12 results match your criteria: "USA. Electronic address: phamrah@tuftsmedicalcenter.org.[Affiliation]"
Corneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study.
Ocul Surf
April 2023
Center for Translational Ocular Immunology, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA; Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Cornea Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:
Purpose: To assess the effect of corneal scar location on corneal nerve regeneration in patients with herpes simplex virus (HSV) keratitis in their affected and contralateral eyes over a 1-year period by in vivo confocal microscopy (IVCM), and to correlate these findings to corneal sensation measured by Cochet-Bonnet Esthesiometer.
Methods: Prospective, longitudinal, case-control study. Bilateral corneal nerve density and corneal sensation were analyzed centrally and peripherally in 24 healthy controls and 23 patients with unilateral HSV-related corneal scars using IVCM.
Density and distribution of dendritiform cells in the peripheral cornea of healthy subjects using in vivo confocal microscopy.
Ocul Surf
October 2022
Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Boston, MA, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Boston, MA, USA; Ocular Surface Imaging Center, Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Boston, MA, USA. Electronic address:
Purpose: To establish in a large healthy cohort, dendritiform cell (DC) density and morphological parameters in the central and peripheral cornea using in vivo confocal microscopy (IVCM).
Methods: A prospective, cross-sectional, observational study was conducted in 85 healthy volunteers (n = 85 eyes). IVCM images of corneal center and four peripheral zones were analyzed for DC density and morphology to compare means and assess correlations (p < 0.
Concurrent ocular pain in patients with neurotrophic keratopathy.
Ocul Surf
October 2021
Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical School, Tufts Medical Center School of Medicine, Boston, USA; Program in Neuroscience, School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA. Electronic address:
Purpose: To illustrate that ocular pain may occur in patients with neurotrophic keratopathy (NK) that typically are thought to lack symptoms of discomfort, and that aa subset of these patients may also present with neuropathic corneal pain (NCP).
Method: Retrospective Case series of 7 stage 1 NK patients who presented with concurrent ocular pain, as confirmed by clinical examination, proparacaine challenge test, and in vivo corneal confocal microscopy (IVCM). Records were assessed for results of ocular surface disease index (OSDI), pain on visual analog scale (VAS), ocular pain assessment survey (OPAS), best-corrected visual acuity (BCVA), corneal fluorescein staining (CFS) score, and IVCM findings.
Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions.
Ocul Surf
October 2021
Center for Translational Ocular Immunology, USA; Cornea Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine Boston, MA, USA. Electronic address:
Purpose: Describe the utility of anterior segment optical coherence tomography angiography (AS-OCTA) to assess ocular surface lesions.
Methods: Retrospective, case-control study of 10 eyes of 9 patients with malignant lesions and 23 eyes of 22 patients with benign lesions. Lesions included 13 epithelial, 10 pigmented and 10 lymphoid lesions.
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain.
Ocul Surf
April 2021
Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical, USA. Electronic address:
Article Synopsis
- - This study investigates the effectiveness of low-dose naltrexone (LDN) in treating neuropathic corneal pain (NCP), which can cause symptoms like burning and light sensitivity due to nerve damage.
- - A group of 59 patients with NCP received LDN for at least four weeks, and the study found a significant reduction in pain scores (nearly 50%) and improvement in quality of life.
- - The treatment was generally well-tolerated, with minor side effects such as vivid dreams and headaches reported by some patients.
Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis.
Cell Rep
September 2020
Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA; Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA; Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA; Program in Immunology, School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA; Cornea Service, Tufts New England Eye Center, Boston, MA, USA. Electronic address:
Article Synopsis
- Depleting pDCs leads to severe disease outcomes, including nerve damage and increased viral spread, while restoring them helps limit disease severity.
- pDCs are crucial for producing IFN-α and maintaining proper immune responses, highlighting their essential function in protecting the cornea from viral infections.
Efficacy and tolerability of nortriptyline in the management of neuropathic corneal pain.
