5,626,240 results match your criteria: "USA; Columbia University Irving Medical Center[Affiliation]"

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in "microenvironmental-ity".

Cancer Metastasis Rev

January 2025

Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.

Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upon injury and cancer onset, this review specifically focuses on how sympathetic nerves rewire the TME. Within tumors, sympathetic nerves closely interact with various TME components, and their combined signaling often shifts tumor-intrinsic physiology toward tumor-supportive phenotypes.

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Depression in High-Risk Offspring: The Mediating Role of Sleep Problems.

Res Child Adolesc Psychopathol

January 2025

Department of Psychology and Neuroscience, Temple University, 1701 N. 13th St, Philadelphia, PA, 19122, USA.

Parental depression is associated with offspring depression and sleep problems are prospectively associated with the development of depression. However, little work has examined sleep problems in the offspring of depressed parents and whether these problems partially account for the association between parent and offspring depression. This longitudinal study examined the indirect effect of sleep problems on the association between parent psychopathology and offspring depression in a sample of 10,953 10 to 12-year-old children participating in the Adolescent Brain and Cognitive Development (ABCD) study.

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Purpose Of Review: Artificial Intelligence (AI) technology will significantly alter critical care cardiology, from our understanding of diseases to the way in which we communicate with patients and colleagues. We summarize the potential applications of AI in the cardiac intensive care unit (CICU) by reviewing current evidence, future developments and possible challenges.

Recent Findings: Machine Learning (ML) methods have been leveraged to improve interpretation and discover novel uses for diagnostic tests such as the ECG and echocardiograms.

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Purpose: To describe the safety and assess the feasibility of using intracameral cefuroxime sodium (Aprokam®) during congenital cataract surgery as a preventive measure for endophthalmitis.

Design: Monocentric, prospective, observational pilot study.

Setting: San Giuseppe Hospital, University of Milan, Milan, Italy.

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Cytology's sunset: is it time to embrace new biomarkers for upper tract urothelial carcinoma?

Minerva Urol Nephrol

December 2024

European Association of Urology (EAU), Young Academic Urologists (YAU) Renal Cancer Working Group, Arnhem, the Netherlands.

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Background: Transperitoneal approach to robot-assisted pyeloplasty (RAP) have been preferred in the last decades because of the use of multi-port robotic platforms. However, this approach is linked to notable issues, such as pneumoperitoneum and lateral decubitus position, which is associated with potential soft tissues injuries, and it is a time-consuming procedure. Single-port (SP) platform was introduced to potentially address these issues.

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Single atom alloys aggregation in the presence of ligands.

Nanoscale

January 2025

Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Single atom alloys (SAAs) have gained tremendous attention as promising materials with unique physicochemical properties, particularly in catalysis. The stability of SAAs relies on the formation of a single active dopant on the surface of a metal host, quantified by the surface segregation and aggregation energy. Previous studies have investigated the surface segregation of non-ligated and ligated SAAs to reveal the driving forces underlying such phenomena.

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Effective team science requires procedural harmonization for rigor and reproducibility. Multicenter studies across experimental modalities (domains) can help accelerate translation. The Translational Outcomes Project in NeuroTrauma (TOP-NT) is a pre-clinical traumatic brain injury (TBI) consortium charged with establishing and validating noninvasive TBI assessment tools through team science.

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This study introduces a method for synthesizing electrically conductive hydrogels by incorporating a self-assembled, percolating graphene network. Our approach differs from previous approaches in two crucial aspects: using pristine graphene rather than graphene oxide and self-assembling the percolation network rather than creating random networks by blending. We use pristine graphene at an oil-water interface to stabilize a water-in-oil emulsion, successfully creating hydrogel foams with conductivities up to 15 mS m and tunable porosity.

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Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms.

Adv Healthc Mater

January 2025

Department of Biochemistry and Molecular and Cellular Biology, School of Medicine, Georgetown University, Washington, DC, 20057, USA.

Glucocorticoids (GCs) are standard-of-care treatments for inflammatory and immune disorders, and their long-term use increases the risk of osteoporosis. Although GCs decrease bone functionality, their role in bone microvasculature is incompletely understood. Herein, the study investigates the mechanisms of bone microvascular barrier function via osteoblast-endothelial interactions in response to GCs.

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Ionic Liquid Aided [C]CO Fixation for Synthesis of C-carbonyls.

ChemistryOpen

January 2025

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, CAMH, Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Tributyl(ethyl)phosphonium oxopentenolate ([P][Pen]) is an ionic liquid developed to capture CO and has shown ability to catalyze carbonylation reactions in organic chemistry. Carbon-11 (C, t=20.4 min) labeled CO is a highly versatile building block for the synthesis of positron emission tomography (PET) radiotracers that are applied for medical imaging.

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Extracellular vesicle-mediated VEGF-A mRNA delivery rescues ischaemic injury with low immunogenicity.

Eur Heart J

January 2025

School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 2199 Lishui Rd, Nanshan, Shenzhen, Guangdong Province 518055, China.

