5,634,946 results match your criteria: "USA; Drexel University[Affiliation]"
BMJ Oncol
August 2024
Department of Surgery & Cancer, Hammersmith Hospital, London, UK.
Objectives: The UK's withdrawal from the European Union (a political movement known as 'Brexit') incited concern both in the public and private sector about the future of drug development and the clinical trial landscape in the UK. This study evaluates trends in the initiation of phase III clinical trials that evaluated systemic anticancer treatments from 2010 to 2022 both in the UK and worldwide.
Methods And Analysis: Relevant clinical trials were identified through ClinicalTrials.
BMJ Oncol
August 2024
Technology & Innovation Center, GE HealthCare, Niskayuna, NY, USA.
Objective: Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multiple apoptosis pathway proteins at single cell level and determine multi-protein associations with recurrence risk and chemotherapy response in patients with stage II colorectal cancer (CRC).
Methods And Analysis: Multiplexed imaging of 16 proteins in the intrinsic and extrinsic apoptosis pathways at single cell resolution on resected tissue from 194 patients with stage II CRC who either received adjuvant chemotherapy (n108) or were treated with surgery only (n=86).
BMJ Oncol
August 2024
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background: Immune checkpoint inhibitors (ICIs) can cause severe and sometimes long-standing immune-related adverse events (irAEs). Enhanced immune activation from ICI can theoretically result in osteoclast activation, bone loss and fracture. The objective of this study was to evaluate the incidence rates of major osteoporotic fractures (MOFs) in patients with melanoma treated with ICI.
View Article and Find Full Text PDFJ Diabetes Metab Disord
June 2025
Ossian Health Economics and Communications GmbH, Bäumleingasse 20, Basel, 4051 Switzerland.
Objectives: This analysis quantifies the potential long-term clinical and cost benefits of early and intensive metabolic control (EIMC) versus conventional management in patients newly diagnosed with type 2 diabetes in Italy.
Methods: The PRIME T2D Model was used to project clinical and cost outcomes over long-term time horizons for a newly diagnosed cohort of patients receiving EIMC or conventional management. EIMC was associated with a mean glycated hemoglobin reduction of 0.
Sleep Epidemiol
December 2024
Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Population-based evidence linking sleep characteristics with hearing is limited and how the associations change with age remains unknown. We aim to investigate cross-sectional associations between sleep characteristics and hearing by age in a nationally representative sample of U.S.
View Article and Find Full Text PDFVirus Evol
December 2024
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA.
HIV-1 Vif's principal function is to counter the antiretroviral activities of DNA-editing APOBEC3 cytidine deaminases. Unconstrained APOBEC3 activity introduces premature stop codons in HIV-1 genes and can lead to viral inactivation. To investigate the evolution and diversification of Vif over the HIV-1 pandemic and document evidence of APOBEC3-mediated pressure, we analyzed 4612 publicly available sequences derived from 10 dominant subtypes and circulating recombinant forms (CRFs) using the Hervé platform.
View Article and Find Full Text PDFDigit Health
January 2025
Global Remote Research Scholars Program, St Paul, MN, USA.
Introduction: Social media plays a significant role in fostering communities around health and wellness. The hashtag #PCOSweightloss has become a pivotal forum on the platform X, where individuals exchange experiences, share information, and motivate each other concerning weight loss strategies connected with Polycystic Ovary Syndrome (PCOS).
Objective: This study aims to analyze the trends of #PCOSweightloss on X to gain insights into the social media metrics, including overall hashtag reach, key themes, and potential influence on management practices of PCOS.
J Glob Infect Dis
December 2024
Department of Emergency Medicine, Emergency Medicine Residency Program, Sarasota Memorial Hospital, Florida State University College of Medicine, Sarasota, FL, USA.
J Glob Infect Dis
December 2024
Department of Internal Medicine, Division of Infectious Diseases, Loyola University Medical Center, Maywood, IL, USA.
Introduction: Antibiotic stewardship is a critical aspect of managing cancer patients with febrile neutropenia (FN) to limit the development of drug-resistant organisms and minimize adverse drug effects. Thus, it has been recommended that patients with FN receiving empiric antibiotics should be re-evaluated for safe antibiotic de-escalation.
