Epidemiology and Molecular Characterisation of Multidrug-Resistant Isolated from Cow Milk.

Antimicrobial resistance (AMR) is a growing global concern and poses a significant threat to public health. The emergence of multidrug-resistant organisms, including , also presents a risk of transmission to humans through the food chain, including milk. This study aimed to investigate the prevalence of in raw milk in the Chattogram metropolitan area (CMA) of Bangladesh and their phenotypic and genotypic antimicrobial resistance patterns.

Mutation in Linked to Altered O-Antigen Biosynthesis and Attenuated Virulence in Rough Infantis Variant.

serovar Infantis has emerged as a prevalent foodborne pathogen in poultry with significant global health implications. This study investigates the molecular characteristics influencing virulence in a Infantis rough variant collected from a poultry farm in the USA. In this study, whole genome sequencing and comparative genomics were performed on smooth and rough poultry Infantis isolates, while chicken embryo lethality assay was conducted to assess their virulence.

A Systematic Review on the Impact of Vaccination for Respiratory Disease on Antibody Titer Responses, Health, and Performance in Beef and Dairy Cattle.

Bovine respiratory disease (BRD) is a multifactorial disease complex commonly affecting beef and dairy operations. Vaccination against major BRD-related pathogens is routinely performed for disease prevention; however, uniform reporting of health and performance outcomes is infrequent. Our objective was to evaluate the effect of commercially available BRD-pathogen vaccination on titer response with respect to health or performance in beef and dairy cattle.

Systemic Granulomatosis in the Meagre : Fishing for a Plausible Etiology.

Meagre () is one of the fast-growing species considered for sustainable aquaculture development along the Mediterranean and Eastern Atlantic coasts. The emergence of Systemic Granulomatosis (SG), a disease marked by multiple granulomas in various tissues, poses a significant challenge in meagre aquaculture. In the current study, we investigate the association of spp.

Mutational Landscape of Proto-Oncogene Coding Sequence in 62 Canine Cutaneous and Subcutaneous Mast Cell Tumors.

Canine mast cell tumors (MCTs) are common skin neoplasms with varying biological behaviors. The proto-oncogene plays a key role in the development of these tumors, and internal tandem duplications on exon 11 are usually associated with more aggressive behavior, increased local recurrence, and decreased survival time. However, apart from exons 8-11 and 17, there is limited understanding of the overall mutational landscape in canine MCTs.

Deep Proteome Coverage of Microglia Using a Streamlined Data-Independent Acquisition-Based Proteomic Workflow: Method Consideration for a Phenotypically Diverse Cell Type.

As the primary innate immune cells of the brain, microglia play a key role in various homeostatic and disease-related processes. To carry out their numerous functions, microglia adopt a wide range of phenotypic states. The proteomic landscape represents a more accurate molecular representation of these phenotypes; however, microglia present unique challenges for proteomic analysis.

Management and outcomes among older adults with generalized epilepsy in routine clinical practice.

Generalized epilepsy is classically thought of as a disease of the young and adolescent, with rarely reported cases among older adults. We aimed to analyze management and outcomes in a population sparsely described in the literature through a retrospective single-center cohort design. After excluding individuals without follow-up, we identified 151 people ≥50 years at the time of electrographically confirmed generalized epilepsy.

Pediatric Neuroimaging of Multiple Sclerosis and Neuroinflammatory Diseases.

Using a pediatric-focused lens, this review article briefly summarizes the presentation of several demyelinating and neuroinflammatory diseases using conventional magnetic resonance imaging (MRI) sequences, such as T1-weighted with and without an exogenous gadolinium-based contrast agent, T2-weighted, and fluid-attenuated inversion recovery (FLAIR). These conventional sequences exploit the intrinsic properties of tissue to provide a distinct signal contrast that is useful for evaluating disease features and monitoring treatment responses in patients by characterizing lesion involvement in the central nervous system and tracking temporal features with blood-brain barrier disruption. Illustrative examples are presented for pediatric-onset multiple sclerosis and neuroinflammatory diseases.

