5,627,656 results match your criteria: "USA; Novartis Institutes for Biomedical Research[Affiliation]"
Expert Rev Respir Med
January 2025
Division of Pulmonary & Critical Care Medicine, Mayo Clinic, Rochester MN, USA.
Introduction: Amyloidosis, a polymeric deposition disease classified according to protein subtype, may have varied pulmonary manifestations. Its anatomic-radiologic phenotypes include nodular, cystic, alveolar-septal, and tracheobronchial forms. Clinical presentation may range from asymptomatic parenchymal nodules to respiratory failure from diffuse parenchymal infiltration or diaphragmatic deposition.
View Article and Find Full Text PDFBrain Inj
January 2025
Department of Biomedical Science and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, USA.
Background: Chronic neurologic deficits from traumatic brain injury (TBI) and subsequent infectious encephalitis are poorly characterized.
Methods: Using TriNetX database we queried patients 18 years or older with a confirmed diagnosis of encephalitis between 2016 and 2024. Patient cohorts included those with a diagnosis of TBI at least one month before encephalitis ( = 1,038), those with a diagnosis of a TBI anytime before encephalitis ( = 1,886), and those with encephalitis but no TBI, ( = 45,210; = 45,215).
Dev Dyn
January 2025
Department of Medicine, Michigan State University College of Human Medicine, East Lansing, Michigan, USA.
Disruption of extracellular pH and proton-sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH-sensitive fluorescent protein pHluorin2, tethered to the extracellular face of the plasma membrane using a glycosylphosphatidylinositol (GPI) anchor. Monitoring of pHluorin2 with ratiometric fluorescence revealed dynamic and discrete domains of extracellular acidification over the first 72 h of embryonic development.
View Article and Find Full Text PDFOphthalmic Plast Reconstr Surg
January 2025
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
A 73-year-old male with a history of incidentally diagnosed Paget disease of bone affecting the skull and left orbit 2 years prior presented with 3 months of vision loss, proptosis, and periorbital swelling of the OS. Examination showed best-corrected Snellen visual acuity of 20/150 in the affected eye, intact motility, 7 mm of relative proptosis, significant dilated and tortuous "corkscrew" conjunctival vessels, serous choroidal and retinal detachments, optic nerve hyperemia, and venous tortuosity and dilation. Although the bony lesions in the left orbit were stable from 1 year prior on imaging, the diagnostic angiogram demonstrated osseous blush and hypervascularity of the lesion.
View Article and Find Full Text PDFJ Biomech Eng
January 2025
Department of Mechanical and Industrial Engineering, Northeastern University, 360 Huntington Avenue, Boston, MA, USA.
Frequency-domain analysis of brain tissue motion has received increased focus in recent years as an approach to describing the response of the brain to impact or vibration sources in the built environment. While researchers in many experimental and numerical studies have sought to identify natural resonant frequencies of the brain, limited description of the associated vibration modes limits comparison of results between studies. We performed a modal analysis to extract the natural frequencies and associated mode shapes of a finite element model of the head.
View Article and Find Full Text PDFJ Biomech Eng
January 2025
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA.
A criterion characterizing the combined neurotoxicity of amyloid beta and tau oligomers is suggested. A mathematical model that makes it possible to calculate a value of this criterion during senile plaque and NFT formation is proposed. Computations show that for physiologically relevant parameter values, the value of the criterion increases approximately linearly as time increases.
View Article and Find Full Text PDFOphthalmic Plast Reconstr Surg
January 2025
Ophthalmic Surgeons and Consultants of Ohio, Eye Center of Columbus, Columbus, Ohio.
A 59-year-old female patient presented with a purple, fluid-filled lesion on her left upper eyelid that contained a solid component. Excisional biopsy revealed a diagnosis of mucinous adenocarcinoma. Extensive oncological workup was negative for a distant primary tumor or metastasis and confirmed a diagnosis of primary mucinous adenocarcinoma.
View Article and Find Full Text PDFIntroduction: As pharmacological strategies remain limited for relieving fatigue and associated cognitive symptoms, integrative modalities such as traditional Chinese medicine (TCM) could be explored as therapeutic strategies in cancer survivors. Here, we evaluate and report the efficacy and safety of a TCM concoction, modified Xiang Bei Yang Rong Tang (XBYRT), on quality of life (QOL), cancer-related fatigue (CRF), and cognitive symptoms, compared to placebo.
