3 results match your criteria: "USA. Electronic address: h.jacobs@maastrichtuniversity.nl.[Affiliation]"
Elevated norepinephrine metabolism is linked to cortical thickness in the context of Alzheimer's disease pathology.
Neurobiol Aging
June 2021
Faculty of Health, Medicine and Life Sciences; School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands; Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address:
Article Synopsis
- Advanced Alzheimer's disease (AD) shows increased levels of noradrenaline metabolites, indicating a potential link between these levels and AD pathology.
- The study examined 77 memory clinic patients, analyzing brain structure and fluid biomarkers to assess the relationship between noradrenaline turnover and brain morphology, focusing on the role of the locus coeruleus (LC).
- Results revealed that higher levels of the noradrenergic metabolite MHPG correlate with reduced cortical thickness and hippocampal volume, suggesting that these changes may occur early in the AD process, possibly aiding in early detection of the disease.
Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis.
Parkinsonism Relat Disord
May 2019
Department of Neurology, Maastricht University Medical Centre, P.O. Box 5800, 6202, AZ, Maastricht, the Netherlands. Electronic address:
Background: Cognitive impairment is a common non-motor symptom in Parkinson's disease. So far, the underlying pathophysiology remains unclear. Several alterations in functional network connectivity have been described in Parkinson's disease patients with cognitive impairment which are probably the result of the heterogenous pathophysiology underlying this cognitive decline, including dopaminergic and cholinergic deficits.
View Article and Find Full Text PDFCurvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study.
Neurobiol Aging
September 2018
Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands.
The locus coeruleus (LC) plays a crucial role in modulating several higher order cognitive functions via its widespread projections to the entire brain. We set out to investigate the hypothesis that LC functional connectivity (FC) may fluctuate nonlinearly with age and explored its relation to memory function. To that end, 49 cognitively healthy individuals (19-74 years) underwent ultra high-resolution 7T resting-state functional magnetic resonance imaging and cognitive testing.
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