27 results match your criteria: "USA Stanford University[Affiliation]"
SARS-CoV-2 Vaccination and Antibody Testing in Immunosuppressed Populations: You Can't Tell the Players Without a Scorecard [RETRACTED].
Transplantation
June 2021
University of Cincinnati, College of Medicine, Department of Surgery, Division of Transplantation, Cincinnati, OH, USA. Emory University, Department of Pathology, Division of Laboratory Medicine, Atlanta, GA, USA. New York University Langone Transplant Institute, NYU Langone Health, New York, New York, USA. Stanford University School of Medicine, Department of Medicine, and VA Palo Alto Health Care System, Palo Alto, CA, USA.
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.
Immunity
March 2017
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology and Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:
Type III interferons (IFN-λs) signal through a heterodimeric receptor complex composed of the IFN-λR1 subunit, specific for IFN-λs, and interleukin-10Rβ (IL-10Rβ), which is shared by multiple cytokines in the IL-10 superfamily. Low affinity of IL-10Rβ for cytokines has impeded efforts aimed at crystallizing cytokine-receptor complexes. We used yeast surface display to engineer a higher-affinity IFN-λ variant, H11, which enabled crystallization of the ternary complex.
View Article and Find Full Text PDFEvaluation of SMS reminder messages for altering treatment adherence and health seeking perceptions among malaria care-seekers in Nigeria.
Health Policy Plan
December 2016
General Medical Disciplines, School of Medicine, 1070 Arastradero Rd, Palo Alto, CA 94304 USA Stanford University.
In Nigeria, access to malaria diagnostics may be expanded if drug retailers were allowed to administer malaria rapid diagnostic tests (RDTs). A 2012 pilot intervention showed that short message service (SMS) reminder messages could boost treatment adherence to RDT results by 10-14% points. This study aimed to replicate the SMS intervention in a different population, and additionally test the effect of an expanded message about anticipated RDT access policy change on customers' acceptability for drug retailers' administration of RDTs.
View Article and Find Full Text PDFRadiocarbon constraints imply reduced carbon uptake by soils during the 21st century.
Science
September 2016
Department of Earth System Science, University of California, Irvine, CA, USA.
Soil is the largest terrestrial carbon reservoir and may influence the sign and magnitude of carbon cycle-climate feedbacks. Many Earth system models (ESMs) estimate a significant soil carbon sink by 2100, yet the underlying carbon dynamics determining this response have not been systematically tested against observations. We used C data from 157 globally distributed soil profiles sampled to 1-meter depth to show that ESMs underestimated the mean age of soil carbon by a factor of more than six (430 ± 50 years versus 3100 ± 1800 years).
View Article and Find Full Text PDFLaboratory Diagnosis of Congenital Toxoplasmosis.
J Clin Microbiol
October 2016
Palo Alto Medical Foundation Toxoplasma Serology Laboratory, National Reference Center for the Study and Diagnosis of Toxoplasmosis, Palo Alto, California, USA Stanford University, Division of Infectious Diseases, Stanford, California, USA
Recent studies have demonstrated that screening and treatment for toxoplasmosis during gestation result in a decrease of vertical transmission and clinical sequelae. Early treatment was associated with improved outcomes. Thus, laboratory methods should aim for early identification of infants with congenital toxoplasmosis (CT).
View Article and Find Full Text PDFPrevention and Treatment of Pain in Children: Toward a Paradigm Shift.
Otolaryngol Head Neck Surg
May 2016
Stanford Children's Health, Stanford, California, USA Stanford University School of Medicine, Stanford, California, USA.
Rosenfeld et al in their recent article "Office Insertion of Tympanostomy Tubes without Anesthesia in Young Children" describe using a "papoose board for restraint" while performing a procedure resulting in severe pain for a significant number of children: a myringotomy and tube insertion. In 2016, it is inappropriate to perform elective painful procedures in children without treatment to avoid or minimize pain. We strongly disagree with the authors' conclusion "that office insertion of tubes in young children is a feasible alternative to general anesthesia for caregivers and clinicians who are comfortable with this choice.
