Cardiac magnetic resonance imaging in patients with suspected myocarditis from immune checkpoint inhibitor therapy - A real-world observational study.

Background And Aims: Cardiotoxicity from immune checkpoint inhibitor (ICI) therapy is a challenge in clinical practice, and the assessment of ICI-related myocarditis (ICI-M) is often complicated by a variable phenotype. Cardiac magnetic resonance imaging (CMR) is used frequently, but evidence is poor. Here, we aim to assess the role of CMR in the assessment of suspected ICI-M in a real-world clinical setting.

Clinical Hypnosis and Cognitive Behavioral Therapy for Hot Flashes: A Scoping Review.

Background: Hot flashes can be a prevalent issue for postmenopausal women, but traditional treatments such as hormone therapy can have adverse side effects. Recommended psychotherapies for managing hot flashes include cognitive behavioral therapy (CBT) and clinical hypnosis, but an in-depth review comparing the efficacy of both treatments is warranted.

Objectives: The aim of the present scoping review was to assess the clinical significance and efficacy of symptom reduction of CBT and clinical hypnosis as treatments of hot flashes.

Pandemic Impact on Research Faculty in Academic Medicine: A Mixed Method Study.

Introduction: This mixed-method study sought to elucidate the impact of COVID-19 on the professional environments and career trajectories of midcareer research faculty in U.S. medical schools.

Presenting Your Best Self: How Physician Appearance Influences Patient Perceptions and Impacts Women in Medicine.

Introduction: Trust and rapport between patients and physicians form the cornerstone of effective medical practice. A key factor influencing this trust is the patient's perception of the physician's appearance. Women physicians often face more rigorous expectations concerning their physical appearance compared to men physicians, creating a need to balance traditional professional attire with maintaining femininity and individuality.

A database of nutritional strategies of nanoplankton genera present in North American lake surface waters.

A database of nutritional strategies of nanoplankton genera present in North American lake surface waters is presented. This work represents an integrated and updated database of nutritional strategies for nanoplankton genera commonly found in surface waters of North American lakes. We tabulate the nutritional strategies (autotroph, phago-mixotroph and phago-heterotroph) for nanoplankton genera identified during several pan-continental lake surveys: the EPA-NLA surveys conducted in 2012 and 2017 across the continental USA and the NSERC Canadian Lake Pulse survey campaign conducted from 2017 to 2019.

Mineralized tissue loss at the femoral ACL enthesis in young male ACL-injured patients.

Purpose: Primary anterior cruciate ligament (ACL) reconstruction graft failure remains a significant health concern in young patients. Despite the high incidence of poor graft integration in these patients and the resulting high failure rate, little consideration has been given to the quality of the bone into which the graft is anchored at reconstruction. Therefore, we investigated post ACL injury mineralized tissue changes in the ACL femoral entheses of young males and compared them to changes previously reported for young females.

Biophysics-guided uncertainty-aware deep learning uncovers high-affinity plastic-binding peptides.

Plastic pollution, particularly microplastics (MPs), poses a significant global threat to ecosystems and human health, necessitating innovative remediation strategies. Biocompatible and biodegradable plastic-binding peptides (PBPs) offer a potential solution through targeted adsorption and subsequent MP detection or removal from the environment. A challenge in discovering plastic-binding peptides is the vast combinatorial space of possible peptides (, over 10 for 12-mer peptides), which far exceeds the sample sizes typically reachable by experiments or biophysics-based computational methods.

High-risk electrocardiogram presentations in the acute coronary syndrome patient - Beyond ST-segment elevation myocardial infarction.

This review considers high-risk electrocardiographic patterns in the acute coronary syndrome (ACS) patient; we review 7 electrocardiogram presentations lacking diagnostic criteria for ST-segment elevation myocardial infarction (STEMI) yet likely representing either STEMI equivalent syndromes or ACS presentations with significant short-and long-term risk. The STEMI equivalent presentations include acute posterior wall myocardial infarction, the hyperacute T-wave of early STEMI, de Winter syndrome, first diagonal of the left anterior descending artery occlusion, and left bundle branch block modified Sgarbossa positive findings. High-risk presentation, not felt to be STEMI equivalent entities yet still possessing significant risk of short-and long-term adverse outcome, include lead aVR ST-segment elevation and Wellens syndrome.

'Any male victim?' The legacy of conflating paedophilia and homosexuality and the differential seriousness of sexual abuse by victim gender.

This article presents the findings of a historical, qualitative thematic analysis of archival clinical records of 24 men convicted of child sexual abuse and referred for civil commitment to the Massachusetts Treatment Center between 1959 and 1984. Drawing on the perspective of Cicourel, the study examined the differential ways men convicted of child sexual abuse were constructed by various criminal justice actors based on the gender of their victims. Overall, the study found that men with male victims were constructed as more deviant than men with female victims.

A comprehensive mechanistic investigation of sustainable carbene N-H insertion catalyzed by engineered His-ligated heme proteins.

Engineered heme proteins possess excellent biocatalytic carbene N-H insertion abilities for sustainable synthesis, and most of them have His as the Fe axial ligand. However, information on the basic reaction mechanisms is limited, and ground states of heme carbenes involved in the prior computational mechanistic studies are under debate. A comprehensive quantum chemical reaction pathway study was performed for the heme model with a His analogue as the axial ligand and carbene from the widely used precursor ethyl diazoacetate with aniline as the substrate.

Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer.

This study evaluates the effects of hydroxytyrosol (HT), a component of olive oil, on mammographic breast density reduction. We explored effects of HT on Wnt -catenin and other pathways involved in cancer stem cell renewal, DNA repair, cell proliferation, and differentiation. Twenty-five milligrams per day oral dose of HT was given for 12 months in pre- and postmenopausal women at increased risk of breast cancer.

