Labial Melanotic Macules in Two Pediatric Patients of Chinese Descent With Atopic Dermatitis.

We report two pediatric patients of Chinese descent with atopic dermatitis (AD) who developed labial melanotic macules in the absence of previous topical calcineurin inhibitor (TCI) usage. Both patients presented with multiple hyperpigmented macules on the upper and lower vermilion lips with a negative genetic workup for Peutz-Jeghers. These findings suggest labial melanotic macules may be a cutaneous manifestation of chronic eczematous dermatitis in pediatric patients, particularly those of Asian descent.

Circulating concentrations of vitamins C, D and E vary with age but not with pneumonia status in foals during the first 5 months of life.

Background: Adequate vitamin availability is vital for cellular and immune function and for normal growth. Available data on age-related changes in serum concentrations of vitamins in foals are limited. In addition, associations between circulating vitamin concentrations and the development of bronchopneumonia in foals are not described.

Nurse Practitioner Care Environments and Provider Shortages Among Patients With Multiple Chronic Conditions.

In health professional shortage areas (HPSAs), primary care providers face challenges due to high workloads and limited resources, impacting their ability to provide comprehensive care to patients with multiple chronic conditions (MCCs). In addition, patients in HPSA compared to non-HPSA settings experience poorer outcomes. Nurse practitioners (NPs) play a crucial role in meeting MCC patients' needs, but some work in unfavorable care environments (e.

Behavioral mechanisms of oxycodone's effects in female and male rats: II. Reinforcement magnitude and implications for impulsive/risky choice.

Rats responded under a concurrent-chains procedure wherein reinforcement magnitude was varied within sessions and oxycodone's effects on sensitivity to magnitude were evaluated in two experiments. In Experiment 1, the alternative providing the larger magnitude was signaled and effects of acute (0.1-1.

Objective assessment of acute pain in foals using a facial expression-based pain scale.

Background: Pain assessment based on facial expressions has been described in foals.

Objectives: To extend previous pilot findings of the Equine Utrecht University Scale for Facial Assessment of Pain in Foals (EQUUS-FAP FOAL).

Study Design: Prospective blinded case-control study (known groups analysis).

Outcomes of bio-psycho-social-spiritual community-based drug rehabilitation program for voluntary vs. court-mandated clients in the Philippines.

This study sought to evaluate the outcomes of a community-based rehabilitation program for voluntary and court-mandated drug users in the Philippines. Participants went through a bio-psycho-social-spiritual group-based program that aimed to develop their recovery skills and life skills. The program also included family modules to enhance their knowledge of drug use, its effects, and the role of family in recovery.

Ozone as a method for decontamination of dissolving microneedles for clinical use.

Dissolving microneedles (DMNs) is a promising technology for transdermal and intradermal drug delivery. However, effective decontamination protocols are necessary to ensure safety and efficacy in clinical applications. The challenge is to use a technique that preserves mechanical properties, does not introduce chemicals, and can decontaminate DMNs without affecting the drug.

Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis.

We assessed STAT activation in T cells in blood and skin of AD patients versus HC. pSTAT5 T cells were increased in AD blood, correlated with disease activity, and were induced by common γc cytokines. Skin T cells exhibited a STAT6 signature, whereas only a subset was positive for STAT5.

Jointly modeling responses and omitted items by a competing risk model: A survival analysis approach.

Item response theory models are commonly adopted in educational assessment and psychological measurement. Such models need to be modified to accommodate practical situations when statistical sampling assumptions are violated. Omission is a common phenomenon in educational testing.

Evaluation of plasma alpha-1-antichymotrypsin as a marker for pulmonary Kaposi sarcoma.

Individuals with AIDS and Kaposi sarcoma (AIDS-KS) with pulmonary involvement have high-risk of poor outcomes but diagnosis of pulmonary KS in low-resource settings is difficult. We aimed to discover plasma proteins that distinguish individuals with pulmonary KS from those without pulmonary involvement. SomaScan proteomics screen measured 7288 plasma proteins in 22 cases and 17 controls selected from 181 participants with HIV-1 and cutaneous KS who underwent bronchoscopy.

The Effect of Sex Hormones on Joint Ligament Properties: A Systematic Review and Meta-analysis.

Background: Sex differences exist in injury rates, and one contributing factor may be sex hormone effects on the musculoskeletal system.