View Article and Find Full Text PDFHigh-sensitivity cardiac troponin I and incident coronary heart disease among asymptomatic older adults.
Heart
August 2016
Kaiser Permanente Northern California Division of Research, Oakland, California, USA San Francisco Departments of Epidemiology, University of California, Biostatistics and Medicine, San Francisco, California, USA Stanford University School of Medicine, Palo Alto, California, USA.
Objective: High-sensitivity cardiac troponin I (hs-cTnI) is a novel biomarker of myocardial injury and ischaemia. Our objective was to ascertain correlates of hs-cTnI and its incremental prognostic utility for incident coronary heart disease (CHD) among older asymptomatic subjects.
Methods: We performed a cohort study among 1135 asymptomatic control participants in the ADVANCE (Atherosclerotic Disease, VAscular FunctioN and GenetiC Epidemiology) study at Kaiser Permanente Northern California and Stanford University, with follow-up through 31 December 2014.
Design and Implementation of a Perioperative Surgical Home at a Veterans Affairs Hospital.
Semin Cardiothorac Vasc Anesth
June 2016
VA Palo Alto Health Care System, Palo Alto, CA, USA Stanford University School of Medicine, Palo Alto, CA, USA
The innovative Perioperative Surgical Home model aims to optimize the outcomes of surgical patients by leveraging the expertise and leadership of physician anesthesiologists, but there is a paucity of practical examples to follow. Veterans Affairs health care, the largest integrated system in the United States, may be the ideal environment in which to explore this model. We present our experience implementing Perioperative Surgical Home at one tertiary care university-affiliated Veterans Affairs hospital.
View Article and Find Full Text PDFSignificance of a Positive Toxoplasma Immunoglobulin M Test Result in the United States.
J Clin Microbiol
November 2015
Palo Alto Medical Foundation Toxoplasma Serology Laboratory, National Reference Center for the Study and Diagnosis of Toxoplasmosis, Palo Alto, California, USA Stanford University, Division of Infectious Diseases, Stanford, California, USA
A positive Toxoplasma immunoglobulin M (IgM) result is often interpreted as a marker of an acute infection. However, IgM can persist for several years, and Toxoplasma commercial IgM diagnostic test kits can yield a number of false-positive results. For these reasons, a chronic Toxoplasma infection can be erroneously classified as an acute infection, resulting in serious adverse consequences, especially in pregnant women, leading to emotional distress and unnecessary interventions, including termination of pregnancy.
View Article and Find Full Text PDFA Systematic Review of Family Meeting Tools in Palliative and Intensive Care Settings.
Am J Hosp Palliat Care
September 2016
RAND Corporation, Santa Monica, CA, USA Fielding School of Public Health, University of California at Los Angeles, Los Angeles, CA, USA.
Purpose: Family meetings can be challenging, requiring a range of skills and participation. We sought to identify tools available to aid the conduct of family meetings in palliative, hospice, and intensive care unit settings.
Methods: We systematically reviewed PubMed for articles describing family meeting tools and abstracted information on tool type, usage, and content.
Bacteraemic urinary tract infection: management and outcomes in young infants.
Arch Dis Child
February 2016
Department of Pediatrics, Kaiser Permanente Northern California, San Francisco, California, USA.
Objectives: To determine predictors of parenteral antibiotic duration and the association between parenteral treatment duration and relapses in infants <3 months with bacteraemic urinary tract infection (UTI).
Design: Multicentre retrospective cohort study.
Setting: Eleven healthcare institutions across the USA.
Developmental origin of age-related coronary artery disease.
