An Enhanced Approach Using AGS Network for Skin Cancer Classification.

Skin cancer accounts for over 40% of all cancer diagnoses worldwide. However, accurately diagnosing skin cancer remains challenging for dermatologists, as multiple types of skin cancer often appear visually similar. The diagnostic accuracy of dermatologists ranges between 62% and 80%.

Racial and Geographic Disparities in Colorectal Cancer Incidence and Associated County-Level Risk Factors in Mississippi, 2003-2020: An Ecological Study.

Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States (U.S.).

Waste and Greenhouse Gas Emissions Produced from Ophthalmic Surgeries: A Scoping Review.

(1) Background: Healthcare is a major contributor to global greenhouse gas (GHG) emissions, especially within the surgical suite. Ophthalmologists play a role, since they frequently perform high-volume procedures, such as cataract surgery. This review aims to summarize the current literature on surgical waste and GHG emissions in ophthalmology and proposes a framework to standardize future studies.

Diverse and highly differentiated lava suite in Jezero crater, Mars: Constraints on intracrustal magmatism revealed by Mars 2020 PIXL.

The Jezero crater floor features a suite of related, iron-rich lavas that were examined and sampled by the Mars 2020 rover Perseverance, and whose textures, minerals, and compositions were characterized by the Planetary Instrument for X-ray Lithochemistry (PIXL). This suite, known as the Máaz formation (fm), includes dark-toned basaltic/trachy-basaltic rocks with intergrown pyroxene, plagioclase feldspar, and altered olivine and overlying trachy-andesitic lava with reversely zoned plagioclase phenocrysts in a K-rich groundmass. Feldspar thermal disequilibrium textures indicate that they were carried from their crustal staging area.

Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice.

Traumatic brain injury (TBI) is one of the major causes of severe neurological disorders and long-term dysfunction in the nervous system. Besides inducing neurodegeneration, TBI alters stem cell activity and neurogenesis within primary neurogenic niches. However, the fate of dividing cells in other brain regions remains unclear despite offering potential targets for therapeutic intervention.

Comparison of One-Drill Protocol to Sequential Drilling In Vitro and In Vivo.

This study compares the heat generated during bone drilling using different protocols and implant systems, first in vitro and then in vivo with an animal model. In the experimental phase, thermal data were collected using an infrared camera while preparing implant beds in bone similes. The heat generated by a one-drill protocol with a new-generation drill bit and the Straumann BLT sequential drilling protocol was evaluated.

Direct observation of small molecule activator binding to single PR65 protein.

The reactivation of heterotrimeric protein phosphatase 2A (PP2A) through small molecule activators is of interest to therapeutic intervention due to its dysregulation, which is linked to chronic conditions. This study focuses on the PP2A scaffold subunit PR65 and a small molecule activator, ATUX-8385, designed to bind directly to this subunit. Using a label-free single-molecule approach with nanoaperture optical tweezers (NOT), we quantify its binding, obtaining a dissociation constant of 13.

Metabolic tagging reveals surface-associated lipoproteins in mycobacteria.

Mycobacteria such as the causative agent of tuberculosis, , encode over 100 bioinformatically predicted lipoproteins. Despite the importance of these post-translationally modified proteins for mycobacterial survival, many remain experimentally unconfirmed. Here we characterized metabolic incorporation of diverse fatty acid analogues as a facile method of adding chemical groups that enable downstream applications such as detection, crosslinking and enrichment, of not only lipid-modified proteins, but also their protein interactors.

Resonantly Enhanced Hybrid Wannier-Mott-Frenkel Excitons in Organic-Inorganic Van Der Waals Heterostructures.

Hybrid excitons formed via resonant hybridization in 2D material heterostructures feature both large optical and electrical dipoles, providing a promising platform for many-body exciton physics and correlated electronic states. However, hybrid excitons at organic-inorganic interface combining the advantages of both Wannier-Mott and Frenkel excitons remain elusive. Here, hybrid excitons are reported in the copper phthalocyanine/molybdenum diselenide (CuPc/MoSe) heterostructure (HS) featuring strong molecular orientation dependence by low-temperature photoluminescence and absorption spectroscopy.

Enriched phenotypes in rare variant carriers suggest pathogenic mechanisms in rare disease patients.

Background: The mechanistic pathways that give rise to the extreme symptoms exhibited by rare disease patients are complex, heterogeneous, and difficult to discern. Understanding these mechanisms is critical for developing treatments that address the underlying causes of diseases rather than merely the presenting symptoms. Moreover, the same dysfunctional series of interrelated symptoms implicated in rare recessive diseases may also lead to milder and potentially preventable symptoms in carriers in the general population.

Toward a functional future for the cognitive neuroscience of human aging.

The cognitive neuroscience of human aging seeks to identify neural mechanisms behind the commonalities and individual differences in age-related behavioral changes. This goal has been pursued predominantly through structural or "task-free" resting-state functional neuroimaging. The former has elucidated the material foundations of behavioral decline, and the latter has provided key insight into how functional brain networks change with age.

Measuring trends in extinction risk: a review of two decades of development and application of the Red List Index.

The Red List Index (RLI) is an indicator of the average extinction risk of groups of species and reflects trends in this through time. It is calculated from the number of species in each category on the IUCN Red List of Threatened Species, with trends influenced by the number moving between categories when reassessed owing to genuine improvement or deterioration in status. The global RLI is aggregated across multiple taxonomic groups and can be disaggregated to show trends for subsets of species (e.

