16 results match your criteria: "USA. Electronic address: nkapur@tuftsmedicalcenter.org.[Affiliation]"
Serial Shock Severity Assessment Within 72 Hours After Diagnosis: A Cardiogenic Shock Working Group Report.
J Am Coll Cardiol
August 2024
The Cardiovascular Center, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address:
Article Synopsis
- The CSWG-SCAI staging system helps assess the severity of cardiogenic shock (CS) in patients, but there’s limited data on how these stages change over time and affect outcomes.
- This study analyzed data from 3,268 patients with acute myocardial infarction-related CS and heart failure-related CS to see how their SCAI stages changed over 72 hours.
- Findings showed that most patients’ stages changed within the first 24 hours, particularly those in stage B who had a high risk of worsening, indicating that early detection and ongoing evaluation are crucial for improving patient outcomes.
Impact of Female Sex on Cardiogenic Shock Outcomes: A Cardiogenic Shock Working Group Report.
JACC Heart Fail
December 2023
The Cardiovascular Center, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address:
Article Synopsis
- The study focused on comparing survival rates at discharge between women and men who experienced cardiogenic shock (CS) related to acute myocardial infarction (AMI) and heart failure (HF).
- Out of 5,083 CS patients, 1,522 were women, who showed worse survival rates and higher rates of vascular complications compared to men, particularly in the HF-CS group.
- The findings suggest that women are less likely to receive certain advanced treatments and may face unique challenges leading to poor outcomes, emphasizing the need for further research to improve their care.
Delaying reperfusion plus left ventricular unloading reduces infarct size: Sub-analysis of DTU-STEMI pilot study.
Cardiovasc Revasc Med
March 2024
Henry Ford Hospital, Detroit, MI, United States of America.
Article Synopsis
- The STEMI-DTU pilot study investigated the safety and practicality of using a trans-valvular pump for left ventricular (LV) unloading before reperfusion in patients with acute STEMI.
- A total of 50 patients with anterior STEMI were enrolled, but only 32 completed the study after excluding those who didn't meet criteria; cardiac imaging was used to assess infarct size and microvascular obstruction.
- Results showed that LV unloading did significantly reduce infarct size relative to the area at risk, particularly when performed within 180 minutes of symptom onset, but did not show a significant difference in microvascular obstruction between the two patient groups.
Clinical Course of Patients in Cardiogenic Shock Stratified by Phenotype.
JACC Heart Fail
October 2023
The CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address:
Background: Cardiogenic shock (CS) patients remain at 30% to 60% in-hospital mortality despite therapeutic innovations. Heterogeneity of CS has complicated clinical trial design. Recently, 3 distinct CS phenotypes were identified in the CSWG (Cardiogenic Shock Working Group) registry version 1 (V1) and external cohorts: I, "noncongested;" II, "cardiorenal;" and III, "cardiometabolic" shock.
View Article and Find Full Text PDFClinical impact of pulmonary artery catheter in patients with cardiogenic shock: A systematic review and meta-analysis.
Cardiovasc Revasc Med
October 2023
The Cardiovascular Center, Tufts Medical Center and Tufts University School of Medicine, MA, USA. Electronic address:
Background: The clinical utility of the pulmonary artery catheter (PAC) for the management of cardiogenic shock (CS) remains controversial. We performed a systematic review and meta-analysis exploring the association between PAC use and mortality among patients with CS.
Methods: Published studies of patients with CS treated with or without PAC hemodynamic guidance were retrieved from MEDLINE and PubMed databases from January 1, 2000, to December 31, 2021.
Time Is "Not" on Your Side When Managing Cardiogenic Shock, a Loaded Ventricle, and VA-ECMO.
JACC Heart Fail
March 2023
Baylor University Medical Center, Dallas, Texas, USA.
Clinical Presentation and In-Hospital Trajectory of Heart Failure and Cardiogenic Shock.
JACC Heart Fail
February 2023
The CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA. Electronic address:
Article Synopsis
- Heart failure-related cardiogenic shock (HF-CS) is a critical but under-researched condition, prompting a study on a large patient cohort to assess shock severity and management practices using the SCAI staging system.
- The study analyzed 1,767 HF-CS patients from various clinical sites, revealing that nearly 20% presented with de novo HF-CS, often in more severe stages (C or D) and facing a higher risk of in-hospital death and cardiac arrest.
- The findings indicated that many patients received acute mechanical circulatory support (AMCS), highlighting the complexity and varied use of devices in managing HF-CS throughout hospitalization.