Theta and beta power in the subthalamic nucleus responds to conflict across subregions and hemispheres.

The subthalamic nucleus is thought to play a crucial role in controlling impulsive actions. Networked among the basal ganglia and receiving input from several cortical areas, the subthalamic nucleus is well positioned to influence action selection when faced with competing and conflicting action outcomes. The purpose of this study was to test the dissociable roles of the dorsal and ventral aspects of the subthalamic nucleus during action conflict in patients with Parkinson's disease undergoing intraoperative neurophysiological recording and to explore a potential mechanism for this inhibitory control.

Dehydroamino acids and their crosslinks in Alzheimer's disease aggregates.

Alzheimer's disease (AD) is characterized by the accumulation of protein aggregates, which are thought to be influenced by posttranslational modifications (PTMs). Dehydroamino acids (DHAAs) are rarely observed PTMs that contain an electrophilic alkene capable of forming protein-protein crosslinks, which may lead to protein aggregation. We report here the discovery of DHAAs in the protein aggregates from AD, constituting an unknown and previously unsuspected source of extensive proteomic complexity.

Assessing the costs and savings of telemedicine: Insights from the consolidated framework for implementation research.

Cost reduction is an often-cited reason to use telemedicine. In assessing telemedicine's cost and value, providers often turn to published cost analyses in the scientific literature for guidance. In this commentary on existing telemedicine cost analysis literature, we discuss the generalizability of these analyses and identify the Consolidated Framework for Implementation Research framework to help assess the applicability of a given cost analysis using inner- and outer-setting constructs.

Optimizing Clinical Postgraduate Training: Perspectives of Postgraduate Alumni Regarding Their Residency Training at Mbarara University of Science and Technology, Uganda.

Background: Understanding alumni satisfaction and the competencies gained during university training can guide improvements in education quality, particularly in higher education institutions. This study at Mbarara University of Science and Technology (MUST) explored the factors influencing alumni decisions, their residency experiences, and their levels of satisfaction. Additionally, it provided recommendations for improving graduate training programs.

Harnessing Terbium Radioisotopes for Clinical Advancements: A Systematic Review.

Background this systematic review was conducted to assess the practical application of terbium radioisotopes, utilizing systematic search methodologies to identify relevant studies. Methods the databases of PubMed, Web of Science, and Scopus were systematically scoured, targeting the research on four terbium isotopes:  Tb,  Tb,  Tb, and  Tb. Various combinations of keywords related to terbium and its four radioisotopes were used in the search process.

Not getting better but not getting worse: A cluster randomized controlled pilot trial of a leadership implementation strategy.

Background: Implementation of evidence-based practices (EBPs) in schools is fraught with challenges. Even when EBPs are initiated, deterioration of implementation efforts often hinders their long-term success. School leadership behaviors can influence teachers' EBP implementation.

Remodeling of ER Membrane Contact Sites During Cell Division.

Membrane contact sites (MCS) provide specialized conduits for inter-organelle communications to maintain cellular homeostasis. Most organelles are interconnected, which supports their coordination and function. M-phase (mitosis or meiosis) is associated with dramatic cellular remodeling to support cell division, including the equal distribution of organelles to the two daughter cells.

Clinical Use of Dostarlimab in Advanced Stage and Recurrent Endometrial Cancer: Patient Selection and Perspectives.

Endometrial cancer (EC) is the most common gynecologic cancer in developed nations with reported 420,368 new cases worldwide in 2022 and resulting in 97,723 deaths that year; it is also one of the few cancers with expected increases in incidence and mortality, which are expected to increase by 50% and 70%, respectively, by 2045. The mortality from EC can largely be attributed to the advanced stage and recurrent cases. Over the past decade, the standard of care for treatment of primary advanced stage and recurrent EC has been chemotherapy, resulting in a median overall survival (OS) of less than 3 years.

Effectiveness of Treating Vertical Maxillary Excess Among Non-growing Adult Patients With Skeletal Anchorage System: A Systematic Review and Meta-Analysis of Case Reports From 2008 to 2023.

Vertical maxillary excess presents a complex challenge in orthodontic treatment, necessitating effective anchorage systems for optimal correction. This research is useful to assess the skeletal anchorage system's (SAS) effectiveness in correcting the vertical maxillary excess among adult patients presenting with gummy smiles. This study includes case reports with English full text and examines the global general adult (18+) human population with vertical maxillary excess (VME).

Mechanical Considerations and Clinical Implications of Joint Arthroplasty Metallosis.

The treatment for osteoarthritis (OA) often requires total joint arthroplasty (TJA) when less invasive approaches fail. The annual incidence of TJA is rising. Metal-on-metal (MoM) hip and knee implants were widely used for TJA in the past, but complications have led to their decline.

A Case of Subungual Exostosis Mimicking Verruca Vulgaris.

Subungual exostosis is a benign bone tumor causing nail deformities and possibly pain for the patient. Etiology includes trauma, infection, and activation of a cartilaginous cyst, more commonly seen in adult patients. Here, we present a case of subungual exostosis in a pediatric patient that initially mimicked subungual verruca vulgaris.

A Case of a Short Stature Patient With Marfan Syndrome: A Tale of Wide Mediastinum.

Marfan syndrome (MFS), an inherited connective tissue disorder, is caused by a mutation in the FBN1 gene. MFS is characterized by complex manifestations involving musculoskeletal, cardiovascular, and ocular systems. The usual presentation for suspecting diagnosis in an individual with aortic root disease is tall stature in addition to other features that fulfill Ghent criteria.