BAE-ViT: An Efficient Multimodal Vision Transformer for Bone Age Estimation.

This research introduces BAE-ViT, a specialized vision transformer model developed for bone age estimation (BAE). This model is designed to efficiently merge image and sex data, a capability not present in traditional convolutional neural networks (CNNs). BAE-ViT employs a novel data fusion method to facilitate detailed interactions between visual and non-visual data by tokenizing non-visual information and concatenating all tokens (visual or non-visual) as the input to the model.

Pediatric Meningeal Diseases: What Radiologists Need to Know.

Evaluating altered mental status and suspected meningeal disorders in children often begins with imaging, typically before a lumbar puncture. The challenge is that meningeal enhancement is a common finding across a range of pathologies, making diagnosis complex. This review proposes a categorization of meningeal diseases based on their predominant imaging characteristics.

A Novel Method for the Generation of Realistic Lung Nodules Visualized Under X-Ray Imaging.

Objective: Image-guided diagnosis and treatment of lung lesions is an active area of research. With the growing number of solutions proposed, there is also a growing need to establish a standard for the evaluation of these solutions. Thus, realistic phantom and preclinical environments must be established.

Potential Importance of Maximal Upper Body Strength-Generating Qualities and Upper Body Strength Training for Performance of High-Intensity Running and Jumping Actions: A Scoping Review.

Purpose: To investigate the influence of upper body (UB) strength qualities and UB strength training on the performance of high-intensity running and jumping actions and to identify gaps and recommendations for future research.

Methods: A systematic search using the PRISMA Scoping Review protocol was conducted in February 2024 using PubMed, Scopus, and ICTRP. Studies eligible for inclusion were those that reported associations between UB or trunk maximal strength qualities (e.

Subregions of the Rotator Cuff Muscles Present Distinct Anatomy, Biomechanics, and Function.

Shoulder and elbow injuries are prevalent among baseball players, particularly pitchers, who experience repetitive eccentric loading of the shoulder, leading to muscle damage and increased injury risk. Nearly 40% of shoulder injuries in baseball occur in pitchers, with many facing low rates of return to sport. The rotator cuff (RC) muscles-supraspinatus (SSP), infraspinatus (ISP), subscapularis (SSC), and teres minor (TMin)-are crucial for shoulder stability, movement, and force generation, particularly in overhead sports.

Youth Soccer Heading Exposure and Its Effects on Clinical Outcome Measures.

Purposeful heading, in which players may use their heads to advance the ball in play, is a unique part of soccer. Clinical outcome measures used to aid in the diagnosis of a concussion have long been a cornerstone of the contemporary measurements associated with the short- and long-term effects of monitoring repetitive head impacts (RHI) and soccer heading exposure. The effects of RHI in the youth population are still unknown, therefore, the purpose of this study was to examine if heading exposure is predictive of changes in self-reported symptoms, neurocognitive functioning, gait, and balance in female youth soccer players over the course of one soccer season.

Relationship of Individual Athlete External Load, Session Rating of Perceived Exertion, and Athlete Playing Status Across a Collegiate Women's Basketball Season.

External (EL) and internal (IL) load are commonly used methods used to quantify training load in team sports. Playing time and playing position may influence the training loads for specific athletes throughout a season. The purpose of the current study was to evaluate the effect of athlete playing status and individual in-season practices on EL and IL across a collegiate women's basketball season.

Comparison of Vertical Jump Force-Time Metrics Between ACL-Injured and Healthy Semi-Professional Male and Female Soccer Players.

Given the increasing use of innovative force plate systems in applied sports settings and the impact that anterior cruciate ligament (ACL) injuries have on team success, the purpose of the present study was to compare the lower-body neuromuscular performance characteristics of athletes who underwent ACL reconstruction (ACLR) and their non-injured counterparts (i.e., healthy controls).

A Comparison of Three Protocols for Determining Barbell Bench Press Single Repetition Maximum, Barbell Kinetics, and Subsequent Measures of Muscular Performance in Resistance-Trained Adults.

