2 results match your criteria: "USA Vanderbilt Institute of Chemical Biology[Affiliation]"
Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection.
mBio
May 2016
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Unlabelled: Chikungunya virus (CHIKV) is a reemerging alphavirus that has caused epidemics of fever, arthralgia, and rash worldwide. There are currently no licensed vaccines or antiviral therapies available for the prevention or treatment of CHIKV disease. We conducted a high-throughput, chemical compound screen that identified digoxin, a cardiac glycoside that blocks the sodium-potassium ATPase, as a potent inhibitor of CHIKV infection.
View Article and Find Full Text PDFInhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.
J Alzheimers Dis
September 2015
Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, Nashville, TN, USA Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA Vanderbilt Institute of Chemical Biology, Nashville, TN, USA.
Curcumin is a promising compound that can be used as a theranostic agent to aid research in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also cross the blood-brain barrier. Presently, curcumin can be applied only to animal models, as the formulation needed for iv injection renders it unfit for human use.
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