Variants in Parathyroid Carcinoma and Atypical Parathyroid Tumors.

Parathyroid carcinoma (PC) and atypical parathyroid tumors (APT) are incompletely understood and pose challenges in definitive diagnosis. sequence variants have recently been linked to PC and APT. Inactivating mutations in the ubiquitously expressed tumor suppressor gene, encoding folliculin, cause Birt-Hogg-Dubé syndrome (BHD), a rare tumor predisposition syndrome.

Thirty years from FDA approval of pegylated liposomal doxorubicin (Doxil/Caelyx): an updated analysis and future perspective.

In 2025, it will be 30 years since the initial clinical approval of pegylated liposomal doxorubicin (PLD) by the Food and Drug Administration. PLD predated the field of nanomedicine and became a model nanomedicine setting key pharmacological principles (prolonged circulation, slow drug release and the enhanced permeability and retention (EPR) effect) for clinical application of other nano-drugs in cancer therapy. The impressive reduction of cardiotoxicity conferred by PLD is the most valuable clinical asset.

Molecular and immune landscape of tumours in geriatric patients with non-small cell lung cancer, melanoma and renal cell carcinoma.

Objective: Cancer patients aged ≥80 years present unique characteristics affecting response to immune checkpoint inhibitors (ICIs), with unidentified molecular differences. This study aimed to explore potential biomarkers of response to ICI in patients ≥80 years.

Methods And Analysis: We analysed tumour samples (n=24 123) from patients ≥80 (versus<80) with non-small cell lung cancer (NSCLC), melanoma (MEL), and renal cell cancer (RCC).

In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate.

Unlabelled: Some double-blind, placebo-controlled trials have shown that Azelastine (Aze) high dose (0.15%) was effective in seasonal (SAR) and perennial allergic rhinitis (PAR). However, there was no long-term comparison between Aze 0.

Transcatheter Management of Tricuspid Regurgitation: A Review of Contemporary Evidence.

Tricuspid regurgitation (TR) is a common valvular heart disease that is associated with increased morbidity and mortality. Traditional surgical interventions, though definitive, carry considerable complexities and risks, especially for high-risk patients, with in-hospital mortality rates of ˜9%. This resulted in the undertreatment of many patients with TR, creating a substantial unmet need.

Advancements in Leadless Pacemakers: What the Second-generation Micra AV2 Brings to Cardiac Care.

Leadless pacemakers are considered one of the major technological advancements in cardiology in recent years. Many efforts are made to provide physiological atrio-ventricular (AV) pacing. With the first-generation leadless ventricular, dual, dual (VDD) pacemaker, Micra AV (Medtronic, Inc.

Vulnerable self-disclosure co-develops in adolescent friendships: Developmental foundations of emotional intimacy.

This study examines the development of vulnerable self-disclosure in supportive interactions from ages 13 to 29. A diverse community sample (N = 184; 85 boys 99 girls; 58% white, 29% Black, 13% other identity groups) participated in annual observed interactions with close friends and romantic partners. Participants were observed as they sought and provided support to their best friends each year from age 13 to 18, and as they sought support from their romantic partners from age 19 to 29.

Trait Social Anxiety Moderates the Relationship Between Emotion-Regulation Strategy Switching and State Anxiety in Daily Life.

Difficulty knowing when to switch emotion regulation (ER) strategies is theorized to be a key pathway to emotion dysregulation, but relatively few studies have empirically examined this. We applied a new order-based metric to quantify how =109 socially anxious people switched between 19 different ER strategies (or chose not to regulate at all) throughout a 5-week ecological momentary assessment study yielding 12,616 observations. We tested whether state and trait anxiety reports, and their interaction, predicted differences in ER strategy switching.

Mpox Virus as a Global Public Health Emergency: A Scoping Review.

The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. The virus that was endemic in West and Central Africa has now been reported with chains of global transmission to several countries. A scoping review was carried out from the relevant literature available from PubMed, Scopus and Web of Science.

Insights into the electronic, magnetic structure, and photocatalytic activity of YCuMnO double perovskite.

This research aims to develop YCuMnO double perovskite, using a citrate auto combustion method, to be used as a photocatalyst for the degradation of organic dyes and antibiotics. XRD and Raman characterization revealed the synthesis of pure-phase YCuMnO double perovskite. The X-ray photoelectron spectroscopy results show the presence of +4 and +2 oxidation states of Mn and Cu ions.

Insights into the specific capacitance of CNT-based supercapacitor electrodes using artificial intelligence.

In this study, the specific capacitance characteristics of a carbon nanotube (CNT) supercapacitor was predicted using different machine learning algorithms, such as artificial neural network (ANN), random forest regression (RFR), -nearest neighbors regression (KNN), and decision tree regression (DTR), based on experimental studies. The results of the simulation verified the accuracy of the ANN algorithm with respect to the data derived from the specific capacitance of the supercapacitor module. It was observed that there was a strong correlation between the experimental results and the predictions made by the ANN algorithm.