Ocul Surf
October 2020
Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical School, Tufts University School of Medicine, Boston, USA. Electronic address:
Purpose: Neuropathic corneal pain (NCP) is a recently acknowledged disease entity. However, there is no consensus in potential treatment strategies, particularly in patients with a centralized component of pain. This study aims to assess the efficacy and tolerability of the tricyclic antidepressant, nortriptyline, among NCP patients.
View Article and Find Full Text PDFNovel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography.
Am J Ophthalmol
February 2021
Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA; Tufts Medical Center, Tufts University School of Medicine, and Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA. Electronic address:
Purpose: Assessment of anterior segment-optical coherence tomography angiography (AS-OCTA) to determine severity of corneal neovascularization (CoNV).
Design: Retrospective, cross-sectional, single-center study.
Methods: Patients of various CoNV etiologies were selected and classified into mild, moderate, and severe.
Comparison of clinical characteristics of post-refractive surgery-related and post-herpetic neuropathic corneal pain.
Ocul Surf
October 2020
Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical School, Tufts University School of Medicine, Boston, MA, USA; Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:
Article Synopsis
- - The study aimed to compare clinical features and confocal microscopy findings between patients with neuropathic corneal pain due to refractive surgery (RS-NCP) and herpetic eye disease (H-NCP), alongside healthy controls.
- - Sixteen RS-NCP patients, seven H-NCP patients, and 37 healthy controls were analyzed for pain intensity and quality of life, revealing similar experiences of pain and life disruptions in both patient groups.
- - Both RS-NCP and H-NCP patients exhibited lower nerve density compared to their respective controls, though alterations in dendritic cell density appeared consistent across all groups, indicating similar underlying issues in neuropathic corneal pain regardless of the cause.
Visualization of microneuromas by using in vivo confocal microscopy: An objective biomarker for the diagnosis of neuropathic corneal pain?
Ocul Surf
October 2020
Center for Translational Ocular Immunology and, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA; Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:
Article Synopsis
- The study investigates the challenge of diagnosing neuropathic corneal pain (NCP) and aims to identify an objective sign using in vivo confocal microscopy (IVCM) to differentiate it from dry eye disease (DED).
- A comparative analysis of patients was conducted, including those diagnosed with NCP, DED, and healthy controls, focusing on nerve density, microneuromas, and dendritiform cell density based on IVCM scans.
- Results indicated that while both NCP and DED patients had decreased nerve density, microneuromas were exclusively found in NCP patients, highlighting their potential as a key diagnostic feature for NCP.
The utility of anterior segment optical coherence tomography angiography for the assessment of limbal stem cell deficiency.
Ocul Surf
January 2021
Center for Translational Ocular Immunology, Tufts Medical Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA; Cornea Service, New England Eye Center, Tufts Medical Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA. Electronic address:
Purpose: To determine the utility of anterior segment optical coherence tomography angiography (AS-OCTA) in assessing limbal stem cell deficiency (LSCD).
Methods: Twenty-six eyes of 24 LSCD patients, classified clinically into stage I, II and III, and 12 eyes of 12 healthy subjects were included. AS-OCTA images were analyzed by two masked observers, measuring the maximum corneal vascular extension (CoVE) from the limbus to the furthest vessel over the cornea, and corneal vascular thickness (CoVT) from the most superficial to the deepest corneal vessel.
In Vivo Confocal Microscopy Demonstrates Increased Immune Cell Densities in Corneal Graft Rejection Correlating With Signs and Symptoms.
Am J Ophthalmol
July 2019
Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Center for Translational Ocular Immunology, and Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA. Electronic address:
Purpose: Diagnosis of graft rejection is based on patient symptoms and on clinical signs detected by slit-lamp biomicroscopy. This study investigated whether laser in vivo confocal microscopy (IVCM) can aid in the diagnosis of corneal graft rejection by detecting cellular corneal changes that take place after transplantation.
Design: Prospective case-control study.