5,620,129 results match your criteria: "USA; The Ohio State University Wexner Medical Center[Affiliation]"
Curr Microbiol
January 2025
Coastar Therapeutics, San Diego, CA, 92126, USA.
Staphylococcus epidermidis (S. epidermidis) live in different human locations and natural environments. For ribotyping S.
View Article and Find Full Text PDFTher Innov Regul Sci
January 2025
Bayer US LLC, Whippany, NJ, USA.
Background: Clinical outcome assessments (COAs) measure how patients feel or function and can be used to understand which patients experience benefits of treatment and which do not. Interpretation of COA data is influenced by how meaningful change is defined. We aimed to compare how different stakeholders define, assess, and use meaningful change for decisions that impact patients.
View Article and Find Full Text PDFJ Hist Biol
January 2025
Department of the History and Sociology of Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.
This paper explores the control of visiting "foreign scientists" at the Charles Darwin Research Station (CDRS) after it was established in the Galápagos Islands in 1959. Scholarly accounts of the creation of the Galápagos National Park and of the field station have emphasized their place in an international "land grab," as leading scientists and conservationists sought to control nature in places around the world that seemed less "civilized" to European thinkers. The actual administrative labor in the early years at this scientific field station, however, in practice struggled to control people widely taken to represent "civilization" in its highest form-European and American scientists.
View Article and Find Full Text PDFCurr Cardiol Rep
January 2025
Department of Zoology, Trivenidevi Bhalotia College (Affiliated to Kazi Nazrul University), College Para Rd, Raniganj, 713347, West Bengal, India.
Purpose Of Review: This review investigates how post-injury cellular signaling and energy metabolism are two pivotal points in zebrafish's cardiomyocyte cell cycle re-entry and proliferation. It seeks to highlight the probable mechanism of action in proliferative cardiomyocytes compared to mammals and identify gaps in the current understanding of metabolic regulation of cardiac regeneration.
Recent Findings: Metabolic substrate changes after birth correlate with reduced cardiomyocyte proliferation in mammals.
Arch Dermatol Res
January 2025
Department of Dermatology, Massachusetts General Hospital, 50 Staniford St., Boston, MA, 02114, USA.
Arch Dermatol Res
January 2025
Division of Dermatology, Department of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
Cancer Chemother Pharmacol
January 2025
Institute of Medicine, Chung-Shan Medical University, Taichung, 40201, Taiwan.
Objective: Based on our previous research, which demonstrated that elevated plasma endoglin (ENG) levels in lung cancer patients were associated with a better prognosis, increased sensitivity to pemetrexed, and enhanced tumor suppression, this study aims to validate these findings at the cellular level. The focus is on membrane and extracellular ENG and their influence on drug response and tumor cell behavior in non-small cell lung cancer (NSCLC) cells.
Methods: The correlation between ENG expression and pemetrexed-induced cytotoxicity in eight human non-squamous subtype NSCLC cell lines was analyzed.
Arch Dermatol Res
January 2025
Department of Dermatology, Oregon Health & Science University, 3303 S Bond Ave Building 1, 16th floor, Portland, OR, 97239, USA.
Eur Spine J
January 2025
Department of Neurosurgery, University of Arizona College of Medicine, 1111 Mc Dowell Road, Phoenix, AZ, 85006, USA.
Purpose: An atypical presentation of cervical spondylopathy (CS), trigeminal neuralgia (TN) is attributable to the extension of trigeminal nuclei into the spinal cord and is frequently overlooked, leading to limited discussion with patients regarding potential anterior cervical surgery. Our systematic review assesses the effectiveness of cervical surgery for concurrent trigeminal neuralgia in cases of cervical spondylopathy.
Methods: A systematic review exploring cases of trigeminal neuralgia related to cervical spondylopathy was conducted searching on PubMed, Scopus and Embase databases for article in English.
Arch Dermatol Res
January 2025
Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA, 02115, USA.
Am J Physiol Renal Physiol
January 2025
Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Aims: Whether prior treatment with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) modifies efficacy and safety of sacubitril/valsartan (Sac/Val) in patients with heart failure (HF) and ejection fraction (EF) >40% is unclear, thus Sac/Val according to ACEi/ARB status at baseline was assessed.
Methods And Results: This was a pre-specified analysis of Prospective comparison of ARNI with ARB Given following stabiLization In DEcompensated HFpEF (PARAGLIDE-HF), a double-blind, randomized controlled trial of Sac/Val versus valsartan, categorizing patients according to baseline ACEi/ARB status. The primary endpoint was time-averaged proportional change in N-terminal pro-B-type natriuretic peptide (NT-proBNP) from baseline through weeks 4 and 8.
J Man Manip Ther
January 2025
Department of Physical Therapy, Baylor University, Waco, TX, USA.
Objective: To investigate physical therapist adherence to the Academy of Orthopaedic Physical Therapy's (AOPT) clinical practice guidelines (CPGs) for the management of neck and low back pain (LBP) and to compare adherence among varying clinical specializations.
Design: Electronic cross-sectional survey.
Methods: The survey was sent to 17,348 AOPT members and 7,000 American Academy of Orthopaedic Manual Physical Therapists (AAOMPT) members.
Am J Physiol Endocrinol Metab
January 2025
Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239.
