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Separation of mediastinal shed blood during aortic valve surgery elicits a reduced inflammatory response.

J Cardiovasc Med (Hagerstown)

January 2016

aDivision of Cardiac Surgery, University of Brescia Medical School, Brescia, Italy bDivision of Cardiothoracic Surgery, Henry Ford Hospital, Detroit, Michigan, USA cDivision of Cardiology, University of Brescia Medical School, Brescia, Italy dDivision of Cardiothoracic Surgery, Columbia College of Physicians & Surgeons, New York, New York, USA eAga Khan University Medical School, Karachi, Pakistan.

Aims: The detrimental effects of inflammation following cardiopulmonary bypass (CPB) could negatively affect the postoperative outcome in a specific subset of high-risk patients. We therefore investigated the impact of a CPB circuit (Admiral, Eurosets, Italy) that allows separation of intracavitary and mediastinal blood on the release of biochemical markers and clinical outcome when compared with a conventional circuit.

Methods: Thirty patients undergoing aortic valve surgery were prospectively enrolled and assigned to Admiral group (Group 1, G1, n = 15) or conventional CPB group (Group 2, G2, n = 15).

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