Background: One repetition maximum (1RM) is a vital metric for exercise professionals, but various testing protocols exist, and their impacts on the resulting 1RM, barbell kinetics, and subsequent muscular performance testing are not well understood. This study aimed to compare two previously established protocols and a novel self-led method for determining bench press 1RM, 1RM barbell kinetics, and subsequent muscular performance measures.

Methods: Twenty-four resistance-trained males (n = 12, 24 ± 6.

Children's Individual Differences in the Responses to a New Method for Physical Education.

Children's fundamental movement skills (FMS) require planned and guided interventions to develop appropriately. We investigated the effect of a novel Physical Education (PE) method to develop children's object control, locomotor skills, and motor competence. Further, we examined children's trainability, i.

Quantification of Ground Reaction Forces During the Follow Through in Trained Male Cricket Fast Bowlers: A Laboratory-Based Study.

Ground reaction forces (GRFs) are known to be high during front foot contact of fast bowling deliveries in cricket. There is a lack of published data on the GRFs during follow through foot contacts. The aim of this study was to quantify and compare peak GRFs and impulse of the delivery stride and the follow through of fast bowling deliveries.

Education for Healthcare Providers: Impact of Academic Detailing on Reducing Misinformation and Strengthening Influenza Vaccine Recommendations.

Background: Recommendations from a trusted healthcare provider have been shown to be the most effective intervention for encouraging patients to be vaccinated. However, providers have reported feeling less prepared to address vaccination questions and having less time to discuss vaccines with patients than before the COVID-19 pandemic. Providers may benefit from a brief update about the available influenza vaccines and vaccination guidelines.

Objectively-Measured Sedentary Time and Self-Reported Prescription Medication Use Among Adults: A Pilot Study.

While previous research has linked physical activity (PA) with lower prescription medication consumption, limited evidence has investigated sedentary time (ST) as a major contributor to medication use, despite ST's known association with chronic disease and mortality risk, even when PA volume is considered. This study aimed to examine the independent associations between objectively measured ST, patterns of sedentary bouts, and self-reported prescription medication use among adults ≥25 years of age. Thirty-two participants reported the number and type of medications they were currently prescribed and wore an accelerometer continuously on their hip for seven days to detect their ST.

Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics.

Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic exposure for successful therapy. Proposed benefits of administration via continuous infusion include less IV manipulation, decreased potential for antibiotic resistance, and potential cost savings.

Insights from a National Survey on Controlled Substance Diversion Practices in U.S. Hospital Pharmacies: Opportunities for Enhanced Surveillance and Compliance.

This study explored controlled substance (CS) diversion surveillance practices within hospital pharmacies across the United States. A survey with questions based on published CS diversion risk points was conducted in May 2024. A total of 66 participants from 31 states responded, with 54.

Epidemiology of Lymphatic Filariasis Antigen and Microfilaria in Samoa, 2019: 7-9 Months Post Triple-Drug Mass Administration.

The elimination of lymphatic filariasis (LF) as a public health problem remains an ongoing challenge in the Pacific region. This study reports on antigen (Ag) and microfilaria (Mf) prevalence in Samoa in 2019, 7-9 months after the completion of the first round of triple-drug mass drug administration (MDA). It evaluates the effectiveness of the intervention for reducing Ag prevalence to below a 2% threshold, and how this differs between 5-9-year-olds and ≥10-year-olds.

Diagnosis and Management of Kaposi Sarcoma-Associated Herpesvirus Inflammatory Cytokine Syndrome in Resource-Constrained Settings: A Case Report and an Adapted Case Definition.

Kaposi sarcoma-associated herpes virus (KSHV), also known as human herpes virus 8 (HHV-8), is the primary etiologic cause of Kaposi sarcoma (KS) and KSHV Inflammatory Cytokine Syndrome (KICS). Patients with KICS demonstrate symptoms of systemic inflammation, high KSHV viral load, elevation of inflammatory markers, and increased mortality. Management requires rapid diagnosis, treatment of underlying HIV, direct treatment of KS, and addressing the hyperimmune response.