Methods: Subjects treated with meropenem for febrile neutropenia who met Loyola University Medical Center's (LUMC) criteria for de-escalation were stratified based on whether meropenem was de-escalated, and 30-day all-cause mortality for both groups was assessed.
Prev Med Rep
February 2025
Sandra Rosenbaum School of Social Work, University of Wisconsin-Madison, 1350 University Avenue, Madison, WI 53706, USA.
Objective: To investigate 15-year changes in public awareness of the social determinants of health (SDoH) between 2007 and 2023.
Methods: A 2007 survey of 1172 Wisconsin, U.S.
Curr Dev Nutr
January 2025
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Micronutrient deficiencies, undernutrition, and overweight/obesity are prevalent in low- and middle-income countries (LMICs). Nutrient profiling models (NPMs), initially developed to help reduce the prevalence of diet-related chronic diseases in Western countries, could be one solution to promote nutrient-dense foods in LMICs. This study reviewed government-endorsed NPMs implemented in LMICs and assessed their key components in relation to country-specific nutritional challenges.
View Article and Find Full Text PDFBiochem Biophys Rep
March 2025
Department of Chemistry, University of Nebraska at Kearney, USA.
Human citrate synthase (hCS) was kinetically characterized through full progress curve kinetic modelling using kinetic simulation, global fitting of the direct AcCoA to CoA transition, and a coupled thiol probe reaction to better determine the kinetics with low substrate concentration. Our analysis provides one of the most rigorous kinetic analyses of any citrate synthase ruling out the need to invoke complex cooperative mechanisms to explain progress curve data. Furthermore, we collected and modeled stopped-flow pH-dependent kinetic data with CoA and popular thiol probes such as Ellman's reagent (DTNB) and 4,4'-Dithiodipyridine (DPS), providing the opportunity for detailed kinetic simulations using these thiol probes with CoA producing enzymes.
View Article and Find Full Text PDFSurg Open Sci
August 2024
University of California, Irvine, Department of Surgery, Division of Trauma, Burns and Surgical Critical Care, Orange, CA, USA.
Background: There is a paucity of literature guiding trauma surgeons in the care of patients with active metastatic cancer (MC). Even less is known regarding outcomes for MC patients requiring emergent surgery after trauma. We hypothesized that trauma patients with active Metastatic Cancer (MC) have an increased mortality rate and undergo increased rates of withdrawal of care (WoC) within 72-hours following emergent operations, compared to similarly matched patients without MC.
View Article and Find Full Text PDFIn patients with severe refractory immune thrombocytopenia (ITP), especially those unable to receive blood transfusions due to religious beliefs, alternative non-cytotoxic therapies are important to avoid worsening cytopenias. Immunomodulatory agents such as mycophenolate mofetil and daratumumab should be used alongside traditional therapies including steroids, IVIG and rituximab.
View Article and Find Full Text PDFAdv Orthop
January 2025
Division of Plastic Surgery, Lurie Children's Hospital of the Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
The present study analyzes the effects of preoperative serum albumin, hematocrit, and creatinine on postoperative outcomes in patients undergoing carpal tunnel decompression surgery. The American College of Surgeons National Quality Improvement Program (NSQIP) database was queried from 2011 to 2020. Albumin, hematocrit, and creatinine were collected for each patient, alongside covariates.
View Article and Find Full Text PDFAppl Magn Reson
October 2024
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520 USA.
Unlabelled: Temperature-dependent DEER effects are observed as a function of methyl rotation by either leucine- or nitroxide-specific protonated methyl groups in an otherwise deuterated background. Both species induce a site-specific enhancement in the apparent relaxation of the paramagnetic nitroxide label. The presence of a single protonated methyl group in close proximity (4-10 Å) to only one of the two nitroxide rotamer ensembles in AviTagged immunoglobulin-binding B domain of protein A results in a selective and substantial decrease in , manifested by differential decay of the peak intensities in the bimodal distance distribution as a function of the total dipolar evolution time, temperature, or both.