Background And Aims: Lackluster results from recently completed gene therapy clinical trials of VEGF-A delivered by viral vectors have heightened the need to develop alternative delivery strategies. This study aims to demonstrate the pre-clinical efficacy and safety of extracellular vesicles (EVs) loaded with VEGF-A mRNA for the treatment of ischaemic vascular disease.

Methods: After encapsulation of full-length VEGF-A mRNA into fibroblast-derived EVs via cellular nanoporation (CNP), collected VEGF-A EVs were delivered into mouse models of ischaemic injury.

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Breastfeeding Among First-Time Mothers Reporting Housing Insecurity and Food Insecurity.

J Womens Health (Larchmt)

January 2025

Division of General Internal Medicine, Department of Medicine, University of California at San Francisco, San Francisco, California, USA.

Despite health benefits to both infants and mothers, many are not breastfeeding as recommended by national guidelines. Prior studies examining the effects of housing insecurity and food insecurity on breastfeeding intention and duration have been limited and yielded mixed findings. To assess the relationship among housing insecurity, food insecurity, and breastfeeding, we conducted a secondary analysis of a cohort of nulliparous U.

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Pelvic running injuries often require extensive rehabilitation and pelvic girdle pain is a barrier to running engagement in population sub-groups, such as perinatal women. However, exploration into how external pelvic loading may be altered during running is limited. This study assessed which biomechanical variables influence changes in external peak pelvic acceleration during treadmill running, across various stride frequency conditions.

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Objective: To investigate whether local lesions created by stereo-electroencephalography (SEEG)-guided radiofrequency thermocoagulation (RFTC) affect distant brain connectivity and excitability in patients with focal, drug-resistant epilepsy (DRE).

Methods: Ten patients with focal DRE underwent SEEG implantation and subsequently 1 Hz bipolar repetitive electrical stimulation (RES) for 30 s before and after RFTC. Root mean square (RMS) of cortico-cortical evoked potentials (CCEPs) was calculated for 15 ms to 300 ms post-stimulation with baseline correction.

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Cannabis and Breastfeeding.

Breastfeed Med

January 2025

Division of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, California, USA.

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This study used a natural experiment design to examine the impact of ethnic studies courses on students' ethnic-racial identity (ERI) development, multicultural attitudes, and civic engagement during the 2021-2022 school year in Minneapolis, MN (N = 535; 33.5% White, 29.5% Black, 21.

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Enhanced dielectric losses in α-MnO protonation modulation.

Chem Commun (Camb)

January 2025

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing 210044, China.

MnO octahedra without distortions in α-MnO have a low dipole content, which limits their dielectric loss capabilities. Herein, we develop protonated MnO with distorted MnO octahedra for increased dipole numbers a two-step hydrothermal method. In comparison with α-MnO, this protonated MnO provides greatly improved dipole polarization loss capabilities, resulting in a reflection loss value of -19.

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Near-infrared (NIR) chemiluminescent probes have attracted increasing attention in recent years due to their attractive properties for imaging. Herein, we developed a NIR chemiluminophore silicon rhodamine (SiRCL-1) based on the intramolecular energy transfer process from excited state benzoate to a silicon rhodamine emitter under aqueous conditions. SiRCL-1 exhibited dual emission peaks at 540 nm and 680 nm with a high signal penetration through tissue at 680 nm (>30 mm) and long-lasting luminescence (>50 min), demonstrating its significance as a chemiluminescence scaffold for biological application.

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Background: Platelet activation plays a central role in the pathogenesis of acute coronary syndrome (ACS). Platelet morphological parameters, including MPV, PDW, and P-LCR, are emerging as biomarkers for predicting the severity of ACS and prognosis.

Aims: This study aims to assess the relationship between these parameters and coronary severity and to evaluate their predicting adverse outcomes.

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A female sterilization method for use in field-based behavioral studies of the invasive Asian longhorned beetle (Anoplophora glabripennis).

J Insect Sci

January 2025

Northern Research Station, U.S. Forest Service, United States Department of Agriculture, Hamden, CT, USA.

Asian longhorned beetle (Anoplophora glabripennis Motschulsky), a wood borer (Coleoptera: Cerambycidae) native to China, has been unintentionally and repeatedly introduced to North American and European landscapes as a stow-away in the wood packing material commonly used in international trade. Asian longhorned beetle causes extensive damage and mortality in multiple deciduous tree species and in response, countries in both North America and Europe have adopted policies of eradication. Models that integrate patterns of Asian longhorned beetle dispersal with records of infested trees are critical in optimizing survey and eradication efforts and tracking eradication progress.

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Utilizing preterm infant body composition assessments to guide neonatal nutrition.

Curr Opin Pediatr

January 2025

Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.

Purpose Of Review: The use of body composition to assess the quality of infant growth may add valuable information to pediatric clinical care. Preterm infants have differences in their fat and muscle mass development compared with infants born at term, which may be related to their early nutritional exposures. This review focuses on recent studies examining early nutrition in preterm infants and related body composition outcomes in the newborn period and beyond.

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