1 results match your criteria: "USA and Chemical Industry Institute of Toxicology[Affiliation]"
Quantitative low-dose assessment of seafood toxin, domoic acid, in the rat brain: application of physiologically-based pharmacokinetic (PBPK) modeling.
Environ Toxicol Pharmacol
August 1998
Division of Toxicological Research (HFS-506), Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA and Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709, USA.
The purpose of this study was to construct a physiologically based pharmacokinetic model and demonstrate its ability to predict low-dose uptake of domoic acid, a seafood contaminant, in discrete areas of the rat brain. The model we used was derived from the generic PBPK model of our previous studies with 2,4-dichlorophenoxyacetic acid (Kim et al., 1994.
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