Performance of a Toric, Monthly, Soft Contact Lens in Digital Device Users.

Purpose: To determine the performance of TOTAL30 for Astigmatism (T30fA; Alcon; Fort Worth, TX, USA) contact lenses (CLs) in existing CL wearers who are also frequent digital device users.

Methods: This 1-month, 3-visit study recruited adult, 18- to 40-year-old subjects who were required to use daily digital devices for at least 8 hours per day. All subjects were refit into T30fA CLs.

Clinical and Radiographic Evaluation between Conventional Mineral Trioxide Aggregate and Gel-based Mineral Trioxide Aggregate in Indirect Pulp Therapy: A Randomized Clinical Trial.

Background: Indirect pulp treatment (IPT) is often employed in dentistry as a valuable technique for preserving dental vitality. While mineral trioxide aggregate (MTA) remains a popular choice, the need for materials with shorter setting times, lower costs, and minimized discoloration concerns has led to the exploration of alternative options.

Aim: To evaluate and compare the radiographic and clinical outcomes of gel-based MTA Kids e-MTA (Kids-e-Dental, Mumbai, India) with MTA (ProRoot MTA, Dentsply Tulsa, Johnson City, TN, USA).

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.

Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. Osteoclast-directed resorption and osteoblast-directed formation of bone are essential to bone remodeling, and the crosstalk between these cells is vital to curating a sequence of events that culminate in the creation of bone tissue.

Resolving inconsistencies between Plötz's descriptions and presumed type specimens of some Hesperiidae (Lepidoptera).

Comparing specimens curated in MfN as primary types of Hesperiidae names proposed by Carl Plötz with the original descriptions and unpublished drawings reveals a number of inconsistencies that we address. Lectotypes are designated for Butler, 1877, Plötz, 1881, and Plötz, 1884. Neotypes are designated for Plötz, 1882 and Plötz, 1882.

ChatGPT-4.0 vs. Google: Which Provides More Academic Answers to Patients' Questions on Arthroscopic Meniscus Repair?

Purpose The purpose of this study was to evaluate the ability of a Chat Generative Pre-trained Transformer (ChatGPT) to provide academic answers to frequently asked questions using a comparison with Google web search FAQs and answers. This study attempted to determine what patients ask on Google and ChatGPT and whether ChatGPT and Google provide factual information for patients about arthroscopic meniscus repair. Method A cleanly installed Google Chrome browser and ChatGPT were used to ensure no individual cookies, browsing history, other side data, or sponsored sites.

Case of a Young Male Recruit With Chest Pain Leading to Entry-Level Separation and Career Termination.

This is a case of a young, 20-year-old, male Navy recruit who was admitted to our healthcare facility with intermittent atypical chest pain and limiting exertional symptoms and was diagnosed with myocardial bridging (MB) as the most likely etiology of his chest after the complete cardiac workup, leading to his career limitations due to potential risks. Our patient presented with atypical chest pain and limiting exertional symptoms. Chest pain was non-radiating.

A Novel Approach to Potentially Improving Soft-Tissue Sarcoma Survival: Prophylactic Lung Radiotherapy Inhibits Growth of Lung Metastases and Prolongs Survival in a Murine Soft-Tissue Sarcoma Model.

Background:  Circulating tumor cells and clusters (CTC) from soft-tissue sarcoma (STS) that become entrapped in the lung can form micro-metastases and lead to pulmonary metastatic disease. Many patients with localized high-risk STS later develop metastases. Radiation is effective at reducing local recurrence by eradicating microscopic infiltration and satellites in the reactive zone surrounding the primary tumor.

A Rare Case Report of Extra-adrenal Pheochromocytoma Masquerading as a Pancreatic Head Malignancy.

Extra-adrenal pheochromocytomas are rare neuroendocrine tumors originating outside the adrenal glands and can pose significant diagnostic challenges due to their variable presentations. This report highlights a case of an extra-adrenal pheochromocytoma masquerading as a pancreatic head malignancy. We underscore the importance of considering extra-adrenal pheochromocytoma in the differential diagnosis of pancreatic masses, particularly when biochemical or clinical features suggest catecholamine excess.

Recurrent Bacteremia in the Setting of Pseudomonas Endocarditis of the Tricuspid Valve and Indwelling Medical Devices.