Cardiovasc Res
July 2015
Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA Sanford-Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92037, USA
Aim: Age and injury cause structural and functional changes in coronary artery smooth muscle cells (caSMCs) that influence the pathogenesis of coronary artery disease. Although paracrine signalling is widely believed to drive phenotypic changes in caSMCs, here we show that developmental origin within the fetal epicardium can have a profound effect as well.
Methods And Results: Fluorescent dye and transgene pulse-labelling techniques in mice revealed that the majority of caSMCs are derived from Wt1(+), Gata5-Cre(+) cells that migrate before E12.
Surgical team member assessment of the safety of surgery practice in 38 South Carolina hospitals.
Med Care Res Rev
June 2015
Harvard T. H. Chan School of Public Health, Boston, MA, USA Ariadne Labs, Boston, MA, USA.
We assessed surgical team member perceptions of multiple dimensions of safe surgical practice in 38 South Carolina hospitals participating in a statewide initiative to implement surgical safety checklists. Primary data were collected using a novel 35-item survey. We calculated the percentage of 1,852 respondents with strongly positive, positive, and neutral/negative responses about the safety of surgical practice, compared results by hospital and professional discipline, and examined how readiness, teamwork, and adherence related to staff perception of care quality.
View Article and Find Full Text PDFEcological momentary assessment of tinnitus using smartphone technology: a pilot study.
Otolaryngol Head Neck Surg
May 2015
Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis, School of Medicine, St Louis, Missouri, USA
Objective: To explore the feasibility of ecological momentary assessments (EMAs) as a tool to more accurately assess the level of bother from tinnitus.
Study Design: Longitudinal observational study.
Setting: Washington University Department of Otolaryngology-Head and Neck Surgery faculty practice plan.
Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations.
Pain
September 2014
University of Rochester, Rochester, NY, USA University of Washington, Seattle, WA, USA University of Kiel, Kiel, Germany Metrum Research Group, Tariffville, CT, USA Queen's University, Kingston, Ontario, Canada Analgesic Solutions, Natick, MA, USA Tufts University, Boston, MA, USA Cytel, Boston, MA, USA Johns Hopkins University, Baltimore, MD, USA CRP Santé, Strassen, Luxembourg CP Taylor Consulting, Ann Arbor, MI, USA American Chronic Pain Association, Rocklin, CA, USA Desjardins Associates and Rutgers University, Newark, NJ, USA Allergan, Irvine, CA, USA East Carolina University, Greenville, NC, USA University of Pennsylvania, Philadelphia, PA, USA Merck, Blue Bell, PA, USA Eli Lilly, Indianapolis, IN, USA Virtuous Pharma, Inc., Raleigh-Durham, NC, USA University of Helsinki, Helsinki, Finland VA Connecticut Healthcare System, West Haven, CT, USA Richard L Leff MD LLC, Chadds Ford, PA, USA Stanford University, Stanford, CA, USA California Pacific Medical Center, San Francisco, CA, USA Voyager Therapeutics, Cambridge, MA, USA Johnson and Johnson, Raritan, NJ, USA Imperial College, London, UK Faculdade de Medicina de Lisboa, Lisbon, Portugal University of Southern Denmark, Odense, Denmark Alpharma, Piscataway, NJ, USA Grünenthal GMbH, Aachen, Germany GlaxoSmithKline, Research Triangle Park, NC, USA Jazz Pharmaceuticals, Palo Alto, CA, USA Heidelberg University, Mannheim, Germany University of California San Diego, San Diego, CA, USA Endo Pharmaceuticals, Chadds Ford, PA, USA.
Proof-of-concept (POC) clinical trials play an important role in developing novel treatments and determining whether existing treatments may be efficacious in broader populations of patients. The goal of most POC trials is to determine whether a treatment is likely to be efficacious for a given indication and thus whether it is worth investing the financial resources and participant exposure necessary for a confirmatory trial of that intervention. A challenge in designing POC trials is obtaining sufficient information to make this important go/no-go decision in a cost-effective manner.
View Article and Find Full Text PDFResponse to letter to the editor.
