Assessing the Impact of Lymphedema Therapy Referral on Breast Cancer Survivors' Lymphedema Knowledge: A Cross-Sectional Survey.

Background: Lymphedema is a common problem that adversely impacts quality of life in breast cancer survivors. Although lymphedema risk is modifiable through behavior change, there is no standardized approach to educate survivors about risk-lowering strategies. Furthermore, misconceptions about lymphedema risk factors and risk-lowering strategies are common.

"I feel like my job is to give patients hope" - perspectives of Community Health Workers and employers in Iowa: a mixed methods study.

Introduction: Community Health Workers (CHWs) play a crucial role in extending health services, particularly for people who are medically underserved. Despite efforts to expand CHW programs nationally and in Iowa, challenges persist in defining their roles and responsibilities. Few studies have considered the perspectives of both CHWs and CHW employers simultaneously.

Determinants of vector-borne avian pathogen occurrence in a mosaic of habitat fragmentation in California.

Background: As habitat fragmentation increases, ecological processes, including patterns of vector-borne pathogen prevalence, will likely be disrupted, but ongoing investigations are necessary to examine this relationship. Here, we report the differences in the prevalence of Lyme disease (Borrelia burgdorferi sensu lato, s.l.

Next-generation sequencing-based population genetics unravels the evolutionary history of Rhodomyrtus tomentosa in China.

Background: Rhodomyrtus tomentosa (Ait.) Hassk. is useful for its ornamental, medicinal, and ecological characteristics, and is considered a "Neglected and Underutilized Crop Species".

Examining the cost burden of dietary supplements in older adults: an analysis from the AAA longroad study.

Background: The use of dietary supplements (DS) has steadily increased over the last several decades, particularly among older adults, contributing to the growth of the multibillion-dollar DS industry. The cost of prescription medication is a known contributor to medication nonadherence, yet the cost burden of DS among older adults is not well understood.

Methods: Using medication data from the 5-year multicenter longitudinal cohort AAA LongROAD study of older adults who drive, DS were identified and categorized.

Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity.

Organophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits. While acute treatment may alleviate immediate symptoms, the long-term consequences, particularly those involving neuroinflammation and systemic toxicity, remain poorly understood. This study used adult male and female Sprague Dawley rats to investigate the chronic effects of a single acute exposure to soman (132 µg/kg, s.

Localized Excision of Gastrointestinal Stromal Tumor (GIST) After Sleeve Gastrectomy: Highlighting a Sleeve-Preserving Surgical Approach.

Background: Gastrointestinal stromal tumors (GISTs) are relatively rare, accounting for approximately 0.1-3% of all gastrointestinal tumors. Their incidence is higher in individuals aged 50 to 70 years, with an equal gender distribution.

RT-QuIC detection of chronic wasting disease prions in third eyelids from white-tailed deer.

Chronic wasting disease (CWD) is a fatal neurodegenerative disease in cervids which is caused by prions, and new cases continue to appear in populations in North America and globally. The United States Department of Agriculture-approved tests for diagnosing CWD use obex and/or retropharyngeal lymph nodes, which are challenging to collect as the tissues require anatomical knowledge, skill, and time to dissect. Third eyelids contain lymphoid follicles and are easier to collect.

Slippery liquid infused porous surface (SLIPS) condensers for high efficiency air gap membrane distillation.

To address growing water scarcity, we must improve the energy efficiency of thermal desalination technologies such as air gap membrane distillation. However, promising functional materials such as slippery liquid infused porous surfaces have not yet implemented for any desalination technology. Here, we fabricate and test slippery liquid infused porous surfaces (using Krytox 16,256 lubricant and CuO nanostructures) in an air gap membrane distillation apparatus.

Forb diversity globally is harmed by nutrient enrichment but can be rescued by large mammalian herbivory.

Forbs ("wildflowers") are important contributors to grassland biodiversity but are vulnerable to environmental changes. In a factorial experiment at 94 sites on 6 continents, we test the global generality of several broad predictions: (1) Forb cover and richness decline under nutrient enrichment, particularly nitrogen enrichment. (2) Forb cover and richness increase under herbivory by large mammals.

Insulin resistance and cancer: molecular links and clinical perspectives.

The association between insulin resistance (IR), type 2 diabetes mellitus (T2DM), and cancer is increasingly recognized and poses an escalating global health challenge, as the incidence of these conditions continues to rise. Studies indicate that individuals with T2DM have a 10-20% increased risk of developing various solid tumors, including colorectal, breast, pancreatic, and liver cancers. The relative risk (RR) varies depending on cancer type, with pancreatic and liver cancers showing a particularly strong association (RR 2.

A comparison of art engagement in museums and through digital media.

As cultural consumption increasingly moves to a digital space, it is crucial to understand the evolving landscape of art consumption both in and outside of a physical museum context. The current study delves into this contrast, seeking to understand how art is perceived and appreciated in museums and on a digital medium (like a computer screen). Across two experiments at the Barnes Foundation and Penn Museum in Philadelphia, Pennsylvania, we explored how the aesthetic engagement of paintings and artifacts is influenced by the physical context in which an artwork is encountered and by the characteristics of the viewer.

Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome.

Mutations or deletions in the SHANK3 gene have been identified in up to 1% of autism spectrum disorder cases and are considered the primary cause of neuropsychiatric symptoms in Phelan McDermid syndrome (PMS). While synaptic dysfunctions have been extensively documented in the absence of Shank3, other mechanisms through which Shank3 may regulate neuronal functions remain unclear. In this study, we report that the ribosomal protein Rpl3 and overall protein synthesis are downregulated in the cortex and striatum of Shank3 knockout (KO) mice and in neurons differentiated from human-induced pluripotent stem cells (hiPSCs) derived from a PMS patient.

On the calculation of carbon and nutrient transport to the oceans.

Correct estimations of sediment, carbon, and nutrient fluxes are crucial for understanding the impacts of land use, environmental change, and climate change. However, limited measurements-often restricted to surface data or aliased data, i.e.

Debunking COVID-19 vaccine misinformation with an audio drama in Ghana, a randomized control trial.

Misinformation about COVID-19 vaccines has hampered their uptake worldwide. In Ghana, a belief that COVID-19 vaccines affect fertility is prevalent and difficult to counter. UNICEF Ghana co-produced a context-driven, behavioral science-based audio drama ('A shot of love') that aimed to debunk this misinformation narrative.

The membrane-proximal external region of human immunodeficiency virus (HIV-1) envelope glycoprotein trimers in A18-lipid nanodiscs.

During human immunodeficiency virus (HIV-1) entry, the metastable pretriggered envelope glycoprotein (Env) trimer ((gp120/gp41)) opens asymmetrically. We present cryo-EM structures of cleaved asymmetric Env trimers in amphipol-lipid nanodiscs. The gp41 membrane-proximal external region (MPER) could be traced in Env protomers that remained close to the nanodisc despite Env tilting.

Considerations for tactile perceptual assessments: impact of arm dominance, nerve, location, and sex in young and older adults.

Purpose: Intact tactile perception is essential to successfully interact with objects. While tactile examinations exist for capturing tactile impairments, recent investigations underscore that these examinations remain insufficient, particularly for adults following a neurological injury. To inform the design of improved tactile assessments, this study comprehensively captures factors that can influence tactile perception in young and older adults who are neurologically intact.

Pain classification using functional near infrared spectroscopy and assessment of virtual reality effects in cancer pain management.

Objective measurements of pain and safe methods to alleviate it could revolutionize medicine. This study used functional near-infrared spectroscopy (fNIRS) and virtual reality (VR) to improve pain assessment and explore non-pharmacological pain relief in cancer patients. Using resting-state fNIRS (rs-fNIRS) data and multinomial logistic regression (MLR), we identified brain-based pain biomarkers and classified pain severity in cancer patients.

Investigation of dynamic regulation of TFEB nuclear shuttling by microfluidics and quantitative modelling.

Transcription Factor EB (TFEB) controls lysosomal biogenesis and autophagy in response to nutritional status and other stress factors. Although its regulation by nuclear translocation is known to involve a complex network of well-studied regulatory processes, the precise contribution of each of these mechanisms is unclear. Using microfluidics technology and real-time imaging coupled with mathematical modelling, we explored the dynamic regulation of TFEB under different conditions.

Insensible water loss in extremely preterm infants cared for in incubators with 70% and 90% relative humidity.

Objective: To determine the insensible water losses (IWL) in preterm infants cared for in incubators with 70% or 90% relative humidity (RH).

Study Design: This was a single center retrospective study of extremely preterm infants between 22- and 28-weeks gestational ages nursed in 70% and 90% RH. IWL was calculated using a formula that utilized infants' fluid intake, urine output and body weight changes.

Sequential direct bilirubin values in preterm infants.

Objective: We aim to describe sequential direct bilirubin levels in preterm infants and examine the outcomes of subsequent evaluation of direct hyperbilirubinemia.

Study Design: Retrospective electronic chart analysis of preterm infants admitted and surviving the neonatal intensive care unit (NICU) stay was performed.

Result: A total of 127 preterm infants had 665 bilirubin measurements (333 direct bilirubin; 332 total bilirubin) during their first NICU stay.