True cancer stem cells exhibit relative degrees of dormancy and genomic stability.

Background: Cancer stem cells in human tumors have been defined by stem cell markers, embryonal signaling pathways and characteristic biology, ie., namely the ability to repopulate the proliferating population. However, even if these properties can be demonstrated within a tumor cell subpopulation, it does not mean that they are truly hierarchical stem cells because they could have been derived from the proliferating population in a reversible manner.

Comparative outcomes of endovascular vs. surgical treatment in craniocervical junction dural arteriovenous fistulas: A systematic review and meta-analysis.

Background: Craniocervical junction dural arteriovenous fistulas (CCJ-DAVFs) are rare and complex vascular malformations that are challenging to diagnose and treat. This study aims to compare surgical and endovascular treatments for CCJ-DAVFs through a systematic review and meta-analysis.

Methods: A systematic review and meta-analysis was conducted according to the PRISMA guidelines.

Conquering acceptability: A study of stakeholder inclusion practices in evaluation processes in francophone West African Countries.

Evaluation practices in the French-speaking countries of the West African Economic and Monetary Union (WAEMU) are poorly understood and infrequently documented. Our study is a descriptive analysis that elucidates how stakeholders are conceptualized and involved in evaluation processes in WAEMU. In these countries, evaluators are concerned about the weak stakeholder involvement in evaluation activity and call for greater stakeholder engagement, juxtaposed to the challenges of doing so.

Psyllium: A Nutraceutical and Functional Ingredient in Foods.

Psyllium is an excellent natural source of soluble and insoluble dietary fiber. It has been used as a nutraceutical and functional ingredient in foods. Many efforts have been made to understand and improve its physicochemical, biological, and functional properties to promote its food applications.

How Health Systems World-wide Fail Type 2 Diabetics.

For over 50 years, health systems the world over have failed people with type 2 diabetes mellitus (T2DM). The WHO documents a quadrupling of people with diabetes in a 34-year period to 422 million in 2014, the overwhelming majority of whom were T2DM. This happened despite extensive scientific literature on the causes of, as well as proven treatments for, this disease.

Medical Care or Deportation: Examining Interior Border Checkpoints and Access to Higher-Level Medical Care for Undocumented Immigrants in South Texas.

We examined the impacts of interior border checkpoints on access to higher-level medical care via ground ambulance for undocumented immigrants in South Texas. Using purposive sampling, we conducted interviews (n = 30) with ground ambulance personnel in the lower Rio Grande Valley, Texas. Procedures implemented in 2018 mandate that hospitals notify Border Patrol of a patient's legal status before transfer.

Capillary Electrophoresis-Mass Spectrometry for Top-Down Proteomics.

Mass spectrometry (MS)-based top-down proteomics (TDP) characterizes proteoforms in cells, tissues, and biological fluids (e.g., human plasma) to better our understanding of protein function and to discover new protein biomarkers for disease diagnosis and therapeutic development.

Informing ICU Digital Twins: Dynamic Assessment of Cardiorespiratory Failure Trajectories in Patients with Sepsis.

Understanding clinical trajectories of sepsis patients is crucial for prognostication, resource planning, and to inform digital twin models of critical illness. This study aims to identify common clinical trajectories based on dynamic assessment of cardiorespiratory support using a validated electronic health record data that covers retrospective cohort of 19,177 patients with sepsis admitted to ICUs of Mayo Clinic Hospitals over eight-year period. Patient trajectories were modeled from ICU admission up to 14 days using an unsupervised machine learning two-stage clustering method based on cardiorespiratory support in ICU and hospital discharge status.

Dysregulated Clot Mechanics and Kinetics Impacted by Injury Severity, Predict Mortality After Trauma.

Introduction: Coagulopathy following traumatic injury impairs stable blood clot formation and exacerbates mortality from hemorrhage. Understanding how these alterations impact blood clot stability is critical to improving resuscitation. Furthermore, the incorporation of machine learning algorithms to assess clinical markers, coagulation assays and biochemical assays allows us to define the contributions of these factors to mortality.

Assessing therapist skills in teletherapy: the development and validation of the tele-facilitative interpersonal skills task.

Teletherapy via videoconferencing has become common practice but has unique challenges. We aimed to develop and validate the first performance-based observer-rated measure of teletherapy skills: The Teletherapy Facilitative Interpersonal Skills Performance Task (Tele-FIS). We developed a set of 12 Tele-FIS video stimulus clips as simulations of four research-informed common therapeutic challenges in teletherapy: technology, distraction, boundaries and privacy, and emotional disconnection.

Informing Planetary Protection Policies for the Future Exploration of Ceres: State of Understanding after the Dawn Mission.