Methods: In a single-centered, randomized, double-blinded, placebo-controlled pilot trial conducted from 2019 to 2022, fatigued cancer survivors ≥21 years old were recruited to receive the XBYRT intervention or placebo (5% diluted) once daily for the duration of 8 weeks.
Nanoscale Horiz
January 2025
State Key Laboratory of Electroanalytical Chemistry, Research Center of Biomembranomics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
Correction for 'Single glucose molecule transport process revealed by force tracing and molecular dynamics simulations' by Yangang Pan , , 2018, , 517-524, https://doi.org/10.1039/C8NH00056E.
View Article and Find Full Text PDFLiver Int
February 2025
Department of Medicine, University of Illinois College of Medicine, Peoria, Illinois, USA.
CNS Neurosci Ther
January 2025
Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, USA.
Introduction: Mitochondrial dysfunction stands as a pivotal feature in neurodegenerative disorders, spurring the quest for targeted therapeutic interventions. This review examines Ubiquitin-Specific Protease 30 (USP30) as a master regulator of mitophagy with therapeutic promise in Alzheimer's disease (AD) and Parkinson's disease (PD). USP30's orchestration of mitophagy pathways, encompassing PINK1-dependent and PINK1-independent mechanisms, forms the crux of this exploration.
View Article and Find Full Text PDFProtein Sci
February 2025
Department of Cell Biology and Genetics, Texas A&M Health Science Center, Texas A&M University, Bryan, Texas, USA.
The Drosophila intrinsically disordered protein Ultrabithorax (Ubx) undergoes a series of phase transitions, beginning with noncovalent interactions between apparently randomly organized monomers, and evolving over time to form increasingly ordered coacervates. This assembly process ends when specific dityrosine covalent bonds lock the monomers in place, forming macroscale materials. Inspired by this hierarchical, multistep assembly process, we analyzed the impact of protein concentration, assembly time, and subphase composition on the early, noncovalent stages of Ubx assembly, which are extremely sensitive to their environment.
View Article and Find Full Text PDFJ Eur Acad Dermatol Venereol
January 2025
Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care.
View Article and Find Full Text PDFTrauma Violence Abuse
January 2025
Rollins School of Public Health, Emory University, Atlanta, GA, USA.
We present the first systematic review and meta-analysis of the literature on intimate partner violence (IPV) among LGBTQ+ adults in Latin America and the Caribbean (LAC). Of 1,234 articles, 22 met inclusion criteria, and data were extracted for 4 key research areas: prevalence, measurement, risk and protective factors, and interventions. LGBTQ+ adults in LAC experience IPV at similar or higher rates than those documented among cisgender heterosexuals, with estimates ranging from 0.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Department of Chemistry, Tennessee Tech University, Cookeville, Tennessee 38505, USA.
The first ground-state rotational spectrum of 3-methylstyrene (3MS) was measured by Fourier transform microwave spectroscopy under supersonic jet-cooled conditions. Transitions were assigned for two conformers: cis-3MS and trans-3MS. In the cis conformer, the vinyl group is oriented toward the methyl group, while in the trans conformer, it is positioned away from the methyl.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstraße 25, A-6020 Innsbruck, Austria.
Thiazole derivatives are biologically relevant molecules, used also in pharmaceutical applications. Herein, we report results for electron attachment to 2-bromo-5-nitrothiazole (BNT) in the gas phase. Employing two crossed electron-molecule beam experiments, we determined the efficiency curves of various fragment anions as a function of the initial electron energy between about 0 and 10 eV as well as the emission angle and kinetic energy distributions of Br- and NO2- ions formed from a resonance near 4 eV.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Ideal Vacuum Products, LLC, 5910 Midway Park Blvd. NE, Albuquerque, New Mexico 87109, USA.
The hydroxysilylene (HSiOH) molecule has been spectroscopically identified in the gas phase for the first time. This highly reactive species was produced in a twin electric discharge jet using separate precursor streams of 16O2/18O2 and Si2H6/Si2D6, both diluted in high pressure argon. The strongest and most stable laser induced fluorescence (LIF) signals were obtained by applying an electric discharge to each of the precursor streams and then merging the discharge products just prior to expansion into vacuum.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Department of Chemistry, Chicago Center for Theoretical Chemistry, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA.