Purpose/hypothesis: The goal of this systematic review and meta-analysis was to understand the effects of sex hormones on ligaments in females as determined by preclinical and clinical studies. The hypothesis was that sex hormones would affect ligament mechanical properties, histological features, cellular function, and clinically measurable outcomes.

California annual grass phenology and allometry influence ecosystem dynamics and fire regime in a vegetation demography model.

Grass-dominated ecosystems cover wide areas of the land surface yet have received far less attention from the Earth System Model (ESM) community. This limits model projections of ecosystem dynamics in response to global change and coupled vegetation-climate dynamics. We used the Functionally Assembled Terrestrial Ecosystem Simulator (FATES), a dynamic vegetation demography model, to determine ecosystem sensitivity to alternate, observed grass allometries and biophysical traits, and evaluated model performance in capturing California C annual grasslands structure and fire regimes.

Modeling cardiac contractile cooperativity across species.

Phan and Fitzsimons (https://doi.org/10.1085/jgp.

Habitat engineering by an apex predator generates spatial trophic dynamics across a temporal environmental stress gradient.

Ecosystem engineering is a facilitative interaction that generates bottom-up extrinsic variability that may increase species coexistence, particularly along a stress/disturbance gradient. American alligators (Alligator mississippiensis) create and maintain 'alligator ponds' that serve as dry-season refuges for other animals. During seasonal water recession, these ponds present an opportunity to examine predictions of the stress-gradient (SGH) and intermediate disturbance hypotheses (IDH).

Adolescent health behavior profiles and associations with mental health in a longitudinal study.

To characterize adolescent health behavior profiles and associations with mental health, mixture models using data from two assessment points ( = 201; Female = 53.7%, Time 1 -age = 15.4 years; Time 2 -age = 16.

Body composition alterations in patients with lung cancer.

Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because most studies have been cross-sectional, comparing patients with non-cancer controls or patients with and without CC. Few studies, in contrast, have evaluated body composition in patients with lung cancer over time.

MC16 promotes mitochondrial biogenesis and ameliorates acute and diabetic nephropathy.

Background And Purpose: Kidney disease (KD) is a leading cause of mortality worldwide, affecting 〉10% of the global population. Two of the most common causes of KD are diabetes and acute kidney injury (AKI), both of which induce mitochondrial dysfunction resulting in renal proximal tubular damage/necrosis. Thus, pharmacological induction of mitochondrial biogenesis (MB) may provide a therapeutic strategy to block the onset/progression of KD.

The changing biodiversity of the Arctic flora in the Anthropocene.

The plants of the circumpolar Arctic occupy a dynamic system that has been shaped by glacial cycles and climate change on evolutionary timescales. Yet rapid climatic change can compromise the floristic diversity of the tundra, and the ecological and evolutionary changes in the Arctic from anthropogenic forces remain understudied. In this review, we synthesize knowledge of Arctic floral biodiversity across the entirety of the region within the context of its climatic history.

The impact of a personal cancer diagnosis on adolescent and young adult cancer survivors' social connectedness: A qualitative analysis.

Adolescent/young adult cancer survivors (AYACS) are diagnosed with cancer between 15 and 39 years of age. Improving AYACS' survivorship quality is crucial-including improving social connectedness, a construct describing the quality, structure and function of social relationships. With better understanding of AYACS' social connectedness, network-based interventions can be developed to foster social health.

The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [C]Binimetinib 45 mg in Healthy Male Participants.

Binimetinib is a MEK1/2 inhibitor particularly active in cells harboring activating mutations in the MAP kinase pathway, especially in BRAF and NRAS. Binimetinib, in combination with encorafenib, has received marketing approval in several jurisdictions for the treatment of patients with BRAF V600E or V600K mutant melanoma. The absorption, distribution, metabolism, and excretion of binimetinib were evaluated by administering a carbon 14-labeled binimetinib 45 mg dose (containing 40 μCi of radiolabeled material) to 6 healthy male participants.

Identification of the Novel HLA-DPB1*1483:01 Allele in a Deceased Hispanic/Latino Donor.

We describe the novel HLA-DPB1*1483:01 allele found in a deceased Hispanic/Latino male.

3D Printed Spectroelectrochemical Platform for Redox-Based Bioelectronics.

Redox provides unique opportunities for interconverting molecular/biological information into electronic signals. Here, the fabrication of a 3D-printed multiwell device that can be interfaced into existing laboratory instruments (e.g.