Outcomes of utilizing double-incision technique with combination of cortical button and interference screw fixation for distal biceps rupture: A case series.

Background: Distal biceps tendon rupture is an injury that causes a significant reduction in strength and endurance. Combined cortical button and interference screw fixation has been utilized via single-incision technique. There are limited data describing this technique utilizing a double-incision approach.

Gender influence on career trajectory as a shoulder and elbow surgeon.

Background: Women continue to make up a minority of orthopedic surgeons, especially shoulder and elbow surgeons. There exists no study that investigates the effect of gender on one's academic career as a shoulder and elbow orthopedic surgeon, which was the purpose of this cross-sectional study.

Methods: The American Shoulder and Elbow Surgeons website was used to identify surgeons.

Case report: Potential physiological sources of the late response in epidural spinal recordings induced by spinal cord stimulation during intraoperative neuromonitoring.

Objective: This study aims to investigate the sources of later response in epidural spinal recordings (ESRs) obtained from implanted leads during spinal cord stimulation, a topic has not been widely studied in previous research.

Methods: Two patients with lower back and lower extremity pain underwent SCS implantation with intraoperative neuromonitoring (IONM). The timing of extracted peaks in ESRs and intramuscular electromyography (EMG) recordings were analyzed and compared to a Monte Carlo simulation for synchronization analysis.

 (Teleostei, Serranidae), a new species of perchlet from mesophotic coral ecosystems of the Maldives.

Herein, we describe a new species of perchlet found at depths of 100-125 meters in mesophotic coral ecosystems of the Maldives in the Indian Ocean. is unique in both morphology and coloration. The following combination of characters distinguishes it from all known congeners: dorsal fin X, 15; anal-fin rays III, 7; pectoral-fin rays 13 | 13 (13 | 12), all unbranched; principal caudal-fin rays 9 + 8; lateral line complete with 30-32 tubed scales; gill rakers 5 + 12; circumpeduncular scales 11-12; and absence of antrorse or retrorse spines on ventral margin of preopercle.

Incidental discovery of gastrointestinal stromal tumor via PSMA-PET/CT imaging: Insights from a case report.

PSMA-PET/CT has emerged as a superior diagnostic tool for prostate cancer, demonstrating enhanced accuracy over conventional imaging methods. Although sensitive for detecting local and metastatic prostate tumors, it can also identify other non-prostate PSMA positive lesions. Here, we report a rare case of a 67-year-old patient with metastatic prostate adenocarcinoma who was found to have an incidental Gastrointestinal Stromal Tumor (GIST), during restaging with 68Ga-PSMA-11 PET/CT.

Broadband internet access as a social determinant of health in the early COVID-19 pandemic in U.S. counties.

Recent work suggests that internet access was key in delivering life-saving health information about the COVID-19 pandemic. This paper expands on these findings by focusing on the early pandemic in the United States to examine the role of internet access on masking and COVID-19 incidence and mortality. Using county-level data from the American Community Survey, The New York Times, and other sources, weighted OLS regression models with state fixed-effects were used to predict the association of internet access on self-reported masking in July 2020 and COVID-19 incidence and mortality during multiple periods from July-October 2020.

Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised controlled trial.

Background: Vaccine co-administration can increase vaccination coverage. We assessed the safety, reactogenicity, and immunogenicity of concomitant administration of Ad26.COV2.

A variational graph-partitioning approach to modeling protein liquid-liquid phase separation.

Graph neural networks (GNNs) have emerged as powerful tools for representation learning. Their efficacy depends on their having an optimal underlying graph. In many cases, the most relevant information comes from specific subgraphs.

Genomic analysis reveals hidden species diversity in Fabricius (Lepidoptera: Riodinidae).

