1 results match your criteria: "USA Neurology and GI Center of Excellence for Drug Discovery[Affiliation]"
Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation.
Pain
August 2008
Center for the Neurobiology of Stress, Brain Research Institute, UCLA, Los Angeles, CA, USA Departments of Physiology, Psychiatry and Biobehavioral Sciences, Brain Research Institute, UCLA, Los Angeles, CA, USA VA GLA Healthcare System, Los Angeles, CA, USA Department of Biomedical Engineering, USC, Los Angeles, CA, USA Departments of Psychiatry and the Behavioral Sciences, Cell and Neurobiology, Neurology, USC, Los Angeles, CA, USA Neurology and GI Center of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
Article Synopsis
- Preclinical drug development for visceral pain primarily uses restrained rodents to study pain responses, but the relevance to human pain experiences remains uncertain.
- The study involved male rats undergoing colorectal distension (CRD) while measuring abdominal EMG and cerebral blood flow (rCBF) via advanced techniques.
- Results showed that CRD induced notable increases in both EMG activity and behavioral pain scores, with rCBF changes observed in various brain regions associated with sensory and emotional pain processing.
- This suggests that while CRD in rats can be a valid model for studying human visceral pain, there are more complex brain responses that traditional pain measures may not capture.