Bottom-up coarse-grained (CG) modeling is an effective means of bypassing the limited spatiotemporal scales of conventional atomistic molecular dynamics while retaining essential information from the atomistic model. A central challenge in CG modeling is the trade-off between accuracy and efficiency, as the inclusion of often pivotal many-body interaction terms in the CG force-field renders simulation markedly slower than simple pairwise models. The Ultra Coarse-Graining (UCG) method incorporates many-body terms through discrete internal state variables that modulate the CG force-field according to, e.
View Article and Find Full Text PDFJ Chem Phys
January 2025
The University of Alabama, Department of Chemistry and Biochemistry, Shelby Hall, Tuscaloosa, Alabama 35487-0336, USA.
Potential energy curves (PECs) for the spin-free (ΛS) and spin-orbit (Ω) states associated with the four lowest-lying dissociation channels of Na2 and K2 were calculated at the SA-CASSCF/SO-CASPT2/aug-cc-pwCVQZ-DK level. The PECs of Na2 were consistent with the experimental data and with the FS-CCSD (2,0) calculations, reproducing the double-well and the "shelf" character for some of the potentials of the excited states. For K2, the PECs behaved in a similar way and the spectroscopic parameters for the ground and the excited states are in good agreement with the available experimental values.
View Article and Find Full Text PDFStat Med
February 2025
Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
With the increasing maturity of genetic profiling, an essential and routine task in cancer research is to model disease outcomes/phenotypes using genetic variables. Many methods have been successfully developed. However, oftentimes, empirical performance is unsatisfactory because of a "lack of information.
View Article and Find Full Text PDFClin Appl Thromb Hemost
January 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hematologic diseases are considered important contributors to cerebral venous sinus thrombosis (CVST) cases. This retrospective study aims to compare the difference of the clinical and radiological characters between CVST patients with and without hematologic diseases. Consecutive hospitalized CVST patients with hematologic disorders constituted the hematologic disorder group, while that without identifiable risk factors comprised the control group in this study.
View Article and Find Full Text PDFHealth Expect
February 2025
Department of Nursing, RMIT University, Melbourne, Australia.
Menopause, a significant life transition for half the global population, intersects biological, cultural and social dimensions. Despite its universal occurrence, menopause research has historically been dominated by biomedical perspectives, often neglecting women's voices and diverse experiences. This article highlights the importance of including women's perspectives in menopause research to ensure relevance, accuracy and equity.
View Article and Find Full Text PDFJ Feline Med Surg
January 2025
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Objectives: The objective of this study was to compare plasma glucagon-like peptide-2 (GLP-2) concentrations in cats with chronic enteropathies (CE) with those of healthy cats.
Methods: Nineteen client-owned cats with a histopathologic diagnosis of either idiopathic chronic enteropathy (CIE) or low-grade lymphoma and six healthy client-owned cats were enrolled in a prospective study between 2 December 2021 and 9 June 2023. Fasted and postprandial plasma GLP-2 concentrations were measured via ELISA in CE cats at the time gastrointestinal biopsies were obtained and before CE treatment.
J Vet Emerg Crit Care (San Antonio)
January 2025
Emergency and Critical Care Department, The Schwarzman Animal Medical Center, New York, New York, USA.
Objective: To assess the value of the abdominal fluid score (AFS) in cats following trauma in determining surgical needs, transfusion needs, and mortality.
Design: Multicenter retrospective observational study utilizing data from the Veterinary Committee on Trauma (VetCOT) registry.
Setting: VetCOT Veterinary Trauma Centers.
Compr Rev Food Sci Food Saf
January 2025
Department of Food Science and Technology, Virginia Tech, Blacksburg, Virginia, USA.
Gut microbiota and their metabolites profoundly impact host physiology. Targeted modulation of gut microbiota has been a long-term interest in the scientific community. Numerous studies have investigated the feasibility of utilizing dietary fibers (DFs) to modulate gut microbiota and promote the production of health-beneficial bacterial metabolites.
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