1 results match your criteria: "USA. Electronic address: jgalper@tuftsmedicalcenter.org.[Affiliation]"
Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3.
J Mol Cell Cardiol
October 2015
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA; Cardiovascular Center, Division of Cardiology, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address:
Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE(-/-)) mice infused with angiotensin II (AngII) develop AAA. Although AngII stimulates both JAK/STAT and Toll-like receptor 4 (TLR4) signaling pathways, their involvement in AngII mediated AAA formation is unclear.
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