy-associated entity. Comparatively, double inv(3) cases involving both homologs are exceedingly rare with 13 reports across AML, CML and MDS.

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