Pain
May 2014
Departments of Anesthesiology and Neurology and Center for Human Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA University of Rochester, Rochester, NY, USA Stanford University, Palo Alto, CA, USA Johns Hopkins University, Baltimore, MD, USA Oregon Health and Science University, Portland, OR, USA Northwestern University, Chicago, IL, USA University of Wisconsin, Madison, WI, USA University of Kiel, Kiel, Germany Schmerzfachpraxis, Krefeld, Germany University of Washington, Seattle, WA, USA Universität Heidelberg, Mannheim, Germany Pain Matters, Liverpool, UK.
Female Sexual Victimization Among College Students: Assault Severity, Health Risk Behaviors, and Sexual Functioning.
J Interpers Violence
September 2014
Department of Psychology, California State University San Bernardino, CA, USA.
The purpose of the present study was to examine the relationship between college women's sexual victimization experiences, health risk behaviors, and sexual functioning. A sample of 309 college women at a mid-sized Midwestern university completed measures assessing sexual victimization, sexual risk taking, substance use behaviors, sexual desire, sexual functioning, prior sexual experiences, and social desirability. Severity of sexual victimization was measured using a multi-item, behaviorally specific, gender-neutral measure, which was divided into four categories based on severity (none, sexual contact, sexual coercion, rape).
View Article and Find Full Text PDFResponse to: Letter from Paul Eugene Summers, Federico Giove, and Carlo Adolfo Porro.
Pain
November 2013
Stanford University School of Medicine, Department of Anesthesiology, Division of Pain Medicine, Palo Alto, CA 94304, USA Stanford University School of Medicine, Department of Radiology, Palo Alto, CA 94304, USA.
Temporal stability of conditioned pain modulation in healthy women over four menstrual cycles at the follicular and luteal phases.
Pain
December 2013
United Biosource Corporation, Outcomes Research, USA Stanford University Medical Center, Stanford, CA, USA Department of Nursing, Faculty of Social Welfare and Health Studies, University of Haifa, Haifa, Israel University of Washington, Seattle, WA, USA.
Conditioned pain modulation (CPM) is a phenomenon that may be tested with a dynamic quantitative sensory test that assesses the inhibitory aspect of this pain modulatory network. Although CPM has been adopted as a clinical assessment tool in recent years, the stability of the measure has not been determined over long time intervals. The question of stability over time is crucial to our understanding of pain processing, and critical for the use of this tool as a clinical test.
View Article and Find Full Text PDFInterventional management of neuropathic pain: NeuPSIG recommendations.
Pain
November 2013
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA Department of Neurology, Center for Human Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA University of Rochester, Rochester, NY, USA Stanford University, Palo Alto, CA, USA Johns Hopkins University, Baltimore, MD, USA Oregon Health and Science University, Portland, OR, USA Northwestern University, Chicago, IL, USA University of Wisconsin, Madison, WI, USA University of Kiel, Kiel, Germany Schmerzfachpraxis, Krefeld, Germany University of Washington, Seattle, WA, USA Universität Heidelberg, Mannheim, Germany Pain Matters, Liverpool, UK.
Neuropathic pain (NP) is often refractory to pharmacologic and noninterventional treatment. On behalf of the International Association for the Study of Pain Neuropathic Pain Special Interest Group, the authors evaluated systematic reviews, clinical trials, and existing guidelines for the interventional management of NP. Evidence is summarized and presented for neural blockade, spinal cord stimulation (SCS), intrathecal medication, and neurosurgical interventions in patients with the following peripheral and central NP conditions: herpes zoster and postherpetic neuralgia (PHN); painful diabetic and other peripheral neuropathies; spinal cord injury NP; central poststroke pain; radiculopathy and failed back surgery syndrome (FBSS); complex regional pain syndrome (CRPS); and trigeminal neuralgia and neuropathy.
View Article and Find Full Text PDFUrologic chronic pelvic pain.
