Interfacial electromigration for accelerated reactions.

Background: Microdroplets have emerged as effective confined-volume reactors due to their remarkable ability to accelerate chemical reactions compared to bulk systems. Recent research highlights the crucial role of air-liquid interfaces in this acceleration. A microdroplet can be viewed as having two kinetically distinct regions: the interface and the interior.

One-step colorimetric immunosensing of foodborne bacteria using static magnet driven magnetophoretic separation and dual noble metal decorated magnetic nanobeads.

Background: Immunomagnetic separation is essential for screening pathogenic bacteria to prevent food poisoning. However, free immunomagnetic nanobeads (IMNBs) coexist with IMNB-bacteria conjugates (IBCs) after traditional immunomagnetic separation resulting in the infeasibility for IMNBs on IBCs to further act as signal label in bacterial detection. Although we have demonstrated that magnetophoretic separation at a high flowrate could separate IBCs from IMNBs, partial IMNBs were still found with IBCs due to chaotic flows and resulted in inevitable interferences.

Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo.

Background: The imperative need for early cancer detection, which is crucial for improved survival rates in many severe cancers such as lung cancer, remains challenging due to the lack of reliable early-diagnosis technologies and robust biomarkers. To address this gap, innovative screening platforms are essential to unveil the chemical signatures of lung cancer and its treatments. It is established that the oxidative tumor environment induces alterations in host metabolic processes and influences endogenous volatile synthesis.

Creating a student-led PhD in nursing diversity, equity, and inclusion advisory council.

Background: Challenges arising from the COVID-19 pandemic and social injustice complicated the nursing workforce, nursing education, and personal life inequities faced by Doctor of Philosophy (PhD) in Nursing students from historically marginalized and minoritized communities (MMC). This article describes the process of forming a PhD in Nursing Student-Led Diversity, Equity, and Inclusion (DEI) Advisory Council to address these inequities.

Methods: The authors provide a blueprint for developing a similar group through supporting research and experiences.

Trauma-informed leadership strategies to improve baccalaureate nursing student engagement and well-being.

Trauma-informed leadership is a critical strategy in enhancing nursing student success by fostering a supportive and empowering educational environment. The inclusion of trauma-informed practices in nursing education emphasizes the importance of understanding this generation of students impacted by the COVID-19 pandemic and other potential traumas. Strategies for how trauma-informed leadership was implemented in a baccalaureate nursing program are detailed in this article.

Relationship between social support and psychological distress in nursing students: The mediating role of school-life interference.

Background: Social support is a crucial factor in mitigating psychological distress among nursing students. However, the specific mechanism through which social support influences psychological distress, particularly the mediating role of school-life interference, remains underexplored. Aim The researchers investigated the relationship between social support and psychological distress in nursing students and examined the extent to which school-life interference mediates this relationship.

Paradoxical effect of flipped classroom on nursing students' learning ability and satisfaction in a fundamental of nursing clinical course: A quasi-experimental study.

Background: The "Fundamentals of Nursing" course is crucial for equipping novice undergraduate nursing students with essential skills for their professional practice. However, a gap exists between nursing education and clinical readiness-a challenge exacerbated by the COVID-19 pandemic and issues like absenteeism in clinical sessions. The flipped classroom has been proposed as an innovative strategy to bridge this gap, offering students opportunities for self-paced learning before class and enabling more active, hands-on practice during lab sessions.

Psychological resilience as a mediator between nurse faculty support and student nurses' clinical adjustment: Implications for nursing education.

Background: Nurse faculty play a critical role in shaping the clinical experience of student nurses through their support and guidance during clinical placements. However, despite this evidence, the mechanism by which nurse faculty support contributes to effective clinical adjustment in students remains unexplored.

Purpose: This study examined the intermediary role of psychological resilience in the relationship between nurse faculty support and clinical adjustment among student nurses.

Peaks in weak lensing mass maps for cluster astrophysics and cosmology.

Clusters of galaxies can be identified from the peaks in weak lensing aperture mass maps constructed from weak lensing shear catalogs. Such purely gravitational cluster selection differs considerably from traditional cluster selection based on the baryonic properties of clusters. In this review, we present the basics and applications of weak lensing shear-selected cluster samples.

Computational Modeling Reveals a Catch-and-Guide Interaction Between Kinesin-1 and Tubulin C-Terminal Tails.

The delivery of intracellular cargoes by kinesins is modulated at scales ranging from the geometry of the microtubule networks down to interactions with individual tubulins and their code. The complexity of the tubulin code and the difficulty in directly observing motor-tubulin interactions have hindered progress in pinpointing the precise mechanisms by which kinesin's function is modulated. As one such example, past experiments show that cleaving tubulin C-terminal tails (CTTs) lowers kinesin-1's processivity and velocity on microtubules, but how these CTTs intertwine with kinesin's processive cycle remains unclear.

Physician assessment, comparative abilities and artificial intelligence: implications for informed consent.

While artificial intelligence's (AI's) potential role in enhancing diagnostic accuracy and personalising treatment is well-recognised, its application in evaluating physicians raises critical ethical concerns as well. The paper examines the impact of AI on the 'comparative abilities' exception to informed consent, which currently exempts physicians from disclosing information about the performance of other providers. With AI's ability to generate granular, accurate comparisons of physician metrics, this exception will be challenged, potentially empowering patients to make more informed decisions.

Abortion and infanticide: why the parent-child relationship symmetry breaker fails.