We review the current state of understanding of Ceres as it relates to planetary protection policy for future landed missions, including for sample return, to the dwarf planet. The Dawn mission found Ceres to be an intriguing target for a mission, with evidence for the presence of regional, possibly extensive liquid at depth, and local expressions of recent and potentially ongoing activity. The Dawn mission also found a high abundance of carbon in the regolith, interpreted as a mix of carbonates and amorphous carbon, as well as locally high concentrations of organic matter.

Production of Organic Precursors via Meteoritic Impacts and Its Implications for Prebiotic Inventory of Early Planetary Surfaces.

Meteoritic impacts on planetary surfaces deliver a significant amount of energy that can produce prebiotic organic compounds such as cyanides, which may be a key step to the formation of biomolecules. To study the chemical processes of impact-induced organic synthesis, we simulated the physicochemical processes of hypervelocity impacts (HVI) in experiments with both high-speed C projectiles and laser ablation. In the first approach, a C beam was accelerated to collide with ammonium nitrate (NHNO) to reproduce the shock process and plume generation of meteoritic impacts on nitrogen-rich planetary surfaces.

Waste Heat and Habitability: Constraints from Technological Energy Consumption.

Waste heat production represents an inevitable consequence of energy conversion as per the laws of thermodynamics. Based on this fact, by using simple theoretical models, we analyze constraints on the habitability of Earth-like terrestrial planets hosting putative technological species and technospheres characterized by persistent exponential growth of energy consumption and waste heat generation. In particular, we quantify the deleterious effects of rising surface temperature on biospheric processes and the eventual loss of liquid water.

On-farm evaluation of swede midge (Diptera: Cecidomyiidae) susceptibility among popular kale varieties.

The swede midge, Contarinia nasturtii Kieffer (Diptera:Cecidomyiidae), is a gall-forming insect pest that targets cruciferous plants. Since its introduction to North America in the early 2000s, the midge has expanded its range to include farming regions in Quebec and the Northeastern USA. In this study, we evaluated the susceptibility of 4 popular kale varieties-Green Curly-(Vates), Red Russian, Red Curly (RedBor), and Lacinato/Tuscan-to swede midge infestation in on-farm trials conducted over consecutive years.

Pathways from violence exposure to medication non-adherence: exploration of mental health symptoms and coping in people living with HIV in the U.S. South.

In the current study, we examine associations between exposure to violence and antiretroviral medication adherence in persons with HIV (PWH) in a southern city in the United States. We include investigation of a variety of violence exposures including childhood sexual abuse, physical abuse, witnessing family violence, lifetime violence exposures and current stress related to violence experiences, as well as neighborhood violence exposure. We examined associations between violence exposures and adherence and mediational pathways between these variables including mental health symptoms - specifically depressive, anxiety, and posttraumatic stress symptoms - as well as coping strategies.

Adaptations in surprising places.

Testosterone is controlled while it circulates in the bloodstream.

Mechanically robust and stretchable organic solar cells plasticized by small-molecule acceptors.

Emerging wearable devices would benefit from integrating ductile photovoltaic light-harvesting power sources. In this work, we report a small-molecule acceptor (SMA), also known as a non-fullerene acceptor (NFA), designed for stretchable organic solar cell (-OSC) blends with large mechanical compliance and performance. Blends of the organosilane-functionalized SMA BTP-Si4 with the polymer donor PNTB6-Cl achieved a power conversion efficiency (PCE) of >16% and ultimate strain (ε) of >95%.

In search of the female form Basic Books, 2025. 480 pp.

Bodies have long resisted easy categorization.

Antarctic krill vertical migrations modulate seasonal carbon export.

Vertical migrations by marine organisms contribute to carbon export by consumption of surface phytoplankton followed by defecation in the deep ocean. However, biogeochemical models lack observational data, leading to oversimplified representation of carbon cycling by migrating organisms, such as Antarctic krill (). Using a numerical model informed by 1 year of acoustic observations in the East Antarctic, we estimated the total particulate organic carbon (POC) flux from krill fecal pellets to be 9.

Variable impacts of land-based climate mitigation on habitat area for vertebrate diversity.

Pathways to achieving net zero carbon emissions commonly involve deploying reforestation, afforestation, and bioenergy crops across millions of hectares of land. It is often assumed that by helping to mitigate climate change, these strategies indirectly benefit biodiversity. Here, we modeled the climate and habitat requirements of 14,234 vertebrate species and show that the impact of these strategies on species' habitat area tends not to arise through climate mitigation, but rather through habitat conversion.

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 () deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes.

Behaviorally designed training leads to more diverse hiring.

A field experiment provides a promising proof of concept.