This case report presents a complex and challenging scenario of recurrent () bacteremia and tricuspid valve endocarditis in a 77-year-old male patient with multiple comorbidities and indwelling medical devices. The patient's medical history was significant for T4 paraplegia, neurogenic bladder requiring a chronic indwelling suprapubic catheter, heart block status post-permanent pacemaker placement, type 2 diabetes mellitus, chronic kidney disease, and chronic sacral wounds. The case highlights the difficulties in managing antibiotic-resistant infections, particularly in patients with implantable devices and chronic wounds.

General Versus Interventional Gastroenterologists: A Comparative Analysis of Follow-Up Outcomes After Endoscopic Mucosal Resection of Colorectal Polyps.

Introduction Colorectal cancer (CRC) represents a major global health burden, significantly impacting mortality rates and healthcare systems worldwide. CRC screening through colonoscopy enables early detection and removal of precancerous polyps. While standard polypectomy suffices for small polyps, larger ones require endoscopic mucosal resection (EMR).

Knee Ligament Injuries in the National Football League: Impact of Field Surface Type During the 2020-2023 Seasons.

Introduction A subject of ongoing debate within the National Football League (NFL) community revolves around the comparative risk of anterior cruciate ligament (ACL) injuries on natural versus artificial turf field surfaces. There have been mixed results as to whether there is a difference in injury rates depending on the playing surface and what factors might play a role in affecting these rates. Methods This study aims to compare the incidence of in-game knee ligament tears in the NFL during the 2020-2023 seasons.

Unveiling Lyme Neuroborreliosis in the Absence of Dermatological Symptoms.

Lyme neuroborreliosis can present with isolated neurological manifestations, posing diagnostic challenges, especially in the absence of hallmark dermatological symptoms like erythema migrans. This case highlights a patient with isolated cervical radiculopathy due to Lyme neuroborreliosis, presenting without systemic features such as fever, arthralgia, or rash. The diagnosis was confirmed through serological testing, with positive findings on the Western blot.

Avoidant/Restrictive Food Intake Disorder in a Pediatric Obese Patient.

Avoidant/restrictive food intake disorder (ARFID) can present with limited food variety, intake, or aversions. The symptoms can manifest at any age and typically appear in the first few years of life. The prevalence of ARFID varies widely among clinical and non-clinical populations, and its diagnosis requires trained health professionals to ensure early detection and prevention of poor outcomes.

Rethinking Right Upper Quadrant (RUQ) Pain: The Role of Lemmel Syndrome in Biliary Obstruction.

Lemmel syndrome involves a periampullary duodenal diverticulum (PAD), a pouch-like outpouching near the ampulla of Vater, compressing the common bile duct. We describe a case of severe abdominal pain in a patient who had a large periampullary diverticulum, managed with surgical intervention after an initial failed endoscopic retrograde cholangiopancreatography (ERCP). An elderly female patient in her early 90s arrived at the emergency department with severe cramping pain localized to the right upper quadrant of her abdomen, progressively intensifying over several weeks.

Managing Non-islet Cell Tumor Hypoglycemia in Hepatocellular Carcinoma With Radiation Therapy.

Non-islet cell tumor hypoglycemia (NICTH) is a paraneoplastic syndrome associated with non-mesenchymal-derived and epithelial tumors. A 37-year-old male with stage IVB hepatocellular carcinoma (HCC) and pulmonary metastases presented with recurrent hypoglycemia despite glucose supplementation. Laboratory findings revealed low insulin growth factor 1 (IGF-1) (15 ng/mL), elevated insulin growth factor 2 (IGF-2) (395 ng/ml), and an IGF-2:IGF-1 ratio of 26:1, consistent with NICTH.

Enhancing Cervical Foraminotomy Outcomes With Patient-Specific 3D Anatomical Models: A Comparative Study.

Introduction: Cervical foraminotomy is a procedure used to treat patients with radiculopathy. While the procedure can be performed using a minimally invasive technique, achieving complete visualization of relevant anatomy can be challenging. This study explores the use of patient-specific three-dimensional (3D) printed anatomical models, created from advanced medical imaging data, for preoperative planning and intraoperative guidance in cervical foraminotomy by comparing fluoroscopy time, operative time, estimated blood loss volume, and functional improvement.

A Case of Lepromatous Leprosy Presenting With Multiple Morphologies in Philadelphia.

Leprosy is an uncommon chronic mycobacterial infection in the United States caused by . There are two major forms of the infection, lepromatous leprosy and tuberculoid leprosy, with borderline forms of each. Leprosy is even more uncommon in the Northeastern United States and can present with various symptoms and skin findings, including erythematous or hypopigmented patches or plaques with accompanying hypoesthesia or anesthesia, anhidrosis, or alopecia.