HPV Vaccines Among University Students: Understanding Barriers and Facilitators of Vaccine Uptake.

Human papillomavirus (HPV) is the most common sexually transmitted infection and plays a significant role in cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers as well as non-cancerous genital warts and genital dysplasia. In the United States, there are approximately 46,000 new HPV-related cancers a year. There is an effective vaccine to prevent over 90% of these cancers and other HPV-related diseases; however, those that are aged 18-26 have the lowest vaccine rates among eligible age groups.

Implant Surface Decontamination Methods That Can Impact Implant Wettability.

This review addresses the effects of various decontamination methods on the wettability of titanium and zirconia dental implants. Despite extensive research on surface wettability, there is still a significant gap in understanding how different decontamination techniques impact the inherent wettability of these surfaces. Although the literature presents inconsistent findings on the efficacy of decontamination methods such as lasers, air-polishing, UV light, and chemical treatments, the reviewed studies suggest that decontamination alters in vitro hydrophilicity.

Alzheimer's Disease: In Vitro and In Vivo Evidence of Activation of the Plasma Bradykinin-Forming Cascade and Implications for Therapy.

The plaques associated with Alzheimer's disease are formed as a result of the aggregation of Aβ peptides, which vary in length from 38 to 43 amino acids. The 1-40 peptide is the most abundant, while the 1-42 peptide appears to be the most destructive to neurons and/or glial cells in a variety of assays. We have demonstrated that aggregated Aβ, a state prior to plaque formation, will activate the plasma bradykinin-forming pathway when tested in vitro.

Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection.

Background/objectives: Although COVID-19 has been linked to worse outcomes in patients with neurological disorders, its impact on those with essential tremor (ET) remains unclear. To investigate clinical outcomes of ET patients with and without COVID-19 three and a half years post-pandemic.

Methods: 1074 ET patients were evaluated in this retrospective study in the Montefiore Health System from January 2016 to July 2023.

Additional analyses of stem catarrhine and hominoid dental morphology support Kapi ramnagarensis as a stem hylobatid.

Fossil gibbons are exceedingly rare, with much of the hylobatid fossil record and, consequently, hylobatid evolutionary history remaining unknown. Kapi ramnagarensis was described as a stem hylobatid on the basis of an isolated lower right M from ∼13.0-12.

Fluence rate-dependent kinetics of light-triggered liposomal doxorubicin assessed by quantitative fluorescence-based endoscopic probe.

Liposomal doxorubicin (Dox), a treatment option for recurrent ovarian cancer, often suffers from suboptimal biodistribution and efficacy, which might be addressed with precision drug delivery systems. Here, we introduce a catheter-based endoscopic probe designed for multispectral, quantitative monitoring of light-triggered drug release. This tool utilizes red-light photosensitive porphyrin-phospholipid (PoP), which is encapsulated in liposome bilayers to enhance targeted drug delivery.

Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis.

Background: Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of somatic mutations in myeloid and lymphoid malignancy genes in the blood cells of individuals without a hematologic malignancy. Inflammation is hypothesized to be a key mediator in the progression of CHIP to hematologic malignancy and patients with CHIP have a high prevalence of inflammatory diseases. This study aimed to identify the prevalence and characteristics of CHIP in patients with inflammatory bowel disease (IBD).

Curvature Dependence of Gravitational-Wave Tests of General Relativity.

High-energy extensions to general relativity modify the Einstein-Hilbert action with higher-order curvature corrections and theory-specific coupling constants. The order of these corrections imprints a universal curvature dependence on observations while the coupling constant controls the deviation strength. In this Letter, we leverage the theory-independent expectation that modifications to the action of a given order in spacetime curvature (Riemann tensor and contractions) lead to observational deviations that scale with the system length scale to a corresponding power.

Parametrization of Generalized Parton Distributions from t-Channel String Exchange in AdS Spaces.

We introduce a string-based parametrization for nucleon quark and gluon generalized parton distributions (GPDs) that is valid for all skewness. Our approach leverages conformal moments, representing them as the sum of spin-j nucleon A-form factor and skewness-dependent spin-j nucleon D-form factor, derived from t-channel string exchange in AdS spaces consistent with Lorentz invariance and unitarity. This model-independent framework, satisfying the polynomiality condition due to Lorentz invariance, uses Mellin moments from empirical data to estimate these form factors.

Efficacy of fisheries management strategies in mitigating ecological, social, and economic risks of climate warming in China.

Climate change has significantly altered fish population dynamics and marine ecosystems worldwide, resulting in multiple ecological, economic and social risks for sustainable fisheries. As a hotspot of global warming, China is anticipated to face with extensive climate-driven changes in marine fisheries and ecosystems, but a clear and adaptative management strategy has not been established. In this study, we assessed the climate adaptiveness of current fisheries management and alternative strategies with diverse management priorities.

Klebsiella pneumoniae Glycoconjugate Vaccine Leads Based on Semi-Synthetic O1 and O2ac Antigens.

Klebsiella pneumoniae (KP) is a common opportunistic pathogen that emerged as a new critical threat to human health, due to its hypervirulence and widespread resistance against many antibiotics, including carbapenems. Alternative intervention strategies such as vaccines are not available. Cell-surface lipopolysaccharides (LPS) and capsular polysaccharides (CPS) are attractive targets for vaccine development.