Criteria for Defining Stages of Cardiogenic Shock Severity.
J Am Coll Cardiol
July 2022
Cardiovascular Research Foundation, New York, New York, USA.
Background: Risk-stratifying patients with cardiogenic shock (CS) is a major unmet need. The recently proposed Society for Cardiovascular Angiography and Interventions (SCAI) staging system for CS severity lacks uniform criteria defining each stage.
Objectives: The purpose of this study was to test parameters that define SCAI stages and explore their utility as predictors of in-hospital mortality in CS.
REDUCE LAP-HF II interatrial shunt trial: neutral, but necessary.
Lancet
March 2022
CardioVascular Center, Tufts Medical Center, Boston, MA 02111, USA.
Left Ventricular Unloading Before Percutaneous Coronary Intervention is Associated With Improved Survival in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Systematic Review and Meta-Analysis.
Cardiovasc Revasc Med
June 2022
Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, USA; Cardiovascular Center, Tufts Medical Center and Tufts University School of Medicine, USA. Electronic address:
Background: Left ventricular unloading with Impella may improve survival outcomes in patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS). However, the optimal timing to initiate left ventricular unloading has yet to be established. Therefore, we conducted a systematic review and meta-analysis to compare survival in patients with AMI-CS who were supported with Impella prior to PCI (pre-PCI) to those in whom support was initiated following PCI (post-PCI).
View Article and Find Full Text PDFCardiac safety research consortium "shock II" think tank report: Advancing practical approaches to generating evidence for the treatment of cardiogenic shock.
Am Heart J
December 2020
Duke University Medical Center, Duke Clinical Research Institute, Durham Veterans Administration, Durham, NC. Electronic address:
Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure.
Cardiovasc Pathol
July 2018
Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA, 02111, USA. Electronic address:
Introduction: Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGFβ1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure.
Hypothesis: We tested the hypothesis that reduced ALK1 expression promotes maladaptive cardiac remodeling in heart failure.
Integrating Interventional Cardiology and Heart Failure Management for Cardiogenic Shock.
Interv Cardiol Clin
July 2017
Center for Advanced Heart Failure, University of Texas Health Medical School, 6400 Fannin Street, Houston, TX 77030, USA.
Cardiogenic shock remains one of the most common causes of in-hospital death. Recent data have identified an overall increase in patient complexity, with cardiogenic shock in the setting of acute myocardial infarction. The use of percutaneous acute mechanical circulatory support (AMCS) has steadily grown in the past decade.
View Article and Find Full Text PDFEndoglin selectively modulates transient receptor potential channel expression in left and right heart failure.
Cardiovasc Pathol
January 2017
Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA. Electronic address:
Article Synopsis
- Transient receptor potential (TRP) channels, including TRPC, TRPM, and TRPV subtypes, are involved in various physiological processes and have been linked to heart failure, particularly TRPC6's role in signaling with TGFβ1.
- The study aimed to investigate how heart failure affects TRP channel expression differently in the left (LV) and right (RV) ventricles, using tissue samples from patients and mouse models under pressure overload conditions.
- Results showed increased mRNA levels of several TRP channels in both failing LV and RV samples, with distinct patterns of expression, indicating potential specific roles for TRPC1 and TRPC6 in RV failure compared to LV.
Hemodynamic support with percutaneous devices in patients with heart failure.
Heart Fail Clin
April 2015
The Cardiovascular Center, Tufts Medical Center, 800 Washington Street, BOX 80, Boston, MA 02111, USA.
The use of surgically implanted durable mechanical circulatory support (MCS) in high-risk patients with heart failure is declining and short-term, nondurable MCS device use is growing. Percutaneously delivered MCS options for advanced heart failure include the intra-aortic balloon pump, Impella axial flow catheter, TandemHeart centrifugal pump, and venoarterial extracorporeal membrane oxygenation. Nondurable MCS devices have unique implantation characteristics and hemodynamic effects.
View Article and Find Full Text PDFPercutaneous Circulatory Assist Devices for Right Ventricular Failure.
Interv Cardiol Clin
July 2013
Department of Cardiology, The Cardiovascular Center, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
Heart failure is a major cause of global morbidity and mortality affecting nearly 24 million individuals worldwide. Although the importance of right ventricular (RV) function has become more apparent over the past few decades, few therapies specifically target RV failure. Over the past 3 decades, significant advances in percutaneously delivered circulatory support devices has led to the recent development of devices specifically designed for RV failure.
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