View Article and Find Full Text PDFAdv Med Educ Pract
January 2025
School of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Systematically generating differential diagnoses facilitates a clinician's history, physical exam, and clinical evaluation. is an acronym for pathophysiologies to consider in a differential diagnosis: immune reactions and dysregulation, metabolic, psychiatric, allergic, structural, social, infectious, vascular, endocrine/exocrine, degenerative, iatrogenic, congenital, traumatic, autoimmune, toxic, idiopathic, neoplastic, and genetic. We suggest that this mnemonic includes several improvements on previous pathophysiology-based acronyms and have informally validated this new mnemonic with two lists of common diseases.
View Article and Find Full Text PDFJ STEM Educ Res
January 2025
Institute for Health Disparities, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Given the differences in trajectory for under-represented minorities in biomedical careers, we sought to explore how a virtual mentoring program, the National Research Mentoring Network (NRMN), and its platform (MyNRMN), may facilitate transitions in the science, technology, engineering, mathematics, and medicine (STEMM) pipeline. The purpose of this study was to describe how the size of an MyNRMN member's mentoring network and level of engagement correlate with academic and career transitions. We examined MyNRMN platform user data from March 2020 to May 2021 ( = 2993).
View Article and Find Full Text PDFNeuroimage Rep
December 2024
The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, New York City, NY, USA.
Introduction: Alzheimer's disease (AD) is a phenotypically and pathologically heterogenous neurodegenerative disorder. This heterogeneity can be studied and disentangled using data-driven clustering techniques.
Methods: We implemented a self-organizing map clustering algorithm on baseline volumetric MRI measures from nine brain regions of interest (ROIs) to cluster 1041 individuals enrolled in the placebo arm of the EXPEDITION3 trial.
Kidney Cancer
February 2024
University of California San Diego, San Diego, CA, USA.
Liquid biopsy techniques have developed rapidly in recent years and demonstrated success in cancer detection, disease characterization, and ongoing disease monitoring. These components, including circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and cell-free DNA (cfDNA), offer minimally invasive diagnostic tools that provide valuable insights into the genomic landscape of tumors. Its applications have expanded to include various malignancies, including renal cell carcinoma (RCC).
View Article and Find Full Text PDFInterv Pain Med
March 2025
Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA.
Trauma Surg Acute Care Open
January 2025
Expeditionary and Trauma Medicine, Naval Medical Research Unit San Antonio, JBSA-Fort Sam Houston, Texas, USA.
Background: Non-compressible torso hemorrhage (NCTH) represents a leading cause of preventable mortality in trauma. Resuscitative endovascular balloon occlusion of the aorta (REBOA) stabilizes NCTH but may predispose patients to thrombus generation. REBOA must therefore be prospectively evaluated for coagulation risks with concomitant usage of anti-fibrinolytic tranexamic acid (TXA).
View Article and Find Full Text PDFAppl Psychol Meas
January 2025
Wright State University, Dayton, OH, USA.
This study compared maximum a posteriori (MAP), expected a posteriori (EAP), and Markov Chain Monte Carlo (MCMC) approaches to computing person scores from the Multi-Unidimensional Pairwise Preference Model. The MCMC approach used the No-U-Turn sampling (NUTS). Results suggested the EAP with fully crossed quadrature and the NUTS outperformed the others when there were fewer dimensions.
View Article and Find Full Text PDFResusc Plus
January 2025
Department of Pediatrics, University of Virginia School of Medicine, Box 800386, Charlottesville, VA 22908, USA.
Background: More than 90% of in-hospital cardiac arrests involving children occur in an intensive care unit (ICU) with less than half surviving to discharge. We sought to assess the association of the display of risk scores of cardiovascular and respiratory instability with the incidence of cardiac arrest in a pediatric ICU.
Methods: Employing supervised machine learning, we previously developed predictive models of cardiovascular and respiratory instability, incorporating real-time physiologic and laboratory data, to display risk scores for potentially catastrophic clinical events in the subsequent 12 h.
Access Microbiol
January 2025
Department of Biological Sciences, The George Washington University, Washington DC 20052, USA.
Comparing the diversity of gut microbiota between and within social insect colonies can illustrate interactions between bacterial community composition and host behaviour. In many eusocial insect species, different workers exhibit different task behaviours. Evidence of compositional differences between core microbiota in different worker types could suggest a microbial association with the division of labour among workers.
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