Pain
April 2012
900 Welch Road, Suite 202, Palo Alto, CA 94304, USA Stanford University Medical School, 300 Pasteur Drive, A260, Stanford, CA 94305-5118, USA.
A randomized, controlled trial of acceptance and commitment therapy and cognitive-behavioral therapy for chronic pain.
Pain
September 2011
VA San Diego Healthcare System, 3350 La Jolla Village Drive, Dept. 111N-1, San Diego, CA 92161, USA Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., Dept. 9111N-1, La Jolla, CA 92093-9111, USA Stanford University Medical Center, Department of Anesthesia, Division of Pain Management, 430 Broadway St., Pavilion C, MC 6343, Redwood City, CA 94063-3132, USA Alliant International University, 10455 Pomerado Rd., San Diego, CA, 92131, USA SDSU/UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct., Suite 103, San Diego, CA 92120-4913 USA Washington University, Department of Psychology, Campus Box 1125, One Brookings Drive, St. Louis, MO 63130-4899, USA.
Individuals reporting chronic, nonmalignant pain for at least 6 months (N=114) were randomly assigned to 8 weekly group sessions of acceptance and commitment therapy (ACT) or cognitive-behavioral therapy (CBT) after a 4-6 week pretreatment period and were assessed after treatment and at 6-month follow-up. The protocols were designed for use in a primary care rather than specialty pain clinic setting. All participants remained stable on other pain and mood treatments over the course of the intervention.
View Article and Find Full Text PDFDevelopment of a severity score for CRPS.
Pain
December 2010
Rehabilitation Institute of Chicago, Chicago, IL, USA Vanderbilt University School of Medicine, Nashville, TN, USA VU University Medical Center, Amsterdam, The Netherlands Trauma Related Neuronal Dysfunction Consortium (TREND), The Netherlands University Medical Center Mainz, Mainz, Germany Leiden University Medical Center, Leiden, The Netherlands University of Erlangen-Nuremberg, Erlangen, Germany Rush University Medical Center, Chicago, IL, USA Stanford University Medical Center, Stanford, CA, USA Reuth Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The clinical diagnosis of Complex Regional Pain Syndrome (CRPS) is a dichotomous (yes/no) categorization necessary for clinical decision-making. However, such dichotomous diagnostic categories do not convey an individual's subtle and temporal gradations in severity of the condition, and have poor statistical power when used as an outcome measure in research. This study evaluated the validity and potential utility of a continuous type score to index severity of CRPS.
View Article and Find Full Text PDFValidation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome.
Pain
August 2010
Rehabilitation Institute of Chicago, Chicago, IL, USA Vanderbilt University School of Medicine, Nashville, TN, USA VU University Medical Center, Amsterdam, The Netherlands Trauma Related Neuronal Dysfunction Consortium (TREND), Leiden University Medical Center, Leiden, The Netherlands University Medical Center Mainz, Mainz, Germany Leiden University Medical Center, Leiden, The Netherlands University of Erlangen-Nuremberg, Erlangen, Germany Rush University Medical Center, Chicago, IL, USA Stanford University Medical Center, Stanford, CA, USA Reuth Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients.
View Article and Find Full Text PDFContributions of change in clinical status parameters to Patient Global Impression of Change (PGIC) scores among persons with fibromyalgia treated with milnacipran.
Pain
May 2010
Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA Stanford University, Palo Alto, CA, USA Cypress Bioscience, Inc., San Diego, CA, USA Forest Research Institute, Jersey City, NJ, USA.
Clinical trials on the treatment of pain syndromes have adopted Patient Global Impression of Change (PGIC) as a primary outcome. However, little is known about how change in clinical status influences these ratings. The present study examined relationships between changes in pain, depressed mood, physical functioning, vitality, sleep disturbance, cognitive complaints, and PGIC ratings among 1260 participants with fibromyalgia (FM) who completed one of two trials examining the safety and efficacy of milnacipran.
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