Genomic analysis of [Fabricius], 1807 (Lepidoptera: Riodinidae Grote, 1895) reveals species richness higher than anticipated. As a result, one subgenus, 22 species, and one subspecies are proposed as new (type species or type localities in parenthesis): Grishin, ( Prittwitz, 1865), () Grishin, (Peru: Rio Pachitea, Monte Alegre), () Grishin, (Guyana: Cuyuni-Mazaruni), () Grishin, (Brazil: Santa Catarina), () Grishin, (Panama: Darién), () Grishin, (Ecuador: Santo Domingo), () Grishin, (Peru: Cuzco), () Grishin, (Panama: Chiriquí), () Grishin, (Mexico: Tamaulipas), () Grishin, (Mexico: Nuevo León), () Grishin, (Argentina: Salta), () Grishin, (Peru: Piura), () Grishin, (Bolivia: La Paz), () Grishin, (Mexico: Sonora), () Grishin, (Peru: Madre de Dios), () Grishin, (Bolivia: La Paz), () Grishin, (Mexico: Chiapas), () Grishin, (Panama: Darién), () Grishin, (Panama: Darién), () Grishin, (Panama: Darién), () Grishin, (Panama: Panamá), () Grishin, (Peru: Cuzco), () Grishin, (Brazil: São Paulo), and () Grishin, (Brazil: Paraná). The following five taxa are (not subspecies): () Schaus, 1928, (not () (Linnaeus, 1767)), () Stichel, 1910, (not () Westwood, 1851), () Stichel, 1929, (not () Godman and Salvin, 1886), () R.

Development of Effective Connectome from Infancy to Adolescence.

Delineating the normative developmental profile of functional connectome is important for both standardized assessment of individual growth and early detection of diseases. However, functional connectome has been mostly studied using functional connectivity (FC), where undirected connectivity strengths are estimated from statistical correlation of resting-state functional MRI (rs-fMRI) signals. To address this limitation, we applied regression dynamic causal modeling (rDCM) to delineate the developmental trajectories of effective connectivity (EC), the directed causal influence among neuronal populations, in whole-brain networks from infancy to adolescence (0-22 years old) based on high-quality rs-fMRI data from Baby Connectome Project (BCP) and Human Connectome Project Development (HCP-D).

All the Way There and Back: Inertial-Based, Phone-in-Pocket Indoor Wayfinding and Backtracking Apps for Blind Travelers.

We describe two iOS apps designed to support blind travelers navigating in indoor building environments. The Wayfinding app provides guidance to a blind user while following a certain route. The Backtracking app records the route taken by the walker towards a certain destination, then provides guidance while re-tracing the same trajectory in the opposite direction.

Acute respiratory distress syndrome (ARDS): from mechanistic insights to therapeutic strategies.

Acute respiratory distress syndrome (ARDS) is a clinical syndrome of acute hypoxic respiratory failure caused by diffuse lung inflammation and edema. ARDS can be precipitated by intrapulmonary factors or extrapulmonary factors, which can lead to severe hypoxemia. Patients suffering from ARDS have high mortality rates, including a 28-day mortality rate of 34.

Molecular Drivers of Aging in Biomolecular Condensates: Desolvation, Rigidification, and Sticker Lifetimes.

Biomolecular condensates are dynamic intracellular entities defined by their sequence- and composition-encoded material properties. During aging, these properties can change dramatically, potentially leading to pathological solidlike states, the mechanisms of which remain poorly understood. Recent experiments reveal that the aging of condensates involves a complex interplay of solvent depletion, strengthening of sticker links, and the formation of rigid structural segments such as beta fibrils.

The utilization of microbial cell-free DNA next-generation sequencing for the detection of human herpesvirus-8 in a quaternary care center.

Background: Human herpesvirus-8 (HHV8) can present with cutaneous or extracutaneous manifestations. While violaceous skin lesions characterize cutaneous Kaposi sarcoma, extracutaneous HHV8 is challenging to diagnose due to nonspecific symptoms.

Objectives: We evaluated the role of microbial cell-free DNA next-generation sequencing (mcfDNA NGS) in diagnosing HHV8-related illness.

Infection prevention in the immunocompromised traveler due to conditions other than transplantation: a review.

This narrative review explores the risks related to infection in immunocompromised travelers due to conditions other than transplantation, and evaluates the evidence behind current prophylactic strategies, including immunizations, antimicrobials, and non-pharmacological interventions, to prevent various infection and how the current evidence applies to this special patient population, from the perspective of a US-based traveler.

Strategies in Management of Pulmonary Embolism With Acute Ischemic Stroke: A Systematic Review.

