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Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes.
Nucleic Acids Res
December 2013
Department of Pharmacology and Toxiocology, College of Pharmacy, University of Arizona, 1703 E. Mabel St, Tucson, AZ 85721, USA, Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA, BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA and The Arizona Cancer Center, Tucson, AZ 85724, USA.
Unlabelled: Vascular endothelial growth factor (VEGF) proximal promoter region contains a poly G/C-rich element that is essential for basal and inducible VEGF expression. The guanine-rich strand on this tract has been shown to form the DNA G-quadruplex structure, whose stabilization by small molecules can suppress VEGF expression. We report here the nuclear magnetic resonance structure of the major intramolecular G-quadruplex formed in this region in K(+) solution using the 22mer VEGF promoter sequence with G-to-T mutations of two loop residues.
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