Ongoing invasions by American bullfrogs and red-eared sliders in the Republic of Korea.

Invasive species can be unpredictable in their ability to adapt and spread across novel landscapes. American bullfrogs () and red-eared sliders () have become invasive in South Korea since their introduction in the 1970s through the food and pet trades. One of the first steps to their population regulations is to determine each species' distribution in the country, which will allow for the identification of at-risk areas.

Impact of the COVID-19 pandemic on small vulnerable newborns: an interrupted time series analysis in Peru and Brazil.

Background: We examined COVID-19's impact on the number of small vulnerable newborns (SVN) at national and regional levels in Peru and Brazil.

Methods: Using national birth registries, we examined monthly numbers of preterm (PT), low birthweight (LBW), and small for gestational age (SGA) newborns. We analysed COVID-19's impact on SVN using two interrupted time series models.

Temporal trends of liver cancer burden, comparative analysis of risk factors and trend forecasts to 2024 in China, USA, the Republic of Korea, and Mongolia: an analysis based on multiple data sources from Global Burden of Disease 2019, the Global Cancer Observatory, and Cancer Incidence in Five Continents.

Background: Liver cancer represents a significant burden of disease globally, with variations in liver cancer status among countries. In this study, we aimed to evaluate the epidemiological burden of liver cancer in four representative countries - China, the USA, the Republic of Korea, and Mongolia - and cover the highest number of incidence cases, the highest prevalence rates and the burden in developed countries. In addition, we intended to predict the trends in liver cancer in these countries over the next six years.

Fistula in Crohn's disease: classification, pathogenesis, and treatment options.

Crohn's disease is a form of inflammation that affects the gastrointestinal (GI) tract. It is characterized by persistent inflammation in the gut, which can lead to the formation of abnormal connections called fistulas. These fistulas can occur between the GI tract and the abdominal cavity, adjacent organs, or the skin.

Cost-effectiveness of continuous real-time intracardiac recurrent event detection and alerting in high-risk acute coronary syndrome patients.

Background: ALERTS was a pivotal randomized clinical trial (RCT) evaluating an intracardiac monitor with real-time alerting in high-risk acute coronary syndrome patients. The cost-effectiveness however is unknown.

Method: A decision model estimated health effects and costs of implanting a Guardian device in a target patient population, compared to current standard-of-care (SOC).

A perylene-based fluorescent probe for highly efficient SDS detection.

Sodium dodecyl sulfate (SDS) is widely used in numerous household products and pharmaceuticals due to its excellent water solubility, emulsification, foaming, and dispersing properties. However, the extensive use of SDS has made it a significant environmental pollutant, posing a great threat to aquatic ecosystems. Therefore, developing a rapid, efficient, and sensitive probe for detecting SDS in aqueous environments is crucial.

Ionic gradients in flow to control transport of emissive ions.

Concentration gradients of simple salts in microfluidic channels control the transport of a common photoredox catalyst.

Prevalence and Correlates of Sexual Choking and Consensual Non-Consent (CNC) Among College Students: Findings from a Campus-Representative Survey.

Rough sex has become prevalent among young adults, yet little is known about the prevalence of consensual non-consent (CNC)-which is often enacted as role-playing sexual assault-or the correlates of either sexual choking or CNC. In a U.S.

Weighting methods for truncation by death in cluster-randomized trials.

Patient-centered outcomes, such as quality of life and length of hospital stay, are the focus in a wide array of clinical studies. However, participants in randomized trials for elderly or critically and severely ill patient populations may have truncated or undefined non-mortality outcomes if they do not survive through the measurement time point. To address truncation by death, the survivor average causal effect has been proposed as a causally interpretable subgroup treatment effect defined under the principal stratification framework.

Investigating novel pharmacological strategies for treatment-resistant depression: focus on new mechanisms and approaches.

Introduction: A substantial number of patients exhibit treatment-resistant depression (TRD), posing significant challenges to clinicians. The discovery of novel molecules or mechanisms that may underlie TRD pathogenesis and antidepressant actions are highly needed.

Areas Covered: Using the PubMed database, the authors searched for emerging evidence of novel approaches for TRD based on experimental and human studies.

Outcomes of Atrioventricular Septal Defect Repair: Two-Institutions, 10-Year Experience in Cordoba, Argentina.

Background: Outcomes following surgical repair of atrioventricular septal defect have improved over the last decades. Global mortality for repair of this defect is approximately 3.5%.

Impacts of a multipronged initiative with community HIV clinics to support retention and re-engagement in HIV care.

Background: Despite advances in HIV treatment, gaps in care retention threaten the individual health of people with HIV (people) and public health efforts to end the HIV epidemic.

Objective: This project aimed to identify and address gaps in retention and support re-engagement in care.

Methods: A multipronged initiative at five community HIV clinics and community-based organizations (CBOs) included patient, healthcare professional (HCP), and community-focused interventions.