Continuation Versus Interruption of Anticoagulation During Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis.

Transcatheter aortic valve implantation (TAVI) involves complex decisions regarding perioperative anticoagulation, with continuation or interruption of oral anticoagulation presenting distinct risks and benefits. This systematic review and meta-analysis compared the clinical outcomes of these two strategies during TAVI. We conducted a comprehensive literature search across multiple electronic databases, including PubMed, Embase, Cochrane Library, and Web of Science, from inception to November 2024.

Pediatric Rectal Prolapse: A Case Report.

In the absence of preexisting conditions, rectal prolapse is rarely seen in children older than four years old. This case report presents a peculiar instance involving a previously healthy five-year-old female who presented to the clinic with her parents due to a three-day history of constipation, hard stools, and painful defecation. Physical examination revealed a rectal prolapse.

Multidisciplinary Management of Complex Trauma and Burn Injuries: A Case Series of Challenging Clinical Scenarios.

Trauma and burn injuries often present with multiple complications, necessitating a coordinated, multidisciplinary approach to management. This case series reviews the outcomes and challenges of treating high-risk trauma and burn patients, with a focus on complex polytrauma, alcohol withdrawal, high-voltage electrical injuries, and lightning strikes. Each case underscores the importance of early intervention, multidisciplinary team involvement, and individualized treatment protocols for improving patient outcomes in critically injured burn victims.

Trauma-Associated Pseudo-Hutchinson Sign: An Autobiographical Case Report Emphasizing Conditions, Pseudo-Conditions, and Pseudo-Pseudo-Conditions.

Melanonychia describes black pigmentation of the nail plate that results from either melanocyte activation (such as infections, local inflammatory disorders, local trauma affecting the nail plate, numerous systemic conditions, and medications) or melanocyte hyperplasia (such as benign neoplasms or malignant tumors) or blood (resulting from a trauma-associated subungual hematoma). The black dyschromia may include not only the nail plate but also the proximal nailfold. The Hutchinson sign refers to black discoloration of both the proximal nailfold and adjacent nail plate when the underlying pigmented lesion is a malignant melanoma.

Transverse Myelitis in a Healthy Patient With Benign Paroxysmal Positional Vertigo: A Case Report Highlighting Inpatient Rehabilitation and Functional Gains.

Transverse myelitis (TM), a poorly understood neurological disorder, can manifest in various clinical scenarios. We report a unique case where TM presented in a background of benign paroxysmal positional vertigo (BPPV). The patient, an otherwise healthy female, experienced a rapid onset of symptoms, culminating in complete left-sided hemiparesis and exacerbation of BPPV characteristics.

Adolescents' Diabetes Self-Management Regimens and Outcomes During the COVID-19 Pandemic: A Scoping Review.

Adolescents with diabetes mellitus (DM) experience poorer glycemic outcomes and lower adherence to self-management regimens compared to other age groups. The coronavirus 2019 (COVID-19) pandemic posed new barriers to DM self-management, including social distancing measures and additional stressors. We conducted a scoping review of peer-reviewed literature to examine self-management regimens and outcomes among adolescents aged 10-17 years with type 1 and type 2 DM during the pandemic.

Addressing Drug Shortages at Mediclinic Parkview Hospital: A ‎Five-Year Study of ‎Challenges, Impact, and Strategies.

Background Drug shortages have become a significant challenge globally, affecting healthcare delivery and patient outcomes. This study aimed to assess drug shortages' prevalence, causes, and impact at a tertiary care hospital in Dubai, the United Arab Emirates (UAE), providing actionable insights for future mitigation strategies. Methods A retrospective descriptive study was conducted at Mediclinic Parkview (MPAR) Hospital, part of Mediclinic Middle East (MCME), UAE.

Technological Advancements in Augmented, Mixed, and Virtual Reality Technologies for Surgery: A Systematic Review.

Recent advancements in artificial intelligence (AI) have shown significant potential in the medical field, although many applications are still in the research phase. This paper provides a comprehensive review of advancements in augmented reality (AR), mixed reality (MR), and virtual reality (VR) for surgical applications from 2019 to 2024 to accelerate the transition of AI from the research to the clinical phase. This paper also provides an overview of proposed databases for further use in extended reality (XR), which includes AR, MR, and VR, as well as a summary of typical research applications involving XR in surgical practices.