Some pro-life philosophers have argued that if one accepts abortion, one should accept infanticide. Prabhpal Singh has proposed a symmetry breaker. He argues that the parent-child relationship can only be obtained between born humans and such a relationship entails that infanticide is wrong.

Agreement analysis of subjective and objective sleep quality in adolescents with mood disorders.

Objectives: Accurate assessment of sleep quality is crucial for understanding sleep problems and their impact on health. This study analyzed the agreement between subjective sleep assessments and objective sleep monitoring in adolescents with mood disorders, aiming to provide a reliable methodological foundation for related research.

Methods: Adolescents with mood disorders were recruited from psychiatric outpatient clinics of three domestic hospitals.

Testing AuxInYeast Synthetic Biology Strains via Fluorescence Flow Cytometry.

Understanding how the auxin hormone signaling pathway components come together to orchestrate cellular responses is key to engineering the growth and development of maize. Although a variety of techniques exist to measure auxin activities in plants, many are time- and resource-intensive or do not easily allow for high-throughput quantitative measurement of component libraries. The AuxInYeast system is a synthetic biology tool that facilitates complex biochemical analysis of the auxin hormone signaling pathway from essentially any plant.

Building AuxInYeast Synthetic Biology Strains for Biochemical Characterization of Maize Auxin Hormone Signaling Components.

The AuxInYeast system is a synthetic biology tool that facilitates complex biochemical analysis of the plant auxin hormone signaling pathway. As a plant synthetic biology chassis, yeast offers rapid growth, well-established genetic and biochemical tools, and core eukaryotic cellular machinery compatible with heterologous plant gene expression. The AuxInYeast system for maize consists of yeast cells containing the minimal necessary set of plant auxin signaling parts: a receptor (ZmTIR1/AFB), repressor (ZmIAA), corepressor (REL2), transcription factor (ZmARF), and auxin response -element (auxRE).

Synthetic Biology Approaches to Study Maize Signaling Pathways.

Synthetic biology approaches merge the tenets of engineering with established biological techniques to answer fundamental questions about living systems and to engineer biological forms and functions. Following the engineering principle of design-build-test-iterate, this review serves as a guide to applying synthetic principles and approaches in maize. We outline strategies for (1) choosing the optimal model organism to serve as a heterologous chassis for maize signaling pathways, (2) designing and building biological parts and devices to express pathway components, (3) choosing an analytical technique to measure pathway function, and (4) optimizing and troubleshooting the designed system.

Occupational exposure and chronic bronchitis in a sample of the general population in Telemark, Norway: a two-phased cross-sectional study.

Objectives: We aimed to estimate the prevalence of chronic bronchitis (CB), examine its association with occupational exposure to irritants assessed by self-reporting or the Nordic job exposure matrix (N-JEM) stratified by smoking status and estimate the population-attributable fraction (PAF) of CB from occupational exposure.

Methods: A two-phased, cross-sectional design was used to analyse a random sample collected in 2013 and 2018 of the population aged 16-55 years in Telemark County, Norway. CB was defined as cough and sputum production for ≥3 months over 2 consecutive years.

KRAB zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution.

As transposable elements (TEs) coevolved with the host genome, the host genome exploited TEs as functional regulatory elements of gene expression. Here we show that a subset of KRAB domain-containing zinc-finger proteins (KZFPs), which are highly expressed in mitotically dividing spermatogonia, repress the enhancer function of endogenous retroviruses (ERVs) and that the release from KZFP-mediated repression allows activation of ERV enhancers upon entry into meiosis. This regulatory feature is observed for independently evolved KZFPs and ERVs in mice and humans, suggesting evolutionary conservation in mammals.

Self-Perception as a Predictor of Eating Disorder Severity in a Residential Sample of Women and Girls With Eating Disorders.

Eating disorders are serious mental health conditions with significant negative health outcomes, high mortality rates, and comorbid mental health conditions. Despite many available interventions for eating disorders, treatment remains challenging due to the difficulty in maintaining treatment gains. Understanding effective treatment processes is crucial.

Utilizing the Social Ecological Model to Inform Nursing Practice for Improved Childhood Eating Behaviors.

Understanding and promoting healthy eating behaviors in young children is essential for their immediate and long-term health outcomes. However, these behaviors are influenced by an intricate network of factors that extend beyond individual choices, posing challenges for health practitioners seeking effective interventions. This article aims to explore how the Social Ecological Model (SEM) can serve as a framework for understanding the multilevel determinants of young children's eating behaviors, and the seminal role that nursing plays in this dynamic.

Early Mobilization of Patients in the Intensive Care Unit: A Quality Improvement Evidence-Based Project.

At an urban public acute care hospital, a gap existed in the safety and efficacy of early mobilization (EM) of intensive care unit (ICU) patients, with the need for an evidence-based intervention. A literature review revealed that a nurse-driven mobility protocol could safely achieve early mobility in ICU patients. This quality improvement project aims to utilize a nurse-driven mobility protocol to determine its effects on EM of ICU patients.

Understanding stigma as a barrier to cancer prevention and treatment: a qualitative study among people living with HIV in Uganda and Zambia.

Objectives: Extended life expectancy due to treatment improvements has increased the diagnosis of cancer among people living with HIV (PLWH) in Africa. Despite documented impacts of stigma on cancer preventive behaviours and care, little is known about the intersections of cancer and HIV stigma and the effects on prevention and care behaviours for both conditions. This study aims to examine experiences and drivers of cancer stigma and their associations with access to and utilisation of cancer prevention services among PLWH.