Maternal obesity puts the offspring at high risk of developing obesity and cardio-metabolic diseases in adulthood. Here, we utilized a mouse model of maternal high-fat diet (HFD)-induced obesity that recapitulates metabolic perturbations seen in humans. We show increased adiposity in the offspring of HFD-fed mothers (Off-HFD) when compared to the offspring regular diet-fed mothers (Off-RD).
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Macromolecular Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44122, USA.
Data-driven techniques, such as proper orthogonal decomposition (POD) and uniform manifold approximation & projection (UMAP), are powerful methods for understanding polymer behavior in complex systems that extend beyond ideal conditions. They are based on the principle that low-dimensional behaviors are often embedded within the structure and dynamics of complex systems. Here, the internal motions of a thermoresponsive, LCST polymer are investigated for two cases: (1) the coil-to-globule transition that occurs as the system is heated above its critical temperature and (2) intramolecularly crosslinked, single chain nanoparticles (SCNPs) both above and below the critical temperature ().
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Purpose: Alteration of visual acuity in wet age-related macular degeneration (AMD) is mostly driven by vascular endothelial growth factor A (VEGF-A)-induced edema from leaky newly forming blood vessels below the retina layers. To date, all therapies aimed at alleviation of this process have relied on inhibition of VEGF-A activity. Although effective in preventing vascular leak and edema, this approach also leads to the loss of normal vasculature and multiple related side effects.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Purpose: Uncorrected visual impairment (VI) significantly impacts life quality and exacerbates age-related health issues. Social determinants of health (SDOH) are associated with uncorrected VI, but quantitative evidence is limited. This study investigated the link between SDOH and uncorrected VI among aging adults to identify disparities and improve vision care.
View Article and Find Full Text PDFTransl Vis Sci Technol
January 2025
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Purpose: Geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD), has limited treatment options. This study introduces a novel mouse model featuring an expanding GA patch that can be used to test mechanisms and therapeutics.
Methods: C57Bl/6J male mice (n = 96) aged 9-10 weeks received an intraperitoneal (IP) injection of 20 mg/kg sodium iodate (NaIO3).
J Natl Cancer Inst
January 2025
Division of Pediatric Hematology & Oncology, University of Minnesota, Minneapolis, MN, USA.
Purpose: It is not known whether temporal changes in childhood cancer therapy have reduced risk of subsequent malignant neoplasms (SMNs) of the central nervous system (CNS), a frequently fatal late effect of cancer therapy.
Methods: Five-year survivors of primary childhood cancers diagnosed between 1970-1999 in the Childhood Cancer Survivor Study with a subsequent CNS SMN were identified. Cumulative incidence rates and standardized incidence ratios (SIR) were compared among survivors diagnosed between 1970-1979 (N = 6223), 1980-1989 (N = 9680), and 1990-1999 (N = 8999).
Rheumatology (Oxford)
January 2025
Amgen Inc, Thousand Oaks, CA, USA.
Objectives: Long-term maintenance of serum urate (SU) levels <6 mg/dl reduces gout flare frequency. However, urate-lowering therapy (ULT) initiation can induce gout flare. The incidence of thromboembolic (TE) and cardiovascular (CV) events has been shown to increase in the 30 and 120 days following gout flare, respectively; therefore, the question of ULT initiation increasing patient risk for CV/TE events has been raised.
View Article and Find Full Text PDFToxicol Sci
January 2025
ToxStrategies LLC, Austin, Texas, USA.
Traditional approaches for quantitatively characterizing uncertainty in risk assessment require adaptation to accommodate increased reliance on observational (vs. experimental) studies in developing toxicity values. Herein, a case study with PFOA and PFOS and vaccine response explores approaches for qualitative and-where possible-quantitative assessments of uncertainty at each step in the toxicity value development process when using observational data, including review and appraisal of individual studies, candidate study selection, dose-response modeling, and application of uncertainty factors.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Department of Biology, Appalachian State University, Boone, North Carolina, USA.
Unlabelled: Testing for the causative agent of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been crucial in tracking disease spread and informing public health decisions. Wastewater-based epidemiology has helped to alleviate some of the strain of testing through broader, population-level surveillance, and has been applied widely on college campuses. However, questions remain about the impact of various sampling methods, target types, environmental factors, and infrastructure variables on SARS-CoV-2 detection.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
is a vector of several human pathogens in the United States, including the cause of Lyme disease, and Powassan virus (POWV), an emerging cause of severe encephalitis. Skin biopsies from tick bite sites are frequently collected and tested for the presence of spirochetes ( spp.), which remain elusive.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
Center for Acoustics Research and Education, University of New Hampshire, Durham, New Hampshire 03823, USA.
Fishes and aquatic invertebrates utilize acoustic particle motion for hearing, and some additionally detect sound pressure. Yet, few underwater soundscapes studies report particle motion, which is often assumed to scale predictably with pressure in offshore habitats. This relationship does not always exist for low frequencies or near reflective boundaries.
View Article and Find Full Text PDFJASA Express Lett
January 2025
Department of Architectural Engineering, The Pennsylvania State University, 104 Engineering Unit A, University Park, Pennsylvania 16802,
Designers are increasingly tasked to reduce the carbon footprint of buildings. While core disciplines (e.g.
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