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What do we know about sex differences in depression: A review of animal models and potential mechanisms.
Prog Neuropsychopharmacol Biol Psychiatry
March 2019
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100012, China; Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA. Electronic address:
Clinical studies have shown that women are more susceptible to depression than men. Sex differences in depression have been associated with social, cultural, as well as biological factors. In spite of extensive preclinical studies in animal models for depression that have been used for understanding the mechanisms of the disease as well as for new drug development, a substantive lack of attention on sex-specific phenotypes in depression might mask the effect of sex on the outcome.
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