3 results match your criteria: "USA - Le Bonheur Children's Hospital[Affiliation]"
Standardized therapies after ECMO program (STEP); a novel approach to pediatric post-ECMO care.
J Extra Corpor Technol
September 2024
Department of Pediatrics, Division of Critical Care, University of Tennessee Health Science Center, Memphis, TN 38103, USA - Le Bonheur Children's Hospital, Memphis, TN 38103, USA.
Article Synopsis
- - The study evaluated the STEP program, aimed at improving post-discharge care for pediatric ECMO survivors in a hospital setting, focusing on guideline compliance.
- - After implementing STEP, there was a significant increase in the compliance rates for neurodevelopmental testing and follow-up evaluations in various therapeutic areas (e.g., neurology, audiology) among patients.
- - The results showed that STEP effectively enhanced adherence to follow-up guidelines, resulting in more timely and thorough neurodevelopmental assessments for ECMO survivors.
Ethanol lock therapy: a pilot infusion study in infants.
Ann Pharmacother
April 2015
Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA Le Bonheur Children's Hospital, Memphis, TN, USA Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA.
Background: Ethanol lock therapy (ELT) has emerged as an effective method for the prevention and treatment of central line-associated bloodstream infections (CLABSIs), but the safety of ELT in infants has not been established.
Objective: The objective of this study was to determine blood alcohol concentration (BAC) and evidence of hepatic injury in infants after infusing a small one-time dose of ethanol, equivalent to the volume that would be flushed through the central venous catheter (CVC) after ELT is completed.
Methods: This was a prospective pilot study in infants weighing ≤6 kg with and without liver dysfunction who had a CVC.
Limited type I interferons and plasmacytoid dendritic cells during neonatal respiratory syncytial virus infection permit immunopathogenesis upon reinfection.
J Virol
August 2014
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Unlabelled: Respiratory syncytial virus (RSV) infection is the number one cause of bronchiolitis in infants, yet no vaccines are available because of a lack of knowledge of the infant immune system. Using a neonatal mouse model, we previously revealed that mice initially infected with RSV as neonates develop Th2-biased immunopathophysiologies during reinfection, and we demonstrated a role for enhanced interleukin-4 receptor α (IL-4Rα) expression on T helper cells in these responses. Here we show that RSV infection in neonates induced limited type I interferon (IFN) and plasmacytoid dendritic cell (pDC) responses.
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