2 results match your criteria: "USA. Electronic address: cheng@eyecenter.ucsd.edu.[Affiliation]"
Porous silicon oxide-PLGA composite microspheres for sustained ocular delivery of daunorubicin.
Acta Biomater
August 2014
Department of Ophthalmology, Jacobs Retina Center/Shiley Eye Center, University of California, San Diego, La Jolla, CA, USA. Electronic address:
A water-soluble anthracycline antibiotic drug (daunorubicin, DNR) was loaded into oxidized porous silicon (pSiO2) microparticles and then encapsulated with a layer of polymer (poly lactide-co-glycolide, PLGA) to investigate their synergistic effects in control of DNR release. Similarly fabricated PLGA-DNR microspheres without pSiO2, and pSiO2 microparticles without PLGA were used as control particles. The composite microparticles synthesized by a solid-in-oil-in-water emulsion method have mean diameters of 52.
View Article and Find Full Text PDFTunable sustained intravitreal drug delivery system for daunorubicin using oxidized porous silicon.
J Control Release
March 2014
Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California San Diego, La Jolla, USA. Electronic address:
Daunorubicin (DNR) is an effective inhibitor of an array of proteins involved in neovascularization, including VEGF and PDGF. These growth factors are directly related to retina scar formation in many devastating retinal diseases. Due to the short vitreous half-life and narrow therapeutic window, ocular application of DNR is limited.
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