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Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use.

Brain

November 2015

1 Department of Psychiatry, University of California San Diego, La Jolla, CA, USA 4 Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA 5 Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.

Bayesian ideal observer models quantify individuals' context- and experience-dependent beliefs and expectations about their environment, which provides a powerful approach (i) to link basic behavioural mechanisms to neural processing; and (ii) to generate clinical predictors for patient populations. Here, we focus on (ii) and determine whether individual differences in the neural representation of the need to stop in an inhibitory task can predict the development of problem use (i.e.

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