Pulmonary embolism (PE) and acute ischemic stroke (AIS) are serious conditions with high morbidity and mortality. In the USA, PE causes around 100,000 deaths annually, with higher incidence in males. AIS following PE occurs in 1-10% of cases and is a leading cause of death within 2 - 4 weeks post-stroke.

Serum Vitamin D Level Correlates Significantly With Leptin and Tumor Necrosis Factor-Alpha in Overweight Postmenopausal Women With Hypertension.

Background: Association of serum vitamin D (vitD) with leptin (Lep) and tumor necrosis factor-alpha (TNF-α) is not precisely known in overweight hypertensive (OW-HT) postmenopausal (PMP) women. Hence, the present study was carried out to investigate the body mass index (BMI)-based correlation of serum vitD with Lep and TNF-α in OW-HT PMP women.

Methods: Women subjects in their early PMP (n = 346, age: 51 - 60 years) categorized into three groups had main inclusion criteria of specified range of age, BMI and blood pressure (BP).

Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy.

Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The discovery of exosomes' role in intercellular communication has sparked a great deal of interest in them recently.

EFFECTS OF PREOPERATIVE ANXIETY, DEPRESSION AND PAIN ON QUALITY OF POSTOPERATIVE RECOVERY AND ACUTE POSTOPERATIVE PAIN AFTER RADICAL PROSTATECTOMY: A PROSPECTIVE OBSERVATIONAL STUDY.

Patients with prostate cancer are often in psychological distress and pain preoperatively. The aim of this study was to examine the effects of preoperative anxiety, depression and pain on the quality of postoperative recovery and acute postoperative pain after radical prostatectomy. One hundred and sixty patients scheduled for open or laparoscopic radical prostatectomy were enrolled in a prospective observational study.

From isolation to detection, advancing insights into endothelial matrix-bound vesicles.

Matrix-bound vesicles (MBVs), an integral part of the extracellular matrix (ECM), are emerging as pivotal factors in ECM-driven molecular signaling. This study is the first to report the isolation of MBVs from porcine arterial endothelial cell basement membranes (A-MBVs) and thyroid cartilage (C-MBVs), the latter serving as a negative control due to its minimal vascular characteristics. Using Transmission Electron Microscopy (TEM), Nano-Tracking Analysis (NTA), Electrochemical Impedance Spectroscopy (EIS), and Atomic Force Microscopy (AFM), we orthogonally characterized the isolated MBVs.

Seeing Ourselves in Others: Understanding and Addressing Biases in Medical School Admissions Processes.

Purpose: Medical school admissions is a vital area for advancing diversity, equity, and inclusion (DEI). Integrating bias recognition and management (BRM) within the context of admissions is critical in advancing DEI. However, there is a dearth of empirically informed literature on BRM in the admissions context.

Menopause Legacies: Designing to Record and Share Experiences of Menopause Across Generations.

Menopause is often overlooked or medicalized, consequently devaluing individual experiences and failing to support individuals experiencing this life event. Family dynamics, death, and taboo further mean that individuals often miss out on information that could help them contextualize their experiences. We examine participant experiences with menopause and explore designs of digital and non-digital legacies for sharing menopause experiences across generations.

A Scoping Review of Existing Policy Instruments to Tackle Overweight and Obesity in India: Recommendations for a Social and Behaviour Change Communication Strategy.

Background: The Indian government is committed to addressing various manifestations of malnutrition, including overweight and obesity, inorder to improve individual health and well-being. The scoping review aims to map existing national policy instruments (programmes, schemes, regulations and guidelines) addressing overweight and obesity in India and analysing them for Social and Behaviour Change Communication (SBCC) strategies.

Methods: Systematic identification and selection of policy instruments using 'Arksey and O'Malley' framework was conducted from central government ministry websites, between March and June 2023.

Revisiting the Last Ice Area projections from a high-resolution Global Earth System Model.

The Last Ice Area-located to the north of Greenland and the northern Canadian Arctic Archipelago-is expected to persist as the central Arctic Ocean becomes seasonally ice-free within a few decades. Projections of the Last Ice Area, however, have come from relatively low resolution Global Climate Models that do not resolve sea ice export through the waterways of the Canadian Arctic Archipelago and Nares Strait. Here we revisit Last Ice Area projections using high-resolution numerical simulations from the Community Earth System Model, which